Abemaciclib and its Impurities
Abemaciclib is used to treat certain types of breast cancer. It belongs to a class of drugs known as kinase inhibitors.Reference standards of Abemaciclib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
N-(5-((4-(Ethyl-d5)piperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine
N-(5-((4-(Ethyl-d5)piperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine
Catalogue No.:PA 54 0151000
CAS :
1809251-51-1
Molecular Formula : C27H27D5F2N8
Molecular Weight : 511.64
6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)nicotinaldehyde
6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)nicotinaldehyde
Catalogue No.:PA 54 0151002
CAS :
1627082-92-1
Molecular Formula : C21H18F2N6O
Molecular Weight : 408.41
(6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methanol
(6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methanol
Catalogue No.:PA 54 0151003
CAS :
1648707-16-7
Molecular Formula : C21H20F2N6O
Molecular Weight : 410.43
N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-2-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-4-amine
N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-2-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-4-amine
Catalogue No.:PA 54 0151004
CAS :
NA
Molecular Formula : C27H32F2N8
Molecular Weight : 506.61
N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)pyrimidin-2-amine
N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)pyrimidin-2-amine
Catalogue No.:PA 54 0151005
CAS :
NA
Molecular Formula : C42H44F4N12
Molecular Weight : 792.89
N,N'-((Piperazine-1,4-diylbis(methylene))bis(pyridine-5,2-diyl))bis(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine)
N,N'-((Piperazine-1,4-diylbis(methylene))bis(pyridine-5,2-diyl))bis(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine)
Catalogue No.:PA 54 0151006
CAS :
NA
Molecular Formula : C46H46F4N14
Molecular Weight : 870.97
1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridin-3-yl)methyl)piperazine 1,4-dioxide
1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridin-3-yl)methyl)piperazine 1,4-dioxide
Catalogue No.:PA 54 0151007
CAS :
NA
Molecular Formula : C28H33F2N7O2
Molecular Weight : 537.62
4-Ethyl-1-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridin-3-yl)methyl)piperazine 1-oxide
4-Ethyl-1-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridin-3-yl)methyl)piperazine 1-oxide
Catalogue No.:PA 54 0151008
CAS :
NA
Molecular Formula : C28H33F2N7O
Molecular Weight : 521.62
1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridin-3-yl)methyl)piperazine 1-oxide
1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridin-3-yl)methyl)piperazine 1-oxide
Catalogue No.:PA 54 0151009
CAS :
NA
Molecular Formula : C28H33F2N7O
Molecular Weight : 521.62
N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)nitrous amide
N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)nitrous amide
Catalogue No.:PA 54 0151017
CAS :
NA
Molecular Formula : C27H31F2N9O
Molecular Weight : 535.6
5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-((4-nitrosopiperazin-1-yl)methyl)pyridin-2-yl)pyrimidin-2-amine
5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-((4-nitrosopiperazin-1-yl)methyl)pyridin-2-yl)pyrimidin-2-amine
Catalogue No.:PA 54 0151023
CAS :
NA
Molecular Formula : C25H27F2N9O
Molecular Weight : 507.55
N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine
N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine
Catalogue No.:PA 54 0151027
CAS :
NA
Molecular Formula : C27H33FN8
Molecular Weight : 488.62
4-Ethyl-1-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine 1-oxide
4-Ethyl-1-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine 1-oxide
Catalogue No.:PA 54 0151029
CAS :
NA
Molecular Formula : C27H32F2N8O
Molecular Weight : 522.6
1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine 1,4-dioxide
1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine 1,4-dioxide
Catalogue No.:PA 54 0151030
CAS :
NA
Molecular Formula : C27H32F2N8O2
Molecular Weight : 538.6
1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine 1-oxide
1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine 1-oxide
Catalogue No.:PA 54 0151034
CAS :
NA
Molecular Formula : C27H32F2N8O
Molecular Weight : 522.6
N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-2-methyl-1-nitroso-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine
N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-2-methyl-1-nitroso-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine
Catalogue No.:PA 54 0151035
CAS :
NA
Molecular Formula : C24H25F2N9O
Molecular Weight : 493.52
6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)nicotinic Acid
6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)nicotinic Acid
Catalogue No.:PA 54 0151036
CAS :
NA
Molecular Formula : C21H18F2N6O2
Molecular Weight : 424.41
6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-ol
6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-ol
Catalogue No.:PA 54 0151037
CAS :
NA
Molecular Formula : C20H18F2N6O
Molecular Weight : 396.4
N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-N-(4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)nitrous amide
N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-N-(4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)nitrous amide
Catalogue No.:PA 54 0151042
CAS :
NA
Molecular Formula : C27H32FN9O
Molecular Weight : 517.61
6,6'-(5,5'-Difluoro-[2,2'-bipyrimidine]-4,4'-diyl)bis(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole)
6,6'-(5,5'-Difluoro-[2,2'-bipyrimidine]-4,4'-diyl)bis(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole)
Catalogue No.:PA 54 0151043
CAS :
NA
Molecular Formula : C30H26F4N8
Molecular Weight : 574.59
N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-N-(5-fluoro-4-(4-fluoro-1-nitroso-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)nitrous amide
N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-N-(5-fluoro-4-(4-fluoro-1-nitroso-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)nitrous amide
Catalogue No.:PA 54 0151044
CAS :
NA
Molecular Formula : C23H22F2N10O2
Molecular Weight : 508.49

