alvimopan and its Impurities
Alvimopan is used to avoid postoperative ileus following small or large bowel resection and accelerates the gastrointestinal recovery period.It is a peripherally acting μ opioid antagonist. Reference standards of Alvimopan API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


2-((R)-2-Benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetic Acid
2-((R)-2-Benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetic Acid
Catalogue No.:PA 28 13620
CAS :
342639-35-4
Molecular Formula : C25H32N2O4
Molecular Weight : 424.53


2-((S)-2-Benzyl-3-((3S,4S)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetic Acid
2-((S)-2-Benzyl-3-((3S,4S)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetic Acid
Catalogue No.:PA 28 13630
CAS :
NA
Molecular Formula : C25H32N2O4
Molecular Weight : 424.53


2-((R)-2-Benzyl-3-((3S,4S)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetic Acid
2-((R)-2-Benzyl-3-((3S,4S)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetic Acid
Catalogue No.:PA 28 13640
CAS :
156130-44-8
Molecular Formula : C25H32N2O4
Molecular Weight : 424.53


2-((S)-2-(((3R,4R)-4-(4-Bromo-3-hydroxyphenyl)-3-4-dimethylpiperidin-1-yl)methyl)-3-phenylpropanamido)acetic Acid
2-((S)-2-(((3R,4R)-4-(4-Bromo-3-hydroxyphenyl)-3-4-dimethylpiperidin-1-yl)methyl)-3-phenylpropanamido)acetic Acid
Catalogue No.:PA 28 13670
CAS :
NA
Molecular Formula : C25H31BrN2O4
Molecular Weight : 503.44


(alphaS,3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-alpha-(phenylmethyl)-1-piperidinepropanoic acid methyl ester
(alphaS,3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-alpha-(phenylmethyl)-1-piperidinepropanoic acid methyl ester
Catalogue No.:PA 28 0131000
CAS :
170098-29-0
Molecular Formula : C24H31NO3
Molecular Weight : 381.52


Ethyl ((S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoyl)glycinate hydrochloride
Ethyl ((S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoyl)glycinate hydrochloride
Catalogue No.:PA 28 0131003
CAS :
NA
Molecular Formula : C27H37ClN2O4
Molecular Weight : 489.05


Methyl (Z)-2-(((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)methyl)-3-phenylacrylate hydrochloride
Methyl (Z)-2-(((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)methyl)-3-phenylacrylate hydrochloride
Catalogue No.:PA 28 0131005
CAS :
1420776-96-0
Molecular Formula : C24H30ClNO3
Molecular Weight : 415.96


Ethyl ((S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoyl)glycinate
Ethyl ((S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoyl)glycinate
Catalogue No.:PA 28 0131006
CAS :
660848-91-9
Molecular Formula : C27H36N2O4
Molecular Weight : 452.6


Methyl ((R)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoyl)glycinate
Methyl ((R)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoyl)glycinate
Catalogue No.:PA 28 0131009
CAS :
NA
Molecular Formula : C26H34N2O4
Molecular Weight : 438.57


Methyl (R)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoate Hydrochloride
Methyl (R)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoate Hydrochloride
Catalogue No.:PA 28 0131012
CAS :
170098-42-7
Molecular Formula : C24H32ClNO3
Molecular Weight : 417.97