asenapine and its Impurities
Asenapine has been approved by the FDA for the acute treatment of adults with schizophrenia and acute treatment of manic or mixed episodes associated with bipolar I disorder with or without psychotic features in adults.. Reference standards of Asenapine API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below


(3aS,12bS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole 2-oxide
(3aS,12bS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole 2-oxide
Catalogue No.:PA 01 78560
CAS :
NA
Molecular Formula : C17H16ClNO2
Molecular Weight : 301.77


(3aR,12bS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole 2-oxide
(3aR,12bS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole 2-oxide
Catalogue No.:PA 01 78570
CAS :
NA
Molecular Formula : C17H16ClNO2
Molecular Weight : 301.77


rel-2-Chloro-11-((methylamino)methyl)-10,11-dihydrodibenzo[b,f]oxepine-10-carboxylic Acid
rel-2-Chloro-11-((methylamino)methyl)-10,11-dihydrodibenzo[b,f]oxepine-10-carboxylic Acid
Catalogue No.:PA 01 0781000
CAS :
912356-10-6 (Relative stereochemistry shown)
Molecular Formula : C17H16ClNO3
Molecular Weight : 317.77


rel-8-chloro-11-((Methylamino)methyl)-10,11-dihydrodibenzo[b,f]oxepine-10-carboxylic Acid Hydrochloride
rel-8-chloro-11-((Methylamino)methyl)-10,11-dihydrodibenzo[b,f]oxepine-10-carboxylic Acid Hydrochloride
Catalogue No.:PA 01 0781001
CAS :
912356-00-4
Molecular Formula : C17H17Cl2NO3
Molecular Weight : 354.23


Trans-(+/-)-11-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
Trans-(+/-)-11-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
Catalogue No.:PA 01 0781004
CAS :
129385-59-7
Molecular Formula : C17H14ClNO2
Molecular Weight : 299.75


(3aR,12bR)-rel-11-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino [4,5-c]pyrrol-5-ol
(3aR,12bR)-rel-11-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino [4,5-c]pyrrol-5-ol
Catalogue No.:PA 01 0781005
CAS :
1262639-38-2
Molecular Formula : C17H16ClNO2
Molecular Weight : 301.77


(3aR,12bR)-Rel-11-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino [4,5-c]pyrrol-5-ol 5-(hydrogen sulfate)
(3aR,12bR)-Rel-11-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino [4,5-c]pyrrol-5-ol 5-(hydrogen sulfate)
Catalogue No.:PA 01 0781006
CAS :
1399103-21-9
Molecular Formula : C17H16ClNO5S
Molecular Weight : 381.83


(3aS,12bR)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
(3aS,12bR)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
Catalogue No.:PA 01 0781011
CAS :
1422571-39-8
Molecular Formula : C17H16ClNO
Molecular Weight : 285.77


(3aS,12bS)-2-Methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-5-amine fumarate
(3aS,12bS)-2-Methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-5-amine fumarate
Catalogue No.:PA 01 0781012
CAS :
1688678-60-5
Molecular Formula : C21H22N2O5
Molecular Weight : 382.42


(3aR,12bR)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
(3aR,12bR)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
Catalogue No.:PA 01 0781014
CAS :
135883-15-7
Molecular Formula : C17H16ClNO
Molecular Weight : 285.77


(3aR,12bR)-5-Chloro-2-(methyl-13C-d3)-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole hydrochloride
(3aR,12bR)-5-Chloro-2-(methyl-13C-d3)-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole hydrochloride
Catalogue No.:PA 01 0781015
CAS :
1261392-55-5
Molecular Formula : C1613CH14D3Cl2NO
Molecular Weight : 326.24

![1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro- PA 01 0781016](https://www.pharmaffiliates.com/pimages/PA010781016.jpg)
1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, 2-oxide, (3aR,12bR)-rel-
1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, 2-oxide, (3aR,12bR)-rel-
Catalogue No.:PA 01 0781016
CAS :
1367373-77-0
Molecular Formula : C17H16ClNO2
Molecular Weight : 301.77


2-(5-Chloro-1,3,3a,12b-tetrahydro-2H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-2-yl)-4,5,6-trihydroxytetrahydro-2H-pyran-3-carboxylic acid
2-(5-Chloro-1,3,3a,12b-tetrahydro-2H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-2-yl)-4,5,6-trihydroxytetrahydro-2H-pyran-3-carboxylic acid
Catalogue No.:PA 01 0781017
CAS :
NA
Molecular Formula : C22H22ClNO7
Molecular Weight : 447.87

![(10S,11S)-8-Chloro-11-[(methylamino)methyl]-10,11- PA 01 0781020](https://www.pharmaffiliates.com/pimages/PA010781020.jpg)
(10S,11S)-8-Chloro-11-[(methylamino)methyl]-10,11-dihydrodibenzo[b,f]oxepine-10-carboxylic Acid
(10S,11S)-8-Chloro-11-[(methylamino)methyl]-10,11-dihydrodibenzo[b,f]oxepine-10-carboxylic Acid
Catalogue No.:PA 01 0781020
CAS :
912355-99-8
Molecular Formula : C17H16ClNO3
Molecular Weight : 317.77


rel-(3aR,12bR)-2-Methyl-5-nitro-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole Fumarate
rel-(3aR,12bR)-2-Methyl-5-nitro-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole Fumarate
Catalogue No.:PA 01 0781023
CAS :
1688678-58-1
Molecular Formula : C21H20N2O7
Molecular Weight : 412.4


(3aR,12bR)-11-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
(3aR,12bR)-11-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
Catalogue No.:PA 01 0781025
CAS :
NA
Molecular Formula : C17H14ClNO2
Molecular Weight : 299.75


(3aS,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
(3aS,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
Catalogue No.:PA 01 0781026
CAS :
912356-09-3
Molecular Formula : C17H14ClNO2
Molecular Weight : 299.75