Aficamten and its Impurities
Aficamten is an investigational oral medication developed by Cytokinetics. It belongs to a class of drugs known as cardiac myosin inhibitors, and it is being developed specifically for the treatment of obstructive hypertrophic cardiomyopathy (HCM). Reference standards of Aficamten API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
(R)-1-Methyl-N-(5-(5-methyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-1H-pyrazole-4-carboxamide
(R)-1-Methyl-N-(5-(5-methyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-1H-pyrazole-4-carboxamide
Catalogue No.:PA 01 4141002
CAS :
2364553-12-6
Molecular Formula : C17H17N5O2
Molecular Weight : 323.36
(R,Z)-N-(5-(N'-Hydroxycarbamimidoyl)-2,3-dihydro-1H-inden-1-yl)-1-methyl-1H-pyrazole-4-carboxamide
(R,Z)-N-(5-(N'-Hydroxycarbamimidoyl)-2,3-dihydro-1H-inden-1-yl)-1-methyl-1H-pyrazole-4-carboxamide
Catalogue No.:PA 01 4141003
CAS :
NA
Molecular Formula : C15H17N5O2
Molecular Weight : 299.33
(S)-N-(5-(5-Ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-1-methyl-1H-pyrazole-4-carboxamide
(S)-N-(5-(5-Ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-1-methyl-1H-pyrazole-4-carboxamide
Catalogue No.:PA 01 4141004
CAS :
NA
Molecular Formula : C18H19N5O2
Molecular Weight : 337.38
