Abemaciclib and its Impurities

Abemaciclib is used to treat certain types of breast cancer. It belongs to a class of drugs known as kinase inhibitors.Reference standards of Abemaciclib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

Displaying 45 results for Abemaciclib Impurities
Drug Reference Standards & Impurity Synthesis in India
PA 54 15000

Abemaciclib

Abemaciclib

  • Catalogue No.:PA 54 15000

  • CAS :

    1231929-97-7

  • Molecular Formula : C27H32F2N8

  • Molecular Weight : 506.61

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Drug Reference Standards & Impurity Synthesis in India
PA STI 088914

Abemaciclib D8

Abemaciclib D8

  • Catalogue No.:PA STI 088914

  • CAS :

    2088650-53-5

  • Molecular Formula : C27H24D8F2N8

  • Molecular Weight : 514.65

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151000

N-(5-((4-(Ethyl-d5)piperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

N-(5-((4-(Ethyl-d5)piperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

  • Catalogue No.:PA 54 0151000

  • CAS :

    1809251-51-1

  • Molecular Formula : C27H27D5F2N8

  • Molecular Weight : 511.64

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151001

4-Fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

4-Fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

  • Catalogue No.:PA 54 0151001

  • CAS :

    1528469-78-4

  • Molecular Formula : C11H13FN2

  • Molecular Weight : 192.24

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151002

6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)nicotinaldehyde

6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)nicotinaldehyde

  • Catalogue No.:PA 54 0151002

  • CAS :

    1627082-92-1

  • Molecular Formula : C21H18F2N6O

  • Molecular Weight : 408.41

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151003

(6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methanol

(6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methanol

  • Catalogue No.:PA 54 0151003

  • CAS :

    1648707-16-7

  • Molecular Formula : C21H20F2N6O

  • Molecular Weight : 410.43

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151004

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-2-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-4-amine

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-2-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-4-amine

  • Catalogue No.:PA 54 0151004

  • CAS :

    NA

  • Molecular Formula : C27H32F2N8

  • Molecular Weight : 506.61

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151005

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)pyrimidin-2-amine

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)pyrimidin-2-amine

  • Catalogue No.:PA 54 0151005

  • CAS :

    NA

  • Molecular Formula : C42H44F4N12

  • Molecular Weight : 792.89

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151006

N,N'-((Piperazine-1,4-diylbis(methylene))bis(pyridine-5,2-diyl))bis(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine)

N,N'-((Piperazine-1,4-diylbis(methylene))bis(pyridine-5,2-diyl))bis(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine)

  • Catalogue No.:PA 54 0151006

  • CAS :

    NA

  • Molecular Formula : C46H46F4N14

  • Molecular Weight : 870.97

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151007

1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridin-3-yl)methyl)piperazine 1,4-dioxide

1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridin-3-yl)methyl)piperazine 1,4-dioxide

  • Catalogue No.:PA 54 0151007

  • CAS :

    NA

  • Molecular Formula : C28H33F2N7O2

  • Molecular Weight : 537.62

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151008

4-Ethyl-1-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridin-3-yl)methyl)piperazine 1-oxide

4-Ethyl-1-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridin-3-yl)methyl)piperazine 1-oxide

  • Catalogue No.:PA 54 0151008

  • CAS :

    NA

  • Molecular Formula : C28H33F2N7O

  • Molecular Weight : 521.62

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151009

1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridin-3-yl)methyl)piperazine 1-oxide

1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridin-3-yl)methyl)piperazine 1-oxide

  • Catalogue No.:PA 54 0151009

  • CAS :

    NA

  • Molecular Formula : C28H33F2N7O

  • Molecular Weight : 521.62

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151010

N-(4-Bromo-2,6-difluorophenyl)-N'-isopropylacetimidamide

N-(4-Bromo-2,6-difluorophenyl)-N'-isopropylacetimidamide

  • Catalogue No.:PA 54 0151010

  • CAS :

    1231930-29-2

  • Molecular Formula : C11H13BrF2N2

  • Molecular Weight : 291.14

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151011

6-(2-Chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

6-(2-Chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

  • Catalogue No.:PA 54 0151011

  • CAS :

    1231930-42-9

  • Molecular Formula : C15H13ClF2N4

  • Molecular Weight : 322.74

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151012

(6-Aminopyridin-3-yl)(4-ethylpiperazin-1-yl)methanone

(6-Aminopyridin-3-yl)(4-ethylpiperazin-1-yl)methanone

  • Catalogue No.:PA 54 0151012

  • CAS :

