Acalabrutinib is used to treat certain types of cancer. It is a second generation Bruton's tyrosine kinase inhibitor.Reference standards of Acalabrutinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Acalabrutinib
Catalogue No.:PA 54 50000
CAS :
Molecular Formula : C26H23N7O2
Molecular Weight : 465.52
4-(8-Amino-3-(4-(but-2-ynamido)butanoyl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide
Catalogue No.:PA 54 50510
Molecular Formula : C26H23N7O3
Molecular Weight : 481.52
Benzyl (S)-2-(8-amino-6-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate
Catalogue No.:PA 54 0501000
Molecular Formula : C18H18BrN5O2
Molecular Weight : 416.28
Benzyl (S)-2-(8-amino-5-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate
Catalogue No.:PA 54 0501001
(2R)-2-Amino-3-[(E)-3-[(2S)-2-[8-amino-1-[4-(2-pyridylcarbamoyl)phenyl]imidazo [1,5-a]pyrazin-3-yl]pyrrolidin-1-yl]-1-methyl-3-oxo-prop-1-enyl]sulfanyl-propanoic acid
Catalogue No.:PA 54 0501002
Molecular Formula : C29H30N8O4S
Molecular Weight : 586.67
4-[8-Amino-3-[(2S)-1-(3-oxobutanoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-(2-pyridyl)benzamide
Catalogue No.:PA 54 0501003
Molecular Formula : C26H25N7O3
Molecular Weight : 483.53
N-(Pyridin-2-yl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide
Catalogue No.:PA 54 0501004
Molecular Formula : C18H21BN2O3
Molecular Weight : 324.19
N-2-Pyridinyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide
Catalogue No.:PA 54 0501005
(4-[8-Amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]benzoic acid)
Catalogue No.:PA 54 0501006
Molecular Formula : C21H19N5O3
Molecular Weight : 389.42
Acalabrutinib D4
Catalogue No.:PA STI 088915
Molecular Formula : C26H19D4N7O2
Molecular Weight : 469.54
(S)-4-(9-(1-(But-2-ynoyl)pyrrolidin-2-yl)-4-methyl-2-oxo-2H-imidazo[5',1':3,4]pyrazino[1,2-a]pyrimidin-11-yl)-N-(pyridin-2-yl)benzamide
Catalogue No.:PA 54 0501007
Molecular Formula : C30H25N7O3
Molecular Weight : 531.58
4-(8-((4-((S)-2-(8-Amino-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazin-3-yl)pyrrolidin-1-yl)-4-oxobut-2-en-2-yl)amino)-3-((S)-1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide
Catalogue No.:PA 54 0501008
Molecular Formula : C52H46N14O4
Molecular Weight : 931.03
Acalabrutinib 8-Hydroxy Impurity
Catalogue No.:PA 54 0501009
Molecular Formula : C26H22N6O3
Molecular Weight : 466.5
Propiolic Acid
Catalogue No.:PA 54 0501010
Molecular Formula : C3H2O2
Molecular Weight : 70.05
Acalabrutinib M45 Metabolite
Catalogue No.:PA 54 0501011
Molecular Formula : C26H27N7O3
Molecular Weight : 485.55
Acalabrutinib R-Isomer
Catalogue No.:PA 54 0501012
(S)-4-(9-(1-(But-2-ynoyl)pyrrolidin-2-yl)-2-methyl-4-oxo-4H-imidazo[5',1':3,4]pyrazino[1,2-a]pyrimidin-11-yl)-N-(pyridin-2-yl)benzamide
Catalogue No.:PA 54 0501013
Acalabrutinib Acetyl Impurity
Catalogue No.:PA 54 0501014
Molecular Formula : C24H23N7O2
Molecular Weight : 441.5
Benzyl 2-(1-bromo-8-hydroxyimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate
Catalogue No.:PA 54 0501015
Molecular Formula : C18H17BrN4O3
Molecular Weight : 417.26
Benzyl 2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate
Catalogue No.:PA 54 0501016
N4,N4'-Di(pyridin-2-yl)-[1,1'-biphenyl]-4,4'-dicarboxamide
Catalogue No.:PA 54 0501017
Molecular Formula : C24H18N4O2
Molecular Weight : 394.43
(S)-8-Amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazine 7-Oxide
Catalogue No.:PA 54 0501018
(S)-2-(4-(8-Amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)benzamido)pyridine 1-Oxide
Catalogue No.:PA 54 0501019
(S)-4-(8-Amino-3-(1-nitrosopyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide
Catalogue No.:PA 54 0501020
Molecular Formula : C22H20N8O2
Molecular Weight : 428.46
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