argatroban and its Impurities
The American College of Cardiologists recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia and are undergoing percutaneous coronary intervention. It is a direct, selective thrombin inhibitor.. Reference standards of Argatroban API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
(2S,4S)-1-[(2S)-2-Amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic Acid Benzyl Ester Hydrochloride
(2S,4S)-1-[(2S)-2-Amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic Acid Benzyl Ester Hydrochloride
Catalogue No.:PA 01 68510
CAS :
NA
Molecular Formula : C20H31ClN6O5
Molecular Weight : 470.95
(2S,4S)-1-[(2S)-2-[(tert-Butyloxycarbonyl)amino]-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic Acid Benzyl Ester
(2S,4S)-1-[(2S)-2-[(tert-Butyloxycarbonyl)amino]-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic Acid Benzyl Ester
Catalogue No.:PA 01 68530
CAS :
NA
Molecular Formula : C25H38N6O7
Molecular Weight : 534.61
(2R,4R)-1-[(2S)-2-[(tert-Butyloxycarbonyl)amino]-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic Acid Benzyl Ester
(2R,4R)-1-[(2S)-2-[(tert-Butyloxycarbonyl)amino]-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic Acid Benzyl Ester
Catalogue No.:PA 01 68540
CAS :
367952-82-7
Molecular Formula : C25H38N6O7
Molecular Weight : 534.61
(2R,4R)-Ethyl 1-((2S)-5-guanidino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylate
(2R,4R)-Ethyl 1-((2S)-5-guanidino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylate
Catalogue No.:PA 01 68620
CAS :
2739760-40-6
Molecular Formula : C25H40N6O5S
Molecular Weight : 536.69
(2R,4R)-1-((2S)-5-Amino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic acid Hydrochloride
(2R,4R)-1-((2S)-5-Amino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic acid Hydrochloride
Catalogue No.:PA 01 68650
CAS :
NA
Molecular Formula : C22H35ClN4O5S
Molecular Weight : 503.06
(2R,4R)-1-((2R)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic Acid
(2R,4R)-1-((2R)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic Acid
Catalogue No.:PA 01 68670
CAS :
NA
Molecular Formula : C23H36N6O5S
Molecular Weight : 508.63
(2R,4S)-1-((2S)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic Acid
(2R,4S)-1-((2S)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic Acid
Catalogue No.:PA 01 68680
CAS :
189264-04-8
Molecular Formula : C23H36N6O5S
Molecular Weight : 508.63
(2S,4R)-1-((2R)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic Acid
(2S,4R)-1-((2R)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic Acid
Catalogue No.:PA 01 68690
CAS :
NA
Molecular Formula : C23H36N6O5S
Molecular Weight : 508.63
(2S,4R)-1-((2S)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic Acid
(2S,4R)-1-((2S)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic Acid
Catalogue No.:PA 01 68700
CAS :
189264-02-6
Molecular Formula : C23H36N6O5S
Molecular Weight : 508.63
(2R,4S)-1-((2R)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic Acid
(2R,4S)-1-((2R)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic Acid
Catalogue No.:PA 01 68710
CAS :
NA
Molecular Formula : C23H36N6O5S
Molecular Weight : 508.63
(2R,4R)1-[(2S)2-Amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic Acid Ethyl Ester Hydrochloride
(2R,4R)1-[(2S)2-Amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic Acid Ethyl Ester Hydrochloride
Catalogue No.:PA 01 68730
CAS :
74874-08-1
Molecular Formula : C15H29ClN6O5
Molecular Weight : 408.88
(2R,4R)-4-Methyl-1-((2S)-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)-5-(3-nitroguanidino)pentanoyl)piperidine-2-carboxylic Acid
(2R,4R)-4-Methyl-1-((2S)-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)-5-(3-nitroguanidino)pentanoyl)piperidine-2-carboxylic Acid
Catalogue No.:PA 01 68740
CAS :
1448301-07-2
Molecular Formula : C23H35N7O7S
Molecular Weight : 553.63
Argatroban Related Compound B (Ethyl (4R)-1-[N^8-nitro-L-arginyl]-4-methylpiperidine-2-carboxylate (1042420)
Argatroban Related Compound B (Ethyl (4R)-1-[N^8-nitro-L-arginyl]-4-methylpiperidine-2-carboxylate (1042420)
Catalogue No.:PA USP1042420
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA
