Acalabrutinib and its Impurities

Acalabrutinib is used to treat certain types of cancer. It is a second generation Bruton's tyrosine kinase inhibitor.Reference standards of Acalabrutinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

Displaying 39 results for Acalabrutinib Impurities
PA 54 50000

Acalabrutinib

Acalabrutinib

  • Catalogue No.:PA 54 50000

  • CAS :

    1420477-60-6

  • Molecular Formula : C26H23N7O2

  • Molecular Weight : 465.52

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PA 54 50510

4-(8-Amino-3-(4-(but-2-ynamido)butanoyl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

4-(8-Amino-3-(4-(but-2-ynamido)butanoyl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

  • Catalogue No.:PA 54 50510

  • CAS :

    2230757-47-6

  • Molecular Formula : C26H23N7O3

  • Molecular Weight : 481.52

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PA 54 0501000

Benzyl (S)-2-(8-amino-6-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

Benzyl (S)-2-(8-amino-6-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

  • Catalogue No.:PA 54 0501000

  • CAS :

    NA

  • Molecular Formula : C18H18BrN5O2

  • Molecular Weight : 416.28

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PA 54 0501001

Benzyl (S)-2-(8-amino-5-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

Benzyl (S)-2-(8-amino-5-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

  • Catalogue No.:PA 54 0501001

  • CAS :

    NA

  • Molecular Formula : C18H18BrN5O2

  • Molecular Weight : 416.28

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PA 54 0501002

 (2R)-2-Amino-3-[(E)-3-[(2S)-2-[8-amino-1-[4-(2-pyridylcarbamoyl)phenyl]imidazo [1,5-a]pyrazin-3-yl]pyrrolidin-1-yl]-1-methyl-3-oxo-prop-1-enyl]sulfanyl-propanoic acid

(2R)-2-Amino-3-[(E)-3-[(2S)-2-[8-amino-1-[4-(2-pyridylcarbamoyl)phenyl]imidazo [1,5-a]pyrazin-3-yl]pyrrolidin-1-yl]-1-methyl-3-oxo-prop-1-enyl]sulfanyl-propanoic acid

  • Catalogue No.:PA 54 0501002

  • CAS :

    NA

  • Molecular Formula : C29H30N8O4S

  • Molecular Weight : 586.67

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PA 54 0501003

4-[8-Amino-3-[(2S)-1-(3-oxobutanoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-(2-pyridyl)benzamide

4-[8-Amino-3-[(2S)-1-(3-oxobutanoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-(2-pyridyl)benzamide

  • Catalogue No.:PA 54 0501003

  • CAS :

    NA

  • Molecular Formula : C26H25N7O3

  • Molecular Weight : 483.53

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PA 54 0501004

N-(Pyridin-2-yl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

N-(Pyridin-2-yl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

  • Catalogue No.:PA 54 0501004

  • CAS :

    2180911-32-2

  • Molecular Formula : C18H21BN2O3

  • Molecular Weight : 324.19

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PA 54 0501005

N-2-Pyridinyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

N-2-Pyridinyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

  • Catalogue No.:PA 54 0501005

  • CAS :

    2180911-29-7

  • Molecular Formula : C18H21BN2O3

  • Molecular Weight : 324.19

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PA 54 0501006

(4-[8-Amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]benzoic acid)

(4-[8-Amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]benzoic acid)

  • Catalogue No.:PA 54 0501006

  • CAS :

    NA

  • Molecular Formula : C21H19N5O3

  • Molecular Weight : 389.42

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PA STI 088915

Acalabrutinib D4

Acalabrutinib D4

  • Catalogue No.:PA STI 088915

  • CAS :

    2699608-18-7

  • Molecular Formula : C26H19D4N7O2

  • Molecular Weight : 469.54

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PA 54 0501007

(S)-4-(9-(1-(But-2-ynoyl)pyrrolidin-2-yl)-4-methyl-2-oxo-2H-imidazo[5',1':3,4]pyrazino[1,2-a]pyrimidin-11-yl)-N-(pyridin-2-yl)benzamide

(S)-4-(9-(1-(But-2-ynoyl)pyrrolidin-2-yl)-4-methyl-2-oxo-2H-imidazo[5',1':3,4]pyrazino[1,2-a]pyrimidin-11-yl)-N-(pyridin-2-yl)benzamide

  • Catalogue No.:PA 54 0501007

  • CAS :

    2490433-97-9

  • Molecular Formula : C30H25N7O3

  • Molecular Weight : 531.58

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PA 54 0501008

4-(8-((4-((S)-2-(8-Amino-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazin-3-yl)pyrrolidin-1-yl)-4-oxobut-2-en-2-yl)amino)-3-((S)-1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