    1275904-70-5

  • Molecular Formula : C12H18N4O

  • Molecular Weight : 234.3

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151013

6-Chloro-5-fluoropyrimidin-2(1H)-one

6-Chloro-5-fluoropyrimidin-2(1H)-one

  • Catalogue No.:PA 54 0151013

  • CAS :

    22462-34-6

  • Molecular Formula : C4H2ClFN2O

  • Molecular Weight : 148.52

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151014

6-Bromo-4-fluoro-2-methyl-1-propyl-1H-benzo[d]imidazole

6-Bromo-4-fluoro-2-methyl-1-propyl-1H-benzo[d]imidazole

  • Catalogue No.:PA 54 0151014

  • CAS :

    1844847-62-6

  • Molecular Formula : C11H12BrFN2

  • Molecular Weight : 271.13

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151015

6-Bromo-1-ethyl-4-fluoro-2-methyl-1H-benzo[d]imidazole

6-Bromo-1-ethyl-4-fluoro-2-methyl-1H-benzo[d]imidazole

  • Catalogue No.:PA 54 0151015

  • CAS :

    2189739-28-2

  • Molecular Formula : C10H10BrFN2

  • Molecular Weight : 257.11

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151016

Abemaciclib Metabolites M2

Abemaciclib Metabolites M2

  • Catalogue No.:PA 54 0151016

  • CAS :

    1231930-57-6

  • Molecular Formula : C25H28F2N8

  • Molecular Weight : 478.55

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151017

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)nitrous amide

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)nitrous amide

  • Catalogue No.:PA 54 0151017

  • CAS :

    NA

  • Molecular Formula : C27H31F2N9O

  • Molecular Weight : 535.6

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151018

5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine

5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine

  • Catalogue No.:PA 54 0151018

  • CAS :

    1180132-17-5

  • Molecular Formula : C12H20N4

  • Molecular Weight : 220.32

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151019

Abemaciclib Metabolite M18

Abemaciclib Metabolite M18

  • Catalogue No.:PA 54 0151019

  • CAS :

    2704316-81-2

  • Molecular Formula : C25H28F2N8O

  • Molecular Weight : 494.55

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151020

Abemaciclib Metabolite M20

Abemaciclib Metabolite M20

  • Catalogue No.:PA 54 0151020

  • CAS :

    2138499-06-4

  • Molecular Formula : C27H32F2N8O

  • Molecular Weight : 522.6

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151021

5-((4-Nitrosopiperazin-1-yl)methyl)pyridin-2-amine

5-((4-Nitrosopiperazin-1-yl)methyl)pyridin-2-amine

  • Catalogue No.:PA 54 0151021

  • CAS :

    NA

  • Molecular Formula : C10H15N5O

  • Molecular Weight : 221.26

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151022

1-((6-Bromopyridin-3-yl)methyl)-4-nitrosopiperazine

1-((6-Bromopyridin-3-yl)methyl)-4-nitrosopiperazine

  • Catalogue No.:PA 54 0151022

  • CAS :

    NA

  • Molecular Formula : C10H13BrN4O

  • Molecular Weight : 285.15

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151023

5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-((4-nitrosopiperazin-1-yl)methyl)pyridin-2-yl)pyrimidin-2-amine

5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-((4-nitrosopiperazin-1-yl)methyl)pyridin-2-yl)pyrimidin-2-amine

  • Catalogue No.:PA 54 0151023

  • CAS :

    NA

  • Molecular Formula : C25H27F2N9O

  • Molecular Weight : 507.55

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151024

N-(4-Bromo-2,6-difluorophenyl)acetamide

N-(4-Bromo-2,6-difluorophenyl)acetamide

  • Catalogue No.:PA 54 0151024

  • CAS :

    658072-14-1

  • Molecular Formula : C8H6BrF2NO

  • Molecular Weight : 250.04

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151026

6-(2-Chloro-5-fluoropyrimidin-4-yl)-1-isopropyl-2-methyl-1H-benzo[d]imidazole

6-(2-Chloro-5-fluoropyrimidin-4-yl)-1-isopropyl-2-methyl-1H-benzo[d]imidazole

  • Catalogue No.:PA 54 0151026

  • CAS :

    1873303-32-2

  • Molecular Formula : C15H14ClFN4

  • Molecular Weight : 304.75

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151025

6-(2-Chloropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

6-(2-Chloropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

  • Catalogue No.:PA 54 0151025

  • CAS :

    1231930-47-4

  • Molecular Formula : C15H14ClFN4

  • Molecular Weight : 304.75

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151027

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

  • Catalogue No.:PA 54 0151027

  • CAS :

