Abemaciclib and its Impurities

Abemaciclib is used to treat certain types of breast cancer. It belongs to a class of drugs known as kinase inhibitors.Reference standards of Abemaciclib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

Displaying 38 results for Abemaciclib Impurities
PA 54 15000

Abemaciclib

Abemaciclib

  • Catalogue No.:PA 54 15000

  • CAS :

    1231929-97-7

  • Molecular Formula : C27H32F2N8

  • Molecular Weight : 506.61

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PA STI 088914

Abemaciclib D8

Abemaciclib D8

  • Catalogue No.:PA STI 088914

  • CAS :

    2088650-53-5

  • Molecular Formula : C27H24D8F2N8

  • Molecular Weight : 514.65

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PA 54 0151000

N-(5-((4-(Ethyl-d5)piperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

N-(5-((4-(Ethyl-d5)piperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

  • Catalogue No.:PA 54 0151000

  • CAS :

    1809251-51-1

  • Molecular Formula : C27H27D5F2N8

  • Molecular Weight : 511.64

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PA 54 0151001

4-Fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

4-Fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

  • Catalogue No.:PA 54 0151001

  • CAS :

    1528469-78-4

  • Molecular Formula : C11H13FN2

  • Molecular Weight : 192.24

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PA 54 0151002

6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)nicotinaldehyde

6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)nicotinaldehyde

  • Catalogue No.:PA 54 0151002

  • CAS :

    1627082-92-1

  • Molecular Formula : C21H18F2N6O

  • Molecular Weight : 408.41

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PA 54 0151003

(6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methanol

(6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methanol

  • Catalogue No.:PA 54 0151003

  • CAS :

    1648707-16-7

  • Molecular Formula : C21H20F2N6O

  • Molecular Weight : 410.43

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PA 54 0151004

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-2-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-4-amine

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-2-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-4-amine

  • Catalogue No.:PA 54 0151004

  • CAS :

    NA

  • Molecular Formula : C27H32F2N8

  • Molecular Weight : 506.61

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PA 54 0151005

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)pyrimidin-2-amine

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)pyrimidin-2-amine

  • Catalogue No.:PA 54 0151005

  • CAS :

    NA

  • Molecular Formula : C42H44F4N12

  • Molecular Weight : 792.89

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PA 54 0151006

N,N'-((Piperazine-1,4-diylbis(methylene))bis(pyridine-5,2-diyl))bis(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine)

N,N'-((Piperazine-1,4-diylbis(methylene))bis(pyridine-5,2-diyl))bis(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine)

  • Catalogue No.:PA 54 0151006

  • CAS :

    NA

  • Molecular Formula : C46H46F4N14

  • Molecular Weight : 870.97

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PA 54 0151007

1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridin-3-yl)methyl)piperazine 1,4-dioxide

1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridin-3-yl)methyl)piperazine 1,4-dioxide

  • Catalogue No.:PA 54 0151007

  • CAS :

    NA

  • Molecular Formula : C28H33F2N7O2

  • Molecular Weight : 537.62

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PA 54 0151008

4-Ethyl-1-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridin-3-yl)methyl)piperazine 1-oxide

4-Ethyl-1-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridin-3-yl)methyl)piperazine 1-oxide

  • Catalogue No.:PA 54 0151008

  • CAS :

    NA

  • Molecular Formula : C28H33F2N7O

  • Molecular Weight : 521.62

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PA 54 0151009

1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridin-3-yl)methyl)piperazine 1-oxide

1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridin-3-yl)methyl)piperazine 1-oxide

  • Catalogue No.:PA 54 0151009

  • CAS :

    NA

  • Molecular Formula : C28H33F2N7O

  • Molecular Weight : 521.62

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PA 54 0151010

N-(4-Bromo-2,6-difluorophenyl)-N'-isopropylacetimidamide

N-(4-Bromo-2,6-difluorophenyl)-N'-isopropylacetimidamide

  • Catalogue No.:PA 54 0151010

  • CAS :

