Atogepant and its Impurities
Atogepant is under investigation in clinical trial NCT03855137 (Efficacy, Safety, and Tolerability of Atogepant for the Prevention of Chronic Migraine). Reference standards of Atogepant API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


rel-(3′R)-1′,2′,5,7-Tetrahydro-N-[(3R,5R,6S)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)-3-piperidinyl]-2′-oxospiro[6H-cyclopenta[b]pyridine-6,3′-[3H]pyrrolo[2,3-b]pyridine]-3-carboxamide
rel-(3′R)-1′,2′,5,7-Tetrahydro-N-[(3R,5R,6S)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)-3-piperidinyl]-2′-oxospiro[6H-cyclopenta[b]pyridine-6,3′-[3H]pyrrolo[2,3-b]pyridine]-3-carboxamide
Catalogue No.:PA 01 3311002
CAS :
2733814-47-4
Molecular Formula : C29H23F6N5O3
Molecular Weight : 603.53


N-((3S,5S,6R)-6-Methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)acetamide
N-((3S,5S,6R)-6-Methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)acetamide
Catalogue No.:PA 01 3311003
CAS :
NA
Molecular Formula : C16H16F6N2O2
Molecular Weight : 382.31

![(S)-2'-Oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b] PA 01 3311004](https://www.pharmaffiliates.com/pimages/PA013311004.jpg)
(S)-2'-Oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylic Acid
(S)-2'-Oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylic Acid
Catalogue No.:PA 01 3311004
CAS :
1375541-21-1
Molecular Formula : C15H11N3O3
Molecular Weight : 281.27


(S)-2-Acetamido-N-((3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-3-phenylpropanamide
(S)-2-Acetamido-N-((3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-3-phenylpropanamide
Catalogue No.:PA 01 3311005
CAS :
NA
Molecular Formula : C25H25F6N3O3
Molecular Weight : 529.48


(3S,5S,6R)-3-Amino-6-methyl-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-2-one
(3S,5S,6R)-3-Amino-6-methyl-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-2-one
Catalogue No.:PA 01 3311006
CAS :
1375794-72-1
Molecular Formula : C14H14F6N2O
Molecular Weight : 340.27


(S)-N-((3S,5S,6R)-6-Methyl-2-oxo-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide
(S)-N-((3S,5S,6R)-6-Methyl-2-oxo-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide
Catalogue No.:PA 01 3311007
CAS :
NA
Molecular Formula : C27H22F3N5O3
Molecular Weight : 521.5


Methyl (S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylate
Methyl (S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylate
Catalogue No.:PA 01 3311008
CAS :
NA
Molecular Formula : C16H13N3O3
Molecular Weight : 295.3


(S)-N-((3R,5S,6R)-6-Methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide
(S)-N-((3R,5S,6R)-6-Methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide
Catalogue No.:PA 01 3311009
CAS :
NA
Molecular Formula : C29H23F6N5O3
Molecular Weight : 603.53


(S)-N-((3S,5S,6S)-6-Methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide
(S)-N-((3S,5S,6S)-6-Methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide
Catalogue No.:PA 01 3311010
CAS :
NA
Molecular Formula : C29H23F6N5O3
Molecular Weight : 603.53


(S)-1'-(tert-Butyl)-3-chloro-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
(S)-1'-(tert-Butyl)-3-chloro-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
Catalogue No.:PA 01 3311013
CAS :
1455358-14-1
Molecular Formula : C18H18ClN3O
Molecular Weight : 327.81


1-(tert-Butyl)-3-((5-chloro-3-(chloromethyl)pyridin-2-yl)methyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one
1-(tert-Butyl)-3-((5-chloro-3-(chloromethyl)pyridin-2-yl)methyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one
Catalogue No.:PA 01 3311014
CAS :
1455358-12-9
Molecular Formula : C18H19Cl2N3O
Molecular Weight : 364.27