4-(8-((4-((S)-2-(8-Amino-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazin-3-yl)pyrrolidin-1-yl)-4-oxobut-2-en-2-yl)amino)-3-((S)-1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

  • Catalogue No.:PA 54 0501008

  • CAS :

    NA

  • Molecular Formula : C52H46N14O4

  • Molecular Weight : 931.03

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PA 54 0501009

Acalabrutinib 8-Hydroxy Impurity

Acalabrutinib 8-Hydroxy Impurity

  • Catalogue No.:PA 54 0501009

  • CAS :

    NA

  • Molecular Formula : C26H22N6O3

  • Molecular Weight : 466.5

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PA 54 0501010

Propiolic Acid

Propiolic Acid

  • Catalogue No.:PA 54 0501010

  • CAS :

    471-25-0

  • Molecular Formula : C3H2O2

  • Molecular Weight : 70.05

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PA 54 0501011

Acalabrutinib M45 Metabolite

Acalabrutinib M45 Metabolite

  • Catalogue No.:PA 54 0501011

  • CAS :

    NA

  • Molecular Formula : C26H27N7O3

  • Molecular Weight : 485.55

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PA 54 0501012

Acalabrutinib R-Isomer

Acalabrutinib R-Isomer

  • Catalogue No.:PA 54 0501012

  • CAS :

    1952316-43-6

  • Molecular Formula : C26H23N7O2

  • Molecular Weight : 465.52

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PA 54 0501013

(S)-4-(9-(1-(But-2-ynoyl)pyrrolidin-2-yl)-2-methyl-4-oxo-4H-imidazo[5',1':3,4]pyrazino[1,2-a]pyrimidin-11-yl)-N-(pyridin-2-yl)benzamide

(S)-4-(9-(1-(But-2-ynoyl)pyrrolidin-2-yl)-2-methyl-4-oxo-4H-imidazo[5',1':3,4]pyrazino[1,2-a]pyrimidin-11-yl)-N-(pyridin-2-yl)benzamide

  • Catalogue No.:PA 54 0501013

  • CAS :

    2412166-56-2

  • Molecular Formula : C30H25N7O3

  • Molecular Weight : 531.58

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PA 54 0501014

Acalabrutinib Acetyl Impurity

Acalabrutinib Acetyl Impurity

  • Catalogue No.:PA 54 0501014

  • CAS :

    NA

  • Molecular Formula : C24H23N7O2

  • Molecular Weight : 441.5

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PA 54 0501015

Benzyl 2-(1-bromo-8-hydroxyimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

Benzyl 2-(1-bromo-8-hydroxyimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

  • Catalogue No.:PA 54 0501015

  • CAS :

    NA

  • Molecular Formula : C18H17BrN4O3

  • Molecular Weight : 417.26

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PA 54 0501016

Benzyl 2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

Benzyl 2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

  • Catalogue No.:PA 54 0501016

  • CAS :

    2251014-90-9

  • Molecular Formula : C18H18BrN5O2

  • Molecular Weight : 416.28

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PA 54 0501017

N4,N4'-Di(pyridin-2-yl)-[1,1'-biphenyl]-4,4'-dicarboxamide

N4,N4'-Di(pyridin-2-yl)-[1,1'-biphenyl]-4,4'-dicarboxamide

  • Catalogue No.:PA 54 0501017

  • CAS :

    723260-09-1

  • Molecular Formula : C24H18N4O2

  • Molecular Weight : 394.43

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PA 54 0501018

(S)-8-Amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazine 7-Oxide

(S)-8-Amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazine 7-Oxide

  • Catalogue No.:PA 54 0501018

  • CAS :

    NA

  • Molecular Formula : C26H23N7O3

  • Molecular Weight : 481.52

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PA 54 0501019

(S)-2-(4-(8-Amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)benzamido)pyridine 1-Oxide

(S)-2-(4-(8-Amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)benzamido)pyridine 1-Oxide

  • Catalogue No.:PA 54 0501019

  • CAS :

    NA

  • Molecular Formula : C26H23N7O3

  • Molecular Weight : 481.52

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PA 54 0501020

(S)-4-(8-Amino-3-(1-nitrosopyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

(S)-4-(8-Amino-3-(1-nitrosopyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

  • Catalogue No.:PA 54 0501020

  • CAS :

