| Catalogue number: | PA 40 0571009 |
| Chemical name: | DBCO-PEG4-Ahx-DM1 |
CAS Number: |
2479378-44-2 |
| Category: | pharmaceutical standards,intermediates,Fine Chemicals,Antibody Drug Conjugate |
| Synonyms: | Maytansine, N2′-deacetyl-N2′-[27-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-2,3-dimethyl-1,8,24,27-tetraoxo-11,14,17,20-tetraoxa-7,23-diazaheptacos-1-yl]-; |
| Molecular form: | C68H89ClN6O17 |
| Appearance: | Solid |
| Mol. Weight: | 1297.94 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | DBCO-PEG4-Ahx-DM1 is a agent-linker conjugate composed of a potent microtubulin inhibitor DM1 and a linker DBCO-PEG4-Ahx to make antibody agent conjugate (ADC). Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. DBCO-PEG4-Ahx-DM1 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups |
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