Argatroban Related Compound C ((2R,4R)-1-[N^8-amino- N^2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-su (1042437)
Argatroban Related Compound C ((2R,4R)-1-[N^8-amino- N^2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-su (1042437)
Catalogue No.:PA USP1042437
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA
Argatroban Related Compound A ((2R,4R)-1-[N8-nitro- N2-(3-methylquinoline-8-sulfonyl)-L-arginyl]-4- (1042419)
Argatroban Related Compound A ((2R,4R)-1-[N8-nitro- N2-(3-methylquinoline-8-sulfonyl)-L-arginyl]-4- (1042419)
Catalogue No.:PA USP1042419
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA
(2S,4S)-4-Methyl-1-(((3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl)-D-arginyl)piperidine-2-carboxylic Acid
(2S,4S)-4-Methyl-1-(((3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl)-D-arginyl)piperidine-2-carboxylic Acid
Catalogue No.:PA 01 68750
CAS :
NA
Molecular Formula : C23H36N6O5S
Molecular Weight : 508.64
(2R,4R)-4-Methyl-1-(((3-methylquinolin-8-yl)sulfonyl)-L-arginyl)piperidine-2-carboxylic Acid
(2R,4R)-4-Methyl-1-(((3-methylquinolin-8-yl)sulfonyl)-L-arginyl)piperidine-2-carboxylic Acid
Catalogue No.:PA 01 68760
CAS :
951130-92-0
Molecular Formula : C23H32N6O5S
Molecular Weight : 504.61
(2R,4R)-1-((2S)-5-Amino-2-((3-methyl-1,2,3,4-tetrahydroquinoline)-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic Acid
(2R,4R)-1-((2S)-5-Amino-2-((3-methyl-1,2,3,4-tetrahydroquinoline)-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic Acid
Catalogue No.:PA 01 68770
CAS :
188659-43-0
Molecular Formula : C22H34N4O5S
Molecular Weight : 466.6
Ethyl (2R,4R)-1-(N2-(tert-butoxycarbonyl)-Nω-nitro-L-arginyl)-4-methylpiperidine-2-carboxylate
Ethyl (2R,4R)-1-(N2-(tert-butoxycarbonyl)-Nω-nitro-L-arginyl)-4-methylpiperidine-2-carboxylate
Catalogue No.:PA 01 0681004
CAS :
74874-07-0
Molecular Formula : C20H36N6O7
Molecular Weight : 472.54
(2R,4R)-1-((2S)-5-(Hydrazinecarboximidamido)-2-((3-methyl-1,2,3,4-tetrahydroquinoline)-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic Acid
(2R,4R)-1-((2S)-5-(Hydrazinecarboximidamido)-2-((3-methyl-1,2,3,4-tetrahydroquinoline)-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic Acid
Catalogue No.:PA 01 0681007
CAS :
NA
Molecular Formula : C23H37N7O5S
Molecular Weight : 523.65
(2R,4R)-1-((S)-5-(Hydrazinecarboximidamido)-2-((3-methylquinoline)-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic Acid
(2R,4R)-1-((S)-5-(Hydrazinecarboximidamido)-2-((3-methylquinoline)-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic Acid
Catalogue No.:PA 01 0681008
CAS :
NA
Molecular Formula : C23H33N7O5S
Molecular Weight : 519.62
(2R,4R)-4-Methyl-1-((2S)-2-((3-methyl-1,2,3,4-tetrahydroquinoline)-8-sulfonamido)-5-ureidopentanoyl)piperidine-2-carboxylic Acid
(2R,4R)-4-Methyl-1-((2S)-2-((3-methyl-1,2,3,4-tetrahydroquinoline)-8-sulfonamido)-5-ureidopentanoyl)piperidine-2-carboxylic Acid
Catalogue No.:PA 01 0681009
CAS :
2423016-01-5
Molecular Formula : C23H35N5O6S
Molecular Weight : 509.62
(1S,5R)-2-((2S)-8-Amino-7-imino-2-((3-methyl-1,2,3,4-tetrahydroquinoline)-8-sulfonamido)octanoyl)-5-methylcyclohexane-1-carboxylic Acid
(1S,5R)-2-((2S)-8-Amino-7-imino-2-((3-methyl-1,2,3,4-tetrahydroquinoline)-8-sulfonamido)octanoyl)-5-methylcyclohexane-1-carboxylic Acid
Catalogue No.:PA 01 0681013
CAS :
NA
Molecular Formula : C23H37N7O5S
Molecular Weight : 523.65
(2R,4R)-4-Methyl-1-(((3-methyl-1-nitroso-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl)-L-arginyl)piperidine-2-carboxylic Acid
(2R,4R)-4-Methyl-1-(((3-methyl-1-nitroso-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl)-L-arginyl)piperidine-2-carboxylic Acid
Catalogue No.:PA 01 0681015
CAS :
NA
Molecular Formula : C23H35N7O6S
Molecular Weight : 537.64
(2R,4S)-4-Methyl-1-(((3-methyl-1-nitroso-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl)-L-arginyl)piperidine-2-carboxylic Acid
(2R,4S)-4-Methyl-1-(((3-methyl-1-nitroso-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl)-L-arginyl)piperidine-2-carboxylic Acid
Catalogue No.:PA 01 0681024
CAS :
NA
Molecular Formula : C23H35N7O6S
Molecular Weight : 537.64
