S-Methyl DM1

In House Impurity

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Catalogue number:	PA 40 0571013
Chemical name:	S-Methyl DM1
CAS Number:	912569-84-7
Category:	aromatics,Chiral standards,enzyme inhibitors,pharmaceutical standards,Intermediates,Fine Chemicals,Antibody Drug Conjugate
Synonyms:	(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-Chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-methyl-N-(3-(methylthio)propanoyl)-L-alaninate; Maytansine, N2′-deacetyl-N2′-[3-(methylthio)-1-oxopropyl]-; N-2′-Deacetyl-N-2′-(3-methylthio-1-oxopropyl)maytansine;
Molecular form:	C₃₆H₅₀ClN₃O₁₀S
Appearance:	NA
Mol. Weight:	752.32
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin with a Kd of 0.93 μM and inhibts microtubule polymerization. S-methyl DM1 potently suppresses microtubule dynamic instability and has anticancer effects