Afamelanotide and its Impurities

Afamelanotide, sold under the brand name Scenesse, is a synthetic peptide and analogue of α-melanocyte stimulating hormone. It has been used to prevent skin damage from the sun in people with erythropoietic protoporphyria. Reference standards of Afamelanotide API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.