alprostadil and its Impurities
Alprostadil is produced endogenously and causes vasodilation by means of a direct effect on vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth. It is also used in maintaining a patent ductus arteriosus in newborns. Reference standards of Alprostadil API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
(1R,2S,3R,5S)-5-Acetyloxy-2-hydroxymethyl-3-tetrahydropyranyloxy-α-(phenylseleno)cyclopentaneheptanoic Acid Methyl Ester (Mixture of Diastereomers)
(1R,2S,3R,5S)-5-Acetyloxy-2-hydroxymethyl-3-tetrahydropyranyloxy-α-(phenylseleno)cyclopentaneheptanoic Acid Methyl Ester (Mixture of Diastereomers)
Catalogue No.:PA 28 39510
CAS :
61302-47-4
Molecular Formula : C21H36O7
Molecular Weight : 400.51
(3aR,4R,5R,6aS)-4-[3-(Ethyleneketal)decanyl]hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-one
(3aR,4R,5R,6aS)-4-[3-(Ethyleneketal)decanyl]hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-one
Catalogue No.:PA 28 0391001
CAS :
118696-65-4
Molecular Formula : C19H32O5
Molecular Weight : 340.46
(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)cyclopentyl)hept-5-enoic acid
(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)cyclopentyl)hept-5-enoic acid
Catalogue No.:PA 28 0391003
CAS :
551-11-1
Molecular Formula : C20H34O5
Molecular Weight : 354.49
(E)-7-((1R,2R,3R)-3-((Tert-butyldimethylsilyl)oxy)-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic Acid
(E)-7-((1R,2R,3R)-3-((Tert-butyldimethylsilyl)oxy)-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic Acid
Catalogue No.:PAI 28 039001
CAS :
NA
Molecular Formula : C26H46O5Si
Molecular Weight : 466.73
Methyl (E)-7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoate
Methyl (E)-7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoate
Catalogue No.:PAI 28 039002
CAS :
104012-07-9
Molecular Formula : C21H34O5
Molecular Weight : 366.5
