Acalabrutinib Maleate and its Impurities

Acalabrutinib maleate is a selective Bruton's tyrosine kinase (BTK) inhibitor used to treat mantle cell lymphoma and chronic lymphocytic leukemia by blocking B-cell receptor signaling. Reference standards of Acalabrutinib Maleate API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.