    NA

  • Molecular Formula : C27H33FN8

  • Molecular Weight : 488.62

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151028

Abemaciclib Desfluoro Pyrimidine Imidazole Impurity

Abemaciclib Desfluoro Pyrimidine Imidazole Impurity

  • Catalogue No.:PA 54 0151028

  • CAS :

    NA

  • Molecular Formula : C27H33FN8

  • Molecular Weight : 488.62

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151029

4-Ethyl-1-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine 1-oxide

4-Ethyl-1-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine 1-oxide

  • Catalogue No.:PA 54 0151029

  • CAS :

    NA

  • Molecular Formula : C27H32F2N8O

  • Molecular Weight : 522.6

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151030

1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine 1,4-dioxide

1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine 1,4-dioxide

  • Catalogue No.:PA 54 0151030

  • CAS :

    NA

  • Molecular Formula : C27H32F2N8O2

  • Molecular Weight : 538.6

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151031

(4-Fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)boronic Acid

(4-Fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)boronic Acid

  • Catalogue No.:PA 54 0151031

  • CAS :

    2346512-66-9

  • Molecular Formula : C11H14BFN2O2

  • Molecular Weight : 236.05

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151032

2,5-Dichloropyrimidin-4-amine

2,5-Dichloropyrimidin-4-amine

  • Catalogue No.:PA 54 0151032

  • CAS :

    89180-51-8

  • Molecular Formula : C4H3Cl2N3

  • Molecular Weight : 163.99

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151033

4-Fluoro-6-(5-fluoropyrimidin-4-yl)-1-isopropyl-2-methyl-1H-benzo[d]imidazole

4-Fluoro-6-(5-fluoropyrimidin-4-yl)-1-isopropyl-2-methyl-1H-benzo[d]imidazole

  • Catalogue No.:PA 54 0151033

  • CAS :

    NA

  • Molecular Formula : C15H14F2N4

  • Molecular Weight : 288.3

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151034

1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine 1-oxide

1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine 1-oxide

  • Catalogue No.:PA 54 0151034

  • CAS :

    NA

  • Molecular Formula : C27H32F2N8O

  • Molecular Weight : 522.6

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151035

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-2-methyl-1-nitroso-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-2-methyl-1-nitroso-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

  • Catalogue No.:PA 54 0151035

  • CAS :

    NA

  • Molecular Formula : C24H25F2N9O

  • Molecular Weight : 493.52

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151036

6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)nicotinic Acid

6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)nicotinic Acid

  • Catalogue No.:PA 54 0151036

  • CAS :

    NA

  • Molecular Formula : C21H18F2N6O2

  • Molecular Weight : 424.41

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PA 54 0151037

6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-ol

6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-ol

  • Catalogue No.:PA 54 0151037

  • CAS :

    NA

  • Molecular Formula : C20H18F2N6O

  • Molecular Weight : 396.4

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PA 54 0151038

1-((6-Bromopyridin-3-yl)methyl)-4-ethylpiperazine

1-((6-Bromopyridin-3-yl)methyl)-4-ethylpiperazine

  • Catalogue No.:PA 54 0151038

  • CAS :

    1231930-25-8

  • Molecular Formula : C12H18BrN3

  • Molecular Weight : 284.2

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Drug Reference Standards & Impurity Synthesis in India
PA 54 0151039

5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

  • Catalogue No.:PA 54 0151039

  • CAS :

    2055637-56-2

  • Molecular Formula : C15H15F2N5

  • Molecular Weight : 303.32

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PA 54 0151040

1,4-Bis((6-chloropyridin-3-yl)methyl)piperazine

1,4-Bis((6-chloropyridin-3-yl)methyl)piperazine

  • Catalogue No.:PA 54 0151040

  • CAS :

    230617-68-2

  • Molecular Formula : C16H18Cl2N4

  • Molecular Weight : 337.25

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PA 54 0151041

7,7'-Difluoro-3,3'-diisopropyl-2,2'-dimethyl-3H,3'H-5,5'-bibenzo[d]imidazole

7,7'-Difluoro-3,3'-diisopropyl-2,2'-dimethyl-3H,3'H-5,5'-bibenzo[d]imidazole

  • Catalogue No.:PA 54 0151041

  • CAS :

    3062616-90-1

  • Molecular Formula : C22H24F2N4

  • Molecular Weight : 382.46

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PA 54 0151042

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-N-(4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)nitrous amide

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-N-(4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)nitrous amide

  • Catalogue No.:PA 54 0151042

  • CAS :

    NA

  • Molecular Formula : C27H32FN9O

  • Molecular Weight : 517.61

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