alcaftadine and its Impurities
Alcaftadine is a H1 histamine receptor antagonist used for the prevention of itching associated with allergic conjunctivitis. Reference standards of Alcaftadine API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepin-3-yl)methanol
(11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepin-3-yl)methanol
Catalogue No.:PA 01 35510
CAS :
147083-89-4
Molecular Formula : C19H23N3O
Molecular Weight : 309.41


(11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-2,3-diyl)dimethanol
(11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-2,3-diyl)dimethanol
Catalogue No.:PA 01 35530
CAS :
147083-92-9
Molecular Formula : C20H25N3O2
Molecular Weight : 339.43


11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-2,3-dicarbaldehyde
11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-2,3-dicarbaldehyde
Catalogue No.:PA 01 35540
CAS :
2786767-05-1
Molecular Formula : C20H21N3O2
Molecular Weight : 335.41


(11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepin-2-yl)methanol
(11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepin-2-yl)methanol
Catalogue No.:PA 01 35560
CAS :
1507349-79-2
Molecular Formula : C19H23N3O
Molecular Weight : 309.41


11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-2-carboxylic Acid
11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-2-carboxylic Acid
Catalogue No.:PA 01 35580
CAS :
174257-86-4
Molecular Formula : C19H21N3O2
Molecular Weight : 323.39


(E)-11-(3-Hydroxy-1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-3-carbaldehyde
(E)-11-(3-Hydroxy-1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-3-carbaldehyde
Catalogue No.:PA 01 35590
CAS :
NA
Molecular Formula : C19H21N3O2
Molecular Weight : 323.39


(Z)-11-(3-Hydroxy-1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-3-carbaldehyde
(Z)-11-(3-Hydroxy-1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-3-carbaldehyde
Catalogue No.:PA 01 35600
CAS :
NA
Molecular Formula : C19H21N3O2
Molecular Weight : 323.39


(E)-11-(1-Methyl-2,3-dihydropyridin-4(1H)-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-3-carbaldehyde
(E)-11-(1-Methyl-2,3-dihydropyridin-4(1H)-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-3-carbaldehyde
Catalogue No.:PA 01 35610
CAS :
NA
Molecular Formula : C19H19N3O
Molecular Weight : 305.37


(Z)-11-(1-Methyl-2,3-dihydropyridin-4(1H)-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-3-carbaldehyde
(Z)-11-(1-Methyl-2,3-dihydropyridin-4(1H)-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-3-carbaldehyde
Catalogue No.:PA 01 35620
CAS :
NA
Molecular Formula : C19H19N3O
Molecular Weight : 305.37