alogliptin and its Impurities
Alogliptin is prepared as a benzoate salt. It is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4, inhibitor that decreases blood sugar similar to the other. Reference standards of Alogliptin API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
2-((6-Chloro-1',3-dimethyl-2,2',4,6'-tetraoxo-1',3,4,6'-tetrahydro-2H-[1,4'-bipyrimidin]-3'(2'H)-yl)methyl)benzonitrile
2-((6-Chloro-1',3-dimethyl-2,2',4,6'-tetraoxo-1',3,4,6'-tetrahydro-2H-[1,4'-bipyrimidin]-3'(2'H)-yl)methyl)benzonitrile
Catalogue No.:PA 28 43570
CAS :
NA
Molecular Formula : C18H14ClN5O4
Molecular Weight : 399.79
(R)-6-(3-Aminopiperidin-1-yl)-1',3-dimethyl-2H-[1,4'-bipyrimidine]-2,2',4,6'(1'H,3H,3'H)-tetraone
(R)-6-(3-Aminopiperidin-1-yl)-1',3-dimethyl-2H-[1,4'-bipyrimidine]-2,2',4,6'(1'H,3H,3'H)-tetraone
Catalogue No.:PA 28 43600
CAS :
NA
Molecular Formula : C15H20N6O4
Molecular Weight : 348.36
(R)-2-((3-Methyl-6-(3-((1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)piperidin-1-yl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
(R)-2-((3-Methyl-6-(3-((1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)piperidin-1-yl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
Catalogue No.:PA 28 43610
CAS :
NA
Molecular Formula : C23H25N7O4
Molecular Weight : 463.49
(R)-2-(((1-(3-(2-Cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)amino)methyl)benzonitrile
(R)-2-(((1-(3-(2-Cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)amino)methyl)benzonitrile
Catalogue No.:PA 28 43620
CAS :
2749424-28-8
Molecular Formula : C26H26N6O2
Molecular Weight : 454.52
(R)-2-((3-Acetyl-6-(3-aminopiperidin-1-yl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
(R)-2-((3-Acetyl-6-(3-aminopiperidin-1-yl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
Catalogue No.:PA 28 43630
CAS :
2882929-91-9
Molecular Formula : C19H21N5O3
Molecular Weight : 367.4
(R)-N-(1-(3-(2-Cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)acetamide
(R)-N-(1-(3-(2-Cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)acetamide
Catalogue No.:PA 28 43640
CAS :
1108731-49-2
Molecular Formula : C20H23N5O3
Molecular Weight : 381.43
(R)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzoic Acid
(R)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzoic Acid
Catalogue No.:PA 28 43650
CAS :
2748587-69-9
Molecular Formula : C18H22N4O4
Molecular Weight : 358.39
(R)-2-((6-(3-(1,3-Dioxoisoindolin-2-yl)piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
(R)-2-((6-(3-(1,3-Dioxoisoindolin-2-yl)piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
Catalogue No.:PA 28 43660
CAS :
1430222-09-5
Molecular Formula : C26H23N5O4
Molecular Weight : 469.49
(R)-tert-Butyl (1-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)carbamate
(R)-tert-Butyl (1-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)carbamate
Catalogue No.:PA 28 43670
CAS :
1246610-74-1
Molecular Formula : C23H29N5O4
Molecular Weight : 439.51
2-[[3,4-Dihydro-3-methyl-2,4-dioxo-6-[(3R)-3-piperidinylamino]-1(2H)-pyrimidinyl]methyl]-benzonitrile
2-[[3,4-Dihydro-3-methyl-2,4-dioxo-6-[(3R)-3-piperidinylamino]-1(2H)-pyrimidinyl]methyl]-benzonitrile
Catalogue No.:PA 28 0431001
CAS :
2089611-85-6
Molecular Formula : C18H21N5O2
Molecular Weight : 339.4
(S)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
(S)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
Catalogue No.:PA 28 0431003
CAS :
1108732-05-3
Molecular Formula : C18H21N5O2
Molecular Weight : 339.4
(S)-N-(1-(3-(2-Cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)-N-((2-hydroxyethyl)carbamoyl)benzamide
(S)-N-(1-(3-(2-Cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)-N-((2-hydroxyethyl)carbamoyl)benzamide
Catalogue No.:PA 28 0431004
CAS :
2835304-59-9
Molecular Formula : C28H30N6O5
Molecular Weight : 530.59
(S)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile Hydrochloride
(S)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile Hydrochloride
Catalogue No.:PA 28 0431006
CAS :
2749805-81-8
Molecular Formula : C18H22ClN5O2
Molecular Weight : 375.86
(S)-N-(1-(3-(2-Cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)benzamide
(S)-N-(1-(3-(2-Cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)benzamide
Catalogue No.:PA 28 0431009
CAS :
1618644-32-8
Molecular Formula : C25H25N5O3
Molecular Weight : 443.51
2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
Catalogue No.:PA 28 0431010
CAS :
865759-26-8
Molecular Formula : C18H21N5O2
Molecular Weight : 339.4
(R)-2-((3-Methyl-6-(3-(5-methyl-1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
(R)-2-((3-Methyl-6-(3-(5-methyl-1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
Catalogue No.:PA 28 0431011
CAS :
1638544-56-5
Molecular Formula : C27H25N5O4
Molecular Weight : 483.53
(R)-2-((6-(3-(5-methyl-1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
(R)-2-((6-(3-(5-methyl-1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
Catalogue No.:PA 28 0431015
CAS :
1638544-55-4
Molecular Formula : C26H23N5O4
Molecular Weight : 469.5
(R)-4-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
(R)-4-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
Catalogue No.:PA 28 0431016
CAS :
1638544-62-3
Molecular Formula : C18H21N5O2
Molecular Weight : 339.4
(R)-3-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
(R)-3-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
Catalogue No.:PA 28 0431017
CAS :
1339955-49-5
Molecular Formula : C18H21N5O2
Molecular Weight : 339.4
(R)-N-(3-(2-Cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N-(piperidin-3-yl)nitrous amide
(R)-N-(3-(2-Cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N-(piperidin-3-yl)nitrous amide
Catalogue No.:PA 28 0431023
CAS :
NA
Molecular Formula : C18H20N6O3
Molecular Weight : 368.4
2-((6-(3-Aminopiperidin-1-yl)-5-hydroxy-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
2-((6-(3-Aminopiperidin-1-yl)-5-hydroxy-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
Catalogue No.:PA 28 0431024
CAS :
1949773-39-0
Molecular Formula : C18H21N5O3
Molecular Weight : 355.4
tert-Butyl (R)-(1-(3-(2-cyanobenzyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)carbamate
tert-Butyl (R)-(1-(3-(2-cyanobenzyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)carbamate
Catalogue No.:PAI 28 043001
CAS :
NA
Molecular Formula : C22H27N5O4
Molecular Weight : 425.49
tert-Butyl (R)-(1-(1-acetyl-3-(2-cyanobenzyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)carbamate
tert-Butyl (R)-(1-(1-acetyl-3-(2-cyanobenzyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)carbamate
Catalogue No.:PAI 28 043003
CAS :
NA
Molecular Formula : C24H29N5O5
Molecular Weight : 467.53
(R)-2-((6-(3-((Diphenylmethylene)amino)piperidin-1-yl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
(R)-2-((6-(3-((Diphenylmethylene)amino)piperidin-1-yl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
Catalogue No.:PAI 28 043004
CAS :
NA
Molecular Formula : C30H27N5O2
Molecular Weight : 489.58