Lotilaner and its Impurities
Lotilaner, sold under the brand name Xdemvy. It is an ectoparasiticide medication. It is an antiparasitic agent used to treat Demodex blepharitis. Reference standards of Lotilaner API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(S)-3-Methyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2-carboxylic Acid
(S)-3-Methyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2-carboxylic Acid
Catalogue No.:PA 12 2131001
CAS :
1918956-01-0
Molecular Formula : C16H9Cl3F3NO3S
Molecular Weight : 458.66


(S)-3-Methyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2-carboxamide
(S)-3-Methyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2-carboxamide
Catalogue No.:PA 12 2131002
CAS :
NA
Molecular Formula : C16H10Cl3F3N2O2S
Molecular Weight : 457.67


(S)-3-(5-Bromo-4-methylthiophen-2-yl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole
(S)-3-(5-Bromo-4-methylthiophen-2-yl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole
Catalogue No.:PA 12 2131003
CAS :
1613733-75-7
Molecular Formula : C15H8BrCl3F3NOS
Molecular Weight : 493.54


(R)-3-(5-Bromo-4-methylthiophen-2-yl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole
(R)-3-(5-Bromo-4-methylthiophen-2-yl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole
Catalogue No.:PA 12 2131004
CAS :
1613733-77-9
Molecular Formula : C15H8BrCl3F3NOS
Molecular Weight : 493.54


Methyl (S)-3-methyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2-carboxylate
Methyl (S)-3-methyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2-carboxylate
Catalogue No.:PA 12 2131005
CAS :
2758907-90-1
Molecular Formula : C17H11Cl3F3NO3S
Molecular Weight : 472.68


Methyl (Z)-3-methyl-5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-2-enoyl)thiophene-2-carboxylate
Methyl (Z)-3-methyl-5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-2-enoyl)thiophene-2-carboxylate
Catalogue No.:PA 12 2131006
CAS :
2758907-89-8
Molecular Formula : C17H10Cl3F3O3S
Molecular Weight : 457.67


Methyl (E)-3-methyl-5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-2-enoyl)thiophene-2-carboxylate
Methyl (E)-3-methyl-5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-2-enoyl)thiophene-2-carboxylate
Catalogue No.:PA 12 2131007
CAS :
2758907-88-7
Molecular Formula : C17H10Cl3F3O3S
Molecular Weight : 457.67


Ethyl 3-methyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2-carboxylate
Ethyl 3-methyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2-carboxylate
Catalogue No.:PA 12 2131008
CAS :
NA
Molecular Formula : C18H13Cl3F3NO3S
Molecular Weight : 486.71