Apalutamide and its Impurities

Apalutamide, sold under the brand name Erleada among others, is a nonsteroidal antiandrogen medication which is used in the treatment of prostate cancer. It is specifically indicated for use in conjunction with castration in the treatment of non-metastatic castration-resistant prostate cancer Reference standards of Apalutamide API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

Displaying 38 results for Apalutamide Impurities
Drug Reference Standards & Impurity Synthesis in India
PA 01 2920000

Apalutamide

Apalutamide

  • Catalogue No.:PA 01 2920000

  • CAS :

    956104-40-8

  • Molecular Formula : C21H15F4N5O2S

  • Molecular Weight : 477.44

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921000

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzamide

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzamide

  • Catalogue No.:PA 01 2921000

  • CAS :

    1332391-11-3

  • Molecular Formula : C20H13F4N5O2S

  • Molecular Weight : 463.41

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921001

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-6,8-dioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-6,8-dioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide

  • Catalogue No.:PA 01 2921001

  • CAS :

    1332391-92-0

  • Molecular Formula : C21H15F4N5O3

  • Molecular Weight : 461.38

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921002

5-(5-(3-Fluoro-4-(methylcarbamoyl)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinamide

5-(5-(3-Fluoro-4-(methylcarbamoyl)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinamide

  • Catalogue No.:PA 01 2921002

  • CAS :

    NA

  • Molecular Formula : C21H17F4N5O3S

  • Molecular Weight : 495.45

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921003

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-6,8-dithioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-6,8-dithioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide

  • Catalogue No.:PA 01 2921003

  • CAS :

    2649802-40-2

  • Molecular Formula : C21H15F4N5OS2

  • Molecular Weight : 493.5

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921004

4-((1-Cyanocyclobutyl)amino)-2-fluoro-N-methylbenzamide

4-((1-Cyanocyclobutyl)amino)-2-fluoro-N-methylbenzamide

  • Catalogue No.:PA 01 2921004

  • CAS :

    915087-26-2

  • Molecular Formula : C13H14FN3O

  • Molecular Weight : 247.27

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921005

4-((1-((6-Cyano-5-(trifluoromethyl)pyridin-3-yl)carbamoyl)cyclobutyl)amino)-2-fluoro-N-methylbenzamide

4-((1-((6-Cyano-5-(trifluoromethyl)pyridin-3-yl)carbamoyl)cyclobutyl)amino)-2-fluoro-N-methylbenzamide

  • Catalogue No.:PA 01 2921005

  • CAS :

    1950587-20-8

  • Molecular Formula : C20H17F4N5O2

  • Molecular Weight : 435.38

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921006

1-[3-Fluoro-4-(methylcarbamoyl)anilino]cyclobutane-1-carboxylic acid

1-[3-Fluoro-4-(methylcarbamoyl)anilino]cyclobutane-1-carboxylic acid

  • Catalogue No.:PA 01 2921006

  • CAS :

    2227589-22-0

  • Molecular Formula : C13H15FN2O3

  • Molecular Weight : 266.27

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921007

1-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)thiourea

1-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)thiourea

  • Catalogue No.:PA 01 2921007

  • CAS :

    2422147-84-8

  • Molecular Formula : C8H5F3N4S

  • Molecular Weight : 246.21

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921008

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3,4]octan-5-yl)-2-fluorobenzoic acid

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3,4]octan-5-yl)-2-fluorobenzoic acid

  • Catalogue No.:PA 01 2921008

  • CAS :

    1332391-04-4

  • Molecular Formula : C20H12F4N4O3S

  • Molecular Weight : 464.39

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Drug Reference Standards & Impurity Synthesis in India
PA STI 088917

Apalutamide D3

Apalutamide D3

  • Catalogue No.:PA STI 088917

  • CAS :

    1638885-61-6

  • Molecular Formula : C21H12D3F4N5O2S

  • Molecular Weight : 480.46

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Drug Reference Standards & Impurity Synthesis in India
PA STI 088918

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-(methyl-13C-d3)benzamide

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-(methyl-13C-d3)benzamide

  • Catalogue No.:PA STI 088918

  • CAS :

    NA

  • Molecular Formula : C2013CH12D3F4N5O2S

  • Molecular Weight : 481.45

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921009

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-N-methylbenzamide

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-N-methylbenzamide

  • Catalogue No.:PA 01 2921009

  • CAS :