    NA

  • Molecular Formula : C22H20N8O2

  • Molecular Weight : 428.46

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PA 54 0501021

Acalabrutinib Benzyl Impurity

Acalabrutinib Benzyl Impurity

  • Catalogue No.:PA 54 0501021

  • CAS :

    NA

  • Molecular Formula : C29H27N7O

  • Molecular Weight : 489.58

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PA 54 0501022

(S)-4-(8-Amino-3-(1-nitrosopyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)benzoic Acid

(S)-4-(8-Amino-3-(1-nitrosopyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)benzoic Acid

  • Catalogue No.:PA 54 0501022

  • CAS :

    NA

  • Molecular Formula : C17H16N6O3

  • Molecular Weight : 352.35

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PA 54 0501023

(S)-4-(8-Amino-3-(pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

(S)-4-(8-Amino-3-(pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

  • Catalogue No.:PA 54 0501023

  • CAS :

    1420478-90-5

  • Molecular Formula : C22H21N7O

  • Molecular Weight : 399.46

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PA 54 0501024

Benzyl (S)-2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

Benzyl (S)-2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

  • Catalogue No.:PA 54 0501024

  • CAS :

    1420478-88-1

  • Molecular Formula : C18H18BrN5O2

  • Molecular Weight : 416.28

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PA 54 0501025

Benzyl (S)-2-(((3-chloropyrazin-2-yl)methyl)carbamoyl)pyrrolidine-1-carboxylate

Benzyl (S)-2-(((3-chloropyrazin-2-yl)methyl)carbamoyl)pyrrolidine-1-carboxylate

  • Catalogue No.:PA 54 0501025

  • CAS :

    1418307-17-1

  • Molecular Formula : C18H19ClN4O3

  • Molecular Weight : 374.83

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PA 54 0501026

Benzyl (S)-2-(8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

Benzyl (S)-2-(8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

  • Catalogue No.:PA 54 0501026

  • CAS :

    1418307-18-2

  • Molecular Formula : C18H17ClN4O2

  • Molecular Weight : 356.81

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PA 54 0501027

Benzyl (S)-2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

Benzyl (S)-2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

  • Catalogue No.:PA 54 0501027

  • CAS :

    1420478-87-0

  • Molecular Formula : C18H16BrClN4O2

  • Molecular Weight : 435.71

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PA 54 0501028

Benzyl (R)-2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

Benzyl (R)-2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

  • Catalogue No.:PA 54 0501028

  • CAS :

    2198380-46-8

  • Molecular Formula : C18H18BrN5O2

  • Molecular Weight : 416.28

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PA 54 0501029

Benzyl (S)-2-(8-aminoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

Benzyl (S)-2-(8-aminoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

  • Catalogue No.:PA 54 0501029

  • CAS :

    2170801-87-1

  • Molecular Formula : C18H19N5O2

  • Molecular Weight : 337.38

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PA 54 0501030

(4-(Pyridin-2-ylcarbamoyl)phenyl)boronic Acid

(4-(Pyridin-2-ylcarbamoyl)phenyl)boronic Acid

  • Catalogue No.:PA 54 0501030

  • CAS :

    850568-25-1

  • Molecular Formula : C12H11BN2O3

  • Molecular Weight : 242.04

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PA 54 0501031

N-(Pyridin-2-yl)benzamide

N-(Pyridin-2-yl)benzamide

  • Catalogue No.:PA 54 0501031

  • CAS :

    4589-12-2

  • Molecular Formula : C12H10N2O

  • Molecular Weight : 198.23

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PA 54 0501032

N-(Pyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

N-(Pyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

  • Catalogue No.:PA 54 0501032

  • CAS :

    1383385-64-5

  • Molecular Formula : C18H21BN2O3

  • Molecular Weight : 324.19

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PA BSC 05054651

Propiolic Acid (BSC)

Propiolic Acid

  • Catalogue No.:PA BSC 05054651

  • CAS :

    471-25-0

  • Molecular Formula : C3H2O2

  • Molecular Weight : 70.05

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PA 54 0501033

(S)-1-bromo-3-(pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-8-amine

(S)-1-bromo-3-(pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-8-amine

  • Catalogue No.:PA 54 0501033

  • CAS :

    2097168-73-3

  • Molecular Formula : C10H12BrN5

  • Molecular Weight : 282.15

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PA 54 0501034

4-(8-Amino-3-(3,4-dihydro-2H-pyrrol-5-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

4-(8-Amino-3-(3,4-dihydro-2H-pyrrol-5-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

  • Catalogue No.:PA 54 0501034

  • CAS :

    2230757-49-8

  • Molecular Formula : C22H19N7O

  • Molecular Weight : 397.44

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