    1231930-29-2

  • Molecular Formula : C11H13BrF2N2

  • Molecular Weight : 291.14

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PA 54 0151011

6-(2-Chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

6-(2-Chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

  • Catalogue No.:PA 54 0151011

  • CAS :

    1231930-42-9

  • Molecular Formula : C15H13ClF2N4

  • Molecular Weight : 322.74

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PA 54 0151012

(6-Aminopyridin-3-yl)(4-ethylpiperazin-1-yl)methanone

(6-Aminopyridin-3-yl)(4-ethylpiperazin-1-yl)methanone

  • Catalogue No.:PA 54 0151012

  • CAS :

    1275904-70-5

  • Molecular Formula : C12H18N4O

  • Molecular Weight : 234.3

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PA 54 0151013

6-Chloro-5-fluoropyrimidin-2(1H)-one

6-Chloro-5-fluoropyrimidin-2(1H)-one

  • Catalogue No.:PA 54 0151013

  • CAS :

    22462-34-6

  • Molecular Formula : C4H2ClFN2O

  • Molecular Weight : 148.52

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PA 54 0151014

6-Bromo-4-fluoro-2-methyl-1-propyl-1H-benzo[d]imidazole

6-Bromo-4-fluoro-2-methyl-1-propyl-1H-benzo[d]imidazole

  • Catalogue No.:PA 54 0151014

  • CAS :

    1844847-62-6

  • Molecular Formula : C11H12BrFN2

  • Molecular Weight : 271.13

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PA 54 0151015

6-Bromo-1-ethyl-4-fluoro-2-methyl-1H-benzo[d]imidazole

6-Bromo-1-ethyl-4-fluoro-2-methyl-1H-benzo[d]imidazole

  • Catalogue No.:PA 54 0151015

  • CAS :

    2189739-28-2

  • Molecular Formula : C10H10BrFN2

  • Molecular Weight : 257.11

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PA 54 0151016

Abemaciclib Metabolites M2

Abemaciclib Metabolites M2

  • Catalogue No.:PA 54 0151016

  • CAS :

    1231930-57-6

  • Molecular Formula : C25H28F2N8

  • Molecular Weight : 478.55

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PA 54 0151017

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)nitrous amide

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)nitrous amide

  • Catalogue No.:PA 54 0151017

  • CAS :

    NA

  • Molecular Formula : C27H31F2N9O

  • Molecular Weight : 535.6

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PA 54 0151018

5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine

5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine

  • Catalogue No.:PA 54 0151018

  • CAS :

    1180132-17-5

  • Molecular Formula : C12H20N4

  • Molecular Weight : 220.32

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PA 54 0151019

Abemaciclib Metabolite M18

Abemaciclib Metabolite M18

  • Catalogue No.:PA 54 0151019

  • CAS :

    2704316-81-2

  • Molecular Formula : C25H28F2N8O

  • Molecular Weight : 494.55

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PA 54 0151020

Abemaciclib Metabolite M20

Abemaciclib Metabolite M20

  • Catalogue No.:PA 54 0151020

  • CAS :

    2138499-06-4

  • Molecular Formula : C27H32F2N8O

  • Molecular Weight : 522.6

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PA 54 0151021

5-((4-Nitrosopiperazin-1-yl)methyl)pyridin-2-amine

5-((4-Nitrosopiperazin-1-yl)methyl)pyridin-2-amine

  • Catalogue No.:PA 54 0151021

  • CAS :

    NA

  • Molecular Formula : C10H15N5O

  • Molecular Weight : 221.26

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PA 54 0151022

1-((6-Bromopyridin-3-yl)methyl)-4-nitrosopiperazine

1-((6-Bromopyridin-3-yl)methyl)-4-nitrosopiperazine

  • Catalogue No.:PA 54 0151022

  • CAS :

    NA

  • Molecular Formula : C10H13BrN4O

  • Molecular Weight : 285.15

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PA 54 0151023

5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-((4-nitrosopiperazin-1-yl)methyl)pyridin-2-yl)pyrimidin-2-amine