    1332389-57-7

  • Molecular Formula : C21H16F3N5O2S

  • Molecular Weight : 459.45

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921010

2-Fluoro-4-(hydroxyamino)-N-methylbenzamide

2-Fluoro-4-(hydroxyamino)-N-methylbenzamide

  • Catalogue No.:PA 01 2921010

  • CAS :

    NA

  • Molecular Formula : C8H9FN2O2

  • Molecular Weight : 184.17

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921011

5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile

5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile

  • Catalogue No.:PA 01 2921011

  • CAS :

    573762-62-6

  • Molecular Formula : C7H4F3N3

  • Molecular Weight : 187.13

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921012

2-Bromo-5-Nitro-3-(Trifluoromethyl)Pyridine

2-Bromo-5-Nitro-3-(Trifluoromethyl)Pyridine

  • Catalogue No.:PA 01 2921012

  • CAS :

    956104-42-0

  • Molecular Formula : C6H2BrF3N2O2

  • Molecular Weight : 270.99

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921013

4-Amino-N-methylbenzamide

4-Amino-N-methylbenzamide

  • Catalogue No.:PA 01 2921013

  • CAS :

    6274-22-2

  • Molecular Formula : C8H10N2O

  • Molecular Weight : 150.18

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921014

2-Fluoro-4-nitrotoluene

2-Fluoro-4-nitrotoluene

  • Catalogue No.:PA 01 2921014

  • CAS :

    1427-07-2

  • Molecular Formula : C7H6FNO2

  • Molecular Weight : 155.13

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921015

4-Amino-2-fluorobenzoic Acid

4-Amino-2-fluorobenzoic Acid

  • Catalogue No.:PA 01 2921015

  • CAS :

    446-31-1

  • Molecular Formula : C7H6FNO2

  • Molecular Weight : 155.13

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921017

O-Phenyl (4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoyl)(methyl)carbamothioate

O-Phenyl (4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoyl)(methyl)carbamothioate

  • Catalogue No.:PA 01 2921017

  • CAS :

    NA

  • Molecular Formula : C28H19F4N5O3S2

  • Molecular Weight : 613.61

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921016

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-N-(1-((6-cyano-5-(trifluoromethyl)pyridin-3-yl)carbamoyl)cyclobutyl)-2-fluoro-N-(3-fluoro-4-(methylcarbamoyl)phenyl)benzamide

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-N-(1-((6-cyano-5-(trifluoromethyl)pyridin-3-yl)carbamoyl)cyclobutyl)-2-fluoro-N-(3-fluoro-4-(methylcarbamoyl)phenyl)benzamide

  • Catalogue No.:PA 01 2921016

  • CAS :

    NA

  • Molecular Formula : C40H27F8N9O4S

  • Molecular Weight : 881.76

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921018

1-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)Cyclobutane-1-Carboxylic Acid, Potassium Salt (1:1)

1-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)cyclobutane-1-carboxylic acid, potassium salt (1:1)

  • Catalogue No.:PA 01 2921018

  • CAS :

    2408380-71-0

  • Molecular Formula : C13H14FKN2O3

  • Molecular Weight : 304.36

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921019

Sodium 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate

Sodium 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate

  • Catalogue No.:PA 01 2921019

  • CAS :

    NA

  • Molecular Formula : C20H11F4N4NaO3S

  • Molecular Weight : 486.38

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921020

Methyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate

Methyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate

  • Catalogue No.:PA 01 2921020

  • CAS :

    1950587-19-5

  • Molecular Formula : C21H14F4N4O3S

  • Molecular Weight : 478.42

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921021

Ethyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate

Ethyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate

  • Catalogue No.:PA 01 2921021

  • CAS :

    1332388-83-6

  • Molecular Formula : C22H16F4N4O3S

  • Molecular Weight : 492.45

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921022

1-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)urea

1-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)urea

  • Catalogue No.:PA 01 2921022

  • CAS :

    NA

  • Molecular Formula : C8H5F3N4O

  • Molecular Weight : 230.15

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921023

4-((1-Cyanocyclobutyl)(nitroso)amino)-2-fluoro-N-methylbenzamide

4-((1-Cyanocyclobutyl)(nitroso)amino)-2-fluoro-N-methylbenzamide

  • Catalogue No.:PA 01 2921023

  • CAS :

