| Catalogue number: | PA 40 0571002 |
| Chemical name: | Lys-SMCC-DM1 |
CAS Number: |
1281816-04-3 |
| Category: | aromatics,chiral standards,enzyme inhibitors,pharmaceutical standards,intermediates,Fine Chemicals,Antibody Drug Conjugate |
| Synonyms: | Maytansine, N2′-[3-[[1-[[trans-4-[[[(5S)-5-amino-5-carboxypentyl]amino]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-1-oxopropyl]-N2′-deacetyl-; Lys-Nε-MCC-DM1; N6-((1S,4S)-4-(((S)-3-((3-(((S)-1-(((14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl)oxy)-1-oxopropan-2-yl)(methyl)amino)-3-oxopropyl)thio)-2,5-dioxopyrrolidin-1-yl)methyl)cyclohexane-1-carbonyl)-L-lysine; |
| Molecular form: | C53H75ClN6O15S |
| Appearance: | Solid |
| Mol. Weight: | 1103.72 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a agent-linker conjugates for ADC that can inhibit tubulin polymerization. Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is a HER2-targeting ADC with a tubulin polymerization inhibitor DM1. Lys-SMCC-DM1 can be used in the research of breast cancer |
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