Apalutamide, sold under the brand name Erleada among others, is a nonsteroidal antiandrogen medication which is used in the treatment of prostate cancer. It is specifically indicated for use in conjunction with castration in the treatment of non-metastatic castration-resistant prostate cancer Reference standards of Apalutamide API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Apalutamide
Catalogue No.:PA 01 2920000
CAS :
Molecular Formula : C21H15F4N5O2S
Molecular Weight : 477.44
4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzamide
Catalogue No.:PA 01 2921000
Molecular Formula : C20H13F4N5O2S
Molecular Weight : 463.41
4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-6,8-dioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide
Catalogue No.:PA 01 2921001
Molecular Formula : C21H15F4N5O3
Molecular Weight : 461.38
5-(5-(3-Fluoro-4-(methylcarbamoyl)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinamide
Catalogue No.:PA 01 2921002
Molecular Formula : C21H17F4N5O3S
Molecular Weight : 495.45
4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-6,8-dithioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide
Catalogue No.:PA 01 2921003
Molecular Formula : C21H15F4N5OS2
Molecular Weight : 493.5
4-((1-Cyanocyclobutyl)amino)-2-fluoro-N-methylbenzamide
Catalogue No.:PA 01 2921004
Molecular Formula : C13H14FN3O
Molecular Weight : 247.27
4-((1-((6-Cyano-5-(trifluoromethyl)pyridin-3-yl)carbamoyl)cyclobutyl)amino)-2-fluoro-N-methylbenzamide
Catalogue No.:PA 01 2921005
Molecular Formula : C20H17F4N5O2
Molecular Weight : 435.38
1-[3-Fluoro-4-(methylcarbamoyl)anilino]cyclobutane-1-carboxylic acid
Catalogue No.:PA 01 2921006
Molecular Formula : C13H15FN2O3
Molecular Weight : 266.27
1-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)thiourea
Catalogue No.:PA 01 2921007
Molecular Formula : C8H5F3N4S
Molecular Weight : 246.21
4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3,4]octan-5-yl)-2-fluorobenzoic acid
Catalogue No.:PA 01 2921008
Molecular Formula : C20H12F4N4O3S
Molecular Weight : 464.39
Apalutamide D3
Catalogue No.:PA STI 088917
Molecular Formula : C21H12D3F4N5O2S
Molecular Weight : 480.46
4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-(methyl-13C-d3)benzamide
Catalogue No.:PA STI 088918
Molecular Formula : C2013CH12D3F4N5O2S
Molecular Weight : 481.45
4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-N-methylbenzamide
Catalogue No.:PA 01 2921009
Molecular Formula : C21H16F3N5O2S
Molecular Weight : 459.45
2-Fluoro-4-(hydroxyamino)-N-methylbenzamide
Catalogue No.:PA 01 2921010
Molecular Formula : C8H9FN2O2
Molecular Weight : 184.17
5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile
Catalogue No.:PA 01 2921011
Molecular Formula : C7H4F3N3
Molecular Weight : 187.13
2-Bromo-5-Nitro-3-(Trifluoromethyl)Pyridine
Catalogue No.:PA 01 2921012
Molecular Formula : C6H2BrF3N2O2
Molecular Weight : 270.99
4-Amino-N-methylbenzamide
Catalogue No.:PA 01 2921013
Molecular Formula : C8H10N2O
Molecular Weight : 150.18
2-Fluoro-4-nitrotoluene
Catalogue No.:PA 01 2921014
Molecular Formula : C7H6FNO2
Molecular Weight : 155.13
4-Amino-2-fluorobenzoic Acid
Catalogue No.:PA 01 2921015
O-Phenyl (4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoyl)(methyl)carbamothioate
Catalogue No.:PA 01 2921017
Molecular Formula : C28H19F4N5O3S2
Molecular Weight : 613.61
4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-N-(1-((6-cyano-5-(trifluoromethyl)pyridin-3-yl)carbamoyl)cyclobutyl)-2-fluoro-N-(3-fluoro-4-(methylcarbamoyl)phenyl)benzamide
Catalogue No.:PA 01 2921016
Molecular Formula : C40H27F8N9O4S
Molecular Weight : 881.76
1-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)cyclobutane-1-carboxylic acid, potassium salt (1:1)
Catalogue No.:PA 01 2921018
Molecular Formula : C13H14FKN2O3
Molecular Weight : 304.36
Sodium 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate
Catalogue No.:PA 01 2921019
Molecular Formula : C20H11F4N4NaO3S
Molecular Weight : 486.38
Methyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate
Catalogue No.:PA 01 2921020
Molecular Formula : C21H14F4N4O3S
Molecular Weight : 478.42
Ethyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate
Catalogue No.:PA 01 2921021
Molecular Formula : C22H16F4N4O3S
Molecular Weight : 492.45
1-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)urea
Catalogue No.:PA 01 2921022
Molecular Formula : C8H5F3N4O
Molecular Weight : 230.15
4-((1-Cyanocyclobutyl)(nitroso)amino)-2-fluoro-N-methylbenzamide
Catalogue No.:PA 01 2921023
Molecular Formula : C13H13FN4O2
Molecular Weight : 276.27
4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-(3-fluoro-4-(methylcarbamoyl)phenyl)-N-methylbenzamide
Catalogue No.:PA 01 2921024
Molecular Formula : C29H21F5N6O3S
Molecular Weight : 628.58
tert-Butyl (1-((6-cyano-5-(trifluoromethyl)pyridin-3-yl)carbamoyl)cyclobutyl)carbamate
Catalogue No.:PAI 01 292001
Molecular Formula : C17H19F3N4O3
Molecular Weight : 384.36
Ethyl 1-((tert-butoxycarbonyl)amino)cyclobutane-1-carboxylate
Catalogue No.:PAI 01 292002
Molecular Formula : C12H21NO4
Molecular Weight : 243.3
Ethyl 1-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)cyclobutane-1-carboxylate
Catalogue No.:PAI 01 292003
Molecular Formula : C15H19FN2O3
Molecular Weight : 294.33
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