    NA

  • Molecular Formula : C13H13FN4O2

  • Molecular Weight : 276.27

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921024

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-(3-fluoro-4-(methylcarbamoyl)phenyl)-N-methylbenzamide

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-(3-fluoro-4-(methylcarbamoyl)phenyl)-N-methylbenzamide

  • Catalogue No.:PA 01 2921024

  • CAS :

    2894796-76-8

  • Molecular Formula : C29H21F5N6O3S

  • Molecular Weight : 628.58

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Drug Reference Standards & Impurity Synthesis in India
PAI 01 292001

tert-Butyl (1-((6-cyano-5-(trifluoromethyl)pyridin-3-yl)carbamoyl)cyclobutyl)carbamate

tert-Butyl (1-((6-cyano-5-(trifluoromethyl)pyridin-3-yl)carbamoyl)cyclobutyl)carbamate

  • Catalogue No.:PAI 01 292001

  • CAS :

    1950587-16-2

  • Molecular Formula : C17H19F3N4O3

  • Molecular Weight : 384.36

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Drug Reference Standards & Impurity Synthesis in India
PAI 01 292002

Ethyl 1-((tert-butoxycarbonyl)amino)cyclobutane-1-carboxylate

Ethyl 1-((tert-butoxycarbonyl)amino)cyclobutane-1-carboxylate

  • Catalogue No.:PAI 01 292002

  • CAS :

    163554-54-9

  • Molecular Formula : C12H21NO4

  • Molecular Weight : 243.3

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Drug Reference Standards & Impurity Synthesis in India
PAI 01 292003

Ethyl 1-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)cyclobutane-1-carboxylate

Ethyl 1-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)cyclobutane-1-carboxylate

  • Catalogue No.:PAI 01 292003

  • CAS :

    2230023-67-1

  • Molecular Formula : C15H19FN2O3

  • Molecular Weight : 294.33

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Drug Reference Standards & Impurity Synthesis in India
PA STI 089835

Apalutamide D7

Apalutamide D7

  • Catalogue No.:PA STI 089835

  • CAS :

    NA

  • Molecular Formula : C21H8D7F4N5O2S

  • Molecular Weight : 484.48

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921025

N-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)nitrous amide

N-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)nitrous amide

  • Catalogue No.:PA 01 2921025

  • CAS :

    NA

  • Molecular Formula : C7H3F3N4O

  • Molecular Weight : 216.12

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921026

1-((3-Fluoro-4-(methylcarbamoyl)phenyl)(nitroso)amino)cyclobutane-1-carboxylic acid

1-((3-Fluoro-4-(methylcarbamoyl)phenyl)(nitroso)amino)cyclobutane-1-carboxylic acid

  • Catalogue No.:PA 01 2921026

  • CAS :

    NA

  • Molecular Formula : C13H14FN3O4

  • Molecular Weight : 295.27

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921027

2-Fluoro-N-methyl-4-(nitrosoamino)benzamide

2-Fluoro-N-methyl-4-(nitrosoamino)benzamide

  • Catalogue No.:PA 01 2921027

  • CAS :

    NA

  • Molecular Formula : C8H8FN3O2

  • Molecular Weight : 197.17

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921028

4-(N-(1-((6-Cyano-5-(trifluoromethyl)pyridin-3-yl)carbamoyl)cyclobutyl)formamido)-2-fluoro-N-methylbenzamide

4-(N-(1-((6-Cyano-5-(trifluoromethyl)pyridin-3-yl)carbamoyl)cyclobutyl)formamido)-2-fluoro-N-methylbenzamide

  • Catalogue No.:PA 01 2921028

  • CAS :

    NA

  • Molecular Formula : C21H17F4N5O3

  • Molecular Weight : 463.39

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921029

Apalutamide N-Oxide

Apalutamide N-Oxide

  • Catalogue No.:PA 01 2921029

  • CAS :

    NA

  • Molecular Formula : C21H15F4N5O3S

  • Molecular Weight : 493.44

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Drug Reference Standards & Impurity Synthesis in India
PA 01 2921030

5-Isothiocyanato-3-(trifluoromethyl)picolinonitrile

5-Isothiocyanato-3-(trifluoromethyl)picolinonitrile

  • Catalogue No.:PA 01 2921030

  • CAS :

    951753-87-0

  • Molecular Formula : C8H2F3N3S

  • Molecular Weight : 229.18

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