5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-((4-nitrosopiperazin-1-yl)methyl)pyridin-2-yl)pyrimidin-2-amine

  • Catalogue No.:PA 54 0151023

  • CAS :

    NA

  • Molecular Formula : C25H27F2N9O

  • Molecular Weight : 507.55

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PA 54 0151024

N-(4-Bromo-2,6-difluorophenyl)acetamide

N-(4-Bromo-2,6-difluorophenyl)acetamide

  • Catalogue No.:PA 54 0151024

  • CAS :

    658072-14-1

  • Molecular Formula : C8H6BrF2NO

  • Molecular Weight : 250.04

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PA 54 0151026

6-(2-Chloro-5-fluoropyrimidin-4-yl)-1-isopropyl-2-methyl-1H-benzo[d]imidazole

6-(2-Chloro-5-fluoropyrimidin-4-yl)-1-isopropyl-2-methyl-1H-benzo[d]imidazole

  • Catalogue No.:PA 54 0151026

  • CAS :

    1873303-32-2

  • Molecular Formula : C15H14ClFN4

  • Molecular Weight : 304.75

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PA 54 0151025

6-(2-Chloropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

6-(2-Chloropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

  • Catalogue No.:PA 54 0151025

  • CAS :

    1231930-47-4

  • Molecular Formula : C15H14ClFN4

  • Molecular Weight : 304.75

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PA 54 0151027

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

  • Catalogue No.:PA 54 0151027

  • CAS :

    NA

  • Molecular Formula : C27H33FN8

  • Molecular Weight : 488.62

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PA 54 0151028

Abemaciclib Desfluoro Pyrimidine Imidazole Impurity

Abemaciclib Desfluoro Pyrimidine Imidazole Impurity

  • Catalogue No.:PA 54 0151028

  • CAS :

    NA

  • Molecular Formula : C27H33FN8

  • Molecular Weight : 488.62

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PA 54 0151029

4-Ethyl-1-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine 1-oxide

4-Ethyl-1-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine 1-oxide

  • Catalogue No.:PA 54 0151029

  • CAS :

    NA

  • Molecular Formula : C27H32F2N8O

  • Molecular Weight : 522.6

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PA 54 0151030

1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine 1,4-dioxide

1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine 1,4-dioxide

  • Catalogue No.:PA 54 0151030

  • CAS :

    NA

  • Molecular Formula : C27H32F2N8O2

  • Molecular Weight : 538.6

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PA 54 0151031

(4-Fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)boronic Acid

(4-Fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)boronic Acid

  • Catalogue No.:PA 54 0151031

  • CAS :

    2346512-66-9

  • Molecular Formula : C11H14BFN2O2

  • Molecular Weight : 236.05

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PA 54 0151032

2,5-Dichloropyrimidin-4-amine

2,5-Dichloropyrimidin-4-amine

  • Catalogue No.:PA 54 0151032

  • CAS :

    89180-51-8

  • Molecular Formula : C4H3Cl2N3

  • Molecular Weight : 163.99

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PA 54 0151033

4-Fluoro-6-(5-fluoropyrimidin-4-yl)-1-isopropyl-2-methyl-1H-benzo[d]imidazole

4-Fluoro-6-(5-fluoropyrimidin-4-yl)-1-isopropyl-2-methyl-1H-benzo[d]imidazole

  • Catalogue No.:PA 54 0151033

  • CAS :

    NA

  • Molecular Formula : C15H14F2N4

  • Molecular Weight : 288.3

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PA 54 0151034

1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine 1-oxide

1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazine 1-oxide

  • Catalogue No.:PA 54 0151034

  • CAS :

    NA

  • Molecular Formula : C27H32F2N8O

  • Molecular Weight : 522.6

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PA 54 0151035

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-2-methyl-1-nitroso-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-2-methyl-1-nitroso-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

  • Catalogue No.:PA 54 0151035

  • CAS :

    NA

  • Molecular Formula : C24H25F2N9O

  • Molecular Weight : 493.52

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