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Pharmaffiliates specialise in structure elucidation using advanced techniques like NMR, Mass Spectrometry (MS), and X-ray crystallography. We accurately identify final products, intermediates, impurities, degradation products, and metabolites to support regulatory and research needs.
Pharmaffiliates, in consultation with its client, establish the most efficient approach for structure elucidation and evaluation by using latest chromatographic and spectroscopic techniques
Pharmaffiliates applies a broad set of analytical techniques — including UV/Vis, HPLC/UPLC, FTIR, ICP/ICP-MS, chiral chromatography, and 1D/2D NMR — to determine the chemical structure of your compounds. This includes identification of final products, intermediates, impurities, degradation products, and metabolites. :contentReference[oaicite:1]{index=1}
Structure elucidation can be performed on active pharmaceutical ingredients (APIs), intermediates, impurities, degradation products, metabolites or any unknown substances (e.g. by-products) in your sample — Pharmaffiliates supports all these. :contentReference[oaicite:2]{index=2}
Depending on the compound and client requirements, Pharmaffiliates may use a combination of chromatography (HPLC/UPLC), spectroscopy (UV, FTIR), mass-based analysis (ICP-MS as needed), chiral chromatography, and high-resolution structural methods such as 1D and 2D NMR, to fully elucidate molecular structure. :contentReference[oaicite:3]{index=3}
You’ll receive a detailed report describing the structure: spectral data (NMR, FTIR, chromatograms), analytical conditions, interpretation, and structural assignment — sufficient for regulatory submission or internal R&D documentation. (Pharmaffiliates’s standard practice under their Structure Elucidation & Evaluation service) :contentReference[oaicite:4]{index=4}
Yes — identifying unknown impurities, degradation products or by-products through structure elucidation is explicitly part of their offering, helping clients to fully characterize all components of their compound mixture. :contentReference[oaicite:5]{index=5}
The required sample amount or purity depends on the complexity of the molecule and the analytical techniques to be used. Pharmaffiliates will define the required sample quantity after reviewing your compound and intended analysis. (Consultation prior to project start is recommended.)
Timeline varies depending on complexity of the molecule, whether impurities/degradants need isolation, and the analytical techniques required. Pharmaffiliates will provide an estimated schedule after initial assessment of your sample and requirements.
Yes — the structural data provided by Pharmaffiliates is suitable for regulatory submissions, impurity profiling, stability studies, and other documentation where unambiguous chemical identity is required. :contentReference[oaicite:6]{index=6}
Yes — structural elucidation may include chiral chromatography and advanced NMR or spectroscopic analysis to determine stereochemistry, if that is a requirement for your compound. :contentReference[oaicite:7]{index=7}
You need to provide the chemical substance (API, intermediate, impurity, etc.), any prior data (if available), approximate sample amount or purity, and intended purpose (e.g. impurity identification, metabolite identification, regulatory filing) — Pharmaffiliates will then propose an analytical plan and quote. :contentReference[oaicite:8]{index=8}
