atorvastatin acid and its Impurities
A lipid lowering agent, Atorvastatin is used in the treatment of cardiovascular diseases.It is a competitive inhibitor of HMG-CoA reductase.It is a pyrrole and heptanoic acid derivative which acts as a ANTICHOLESTEREMIC AGENT that is used to reduce serum levels of LDL-CHOLESTEROL. Reference standards of Atorvastatin Acid API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


Sodium (3S,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
Sodium (3S,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
Catalogue No.:PAI 01 083007
CAS :
1060754-19-9
Molecular Formula : C33H34FN2NaO5
Molecular Weight : 580.63


5-(4-Fluorophenyl)-2-isopropyl-1-(2-((2R,4R)-4-methoxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide
5-(4-Fluorophenyl)-2-isopropyl-1-(2-((2R,4R)-4-methoxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide
Catalogue No.:PAI 01 083008
CAS :
NA
Molecular Formula : C34H35FN2O4
Molecular Weight : 554.66


Atorvastatin Acid - Impurity D
Mixture of (2Ξ,3Ξ)-3-(4-fluorobenzoyl)-2-(2-methylpropanoyl)-N,3-diphenyloxirane-2-carboxamide (D1) and (1Ξ,2Ξ,4Ξ,5Ξ)-4-(4-fluorophenyl)-2,4-dihydroxy-N,5-diphenyl-2-(propan-2-yl)-3,6-dioxabicyclo[3.1.0]hexane-1-carboxamide (D2)
Catalogue No.:PA 01 0830040
CAS :
NA
Molecular Formula : C52H46F2N2O9
Molecular Weight : 880.94


tert-Butyl (R)-2-(2-(4-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-2-hydroxybutyl)-1,3-dioxolan-2-yl)acetate
tert-Butyl (R)-2-(2-(4-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-2-hydroxybutyl)-1,3-dioxolan-2-yl)acetate
Catalogue No.:PAI 01 083012
CAS :
NA
Molecular Formula : C39H45FN2O6
Molecular Weight : 656.8


5-(4-Fluorophenyl)-1-(2-((4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide
5-(4-Fluorophenyl)-1-(2-((4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide
Catalogue No.:PAI 01 083013
CAS :
1072081-29-8
Molecular Formula : C33H33FN2O4
Molecular Weight : 540.64


Atorvastatin Acid - Impurity Q (Calium Salt)
(3R,5R)-7-[5-(4-Fluorophenyl)-2-oxo-4-phenyl-3-(phenylcarbamoyl)-3-(propan-2-yl)-2,3-dihydro-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic Acid Calcium Salt
Catalogue No.:PA 01 0830171
CAS :
1046118-41-5
Molecular Formula : C66H68CaF2N4O12
Molecular Weight : 1187.36


4-(4-Fluorophenyl)-4-hydroxy-2-isopropyl-2-methoxy-N,5-diphenyl-3,6-dioxabicyclo[3.1.0]hexane-1-carboxamide
4-(4-Fluorophenyl)-4-hydroxy-2-isopropyl-2-methoxy-N,5-diphenyl-3,6-dioxabicyclo[3.1.0]hexane-1-carboxamide
Catalogue No.:PA 01 0831020
CAS :
NA
Molecular Formula : C27H26FNO5
Molecular Weight : 463.51


tert-Butyl 2-((4R,6R)-6-(2-(2-((4R,6R)-6-(2-(2-((4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetamido)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetamido)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
tert-Butyl 2-((4R,6R)-6-(2-(2-((4R,6R)-6-(2-(2-((4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetamido)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetamido)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
Catalogue No.:PA 01 0831023
CAS :
NA
Molecular Formula : C34H61N3O10
Molecular Weight : 671.87


tert-Butyl 2-((4R,6R)-6-(2-(2-((4R,6R)-6-(2-(2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetamido)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetamido)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
tert-Butyl 2-((4R,6R)-6-(2-(2-((4R,6R)-6-(2-(2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetamido)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetamido)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
Catalogue No.:PA 01 0831024
CAS :
NA
Molecular Formula : C60H81FN4O11
Molecular Weight : 1053.32


(2R,5R)-2-(((3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoyl)oxy)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl Triacetate
(2R,5R)-2-(((3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoyl)oxy)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl Triacetate
Catalogue No.:PAI 01 083017
CAS :
NA
Molecular Formula : C46H51FN2O14
Molecular Weight : 874.91


Atorvastatin Acid - Impurity B (Calcium Salt)
(3RS,5SR)-7-[2-(4-Fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic Acid Calcium Salt
Catalogue No.:PA 01 0830021
CAS :
840528-19-0
Molecular Formula : C66H70CaF2N4O10
Molecular Weight : 1157.38


(3R,5R)-7-((R)-5-(4-Fluorophenyl)-3-isopropyl-2-oxo-4-phenyl-3-(phenylcarbamoyl)-2,3-dihydro-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic Acid
(3R,5R)-7-((R)-5-(4-Fluorophenyl)-3-isopropyl-2-oxo-4-phenyl-3-(phenylcarbamoyl)-2,3-dihydro-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic Acid
Catalogue No.:PA 01 0831025
CAS :
691844-60-7
Molecular Formula : C33H35FN2O6
Molecular Weight : 574.65


(3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-4-(nitroso(phenyl)carbamoyl)-3-phenyl-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic Acid
(3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-4-(nitroso(phenyl)carbamoyl)-3-phenyl-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic Acid
Catalogue No.:PA 01 0831026
CAS :
NA
Molecular Formula : C33H34FN3O6
Molecular Weight : 587.65


(2S,3S,4S,5R)-2-((Benzyloxy)carbonyl)-6-(((3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoyl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate
(2S,3S,4S,5R)-2-((Benzyloxy)carbonyl)-6-(((3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoyl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate
Catalogue No.:PAI 01 083022
CAS :
NA
Molecular Formula : C52H55FN2O14
Molecular Weight : 951.01


Benzyl (2S,3S,4S,5R)-6-(((3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoyl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate
Benzyl (2S,3S,4S,5R)-6-(((3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoyl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate
Catalogue No.:PAI 01 083023
CAS :
NA
Molecular Formula : C46H49FN2O11
Molecular Weight : 824.9


Calcium 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-5-hydroxy-3-oxoheptanoate
Calcium 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-5-hydroxy-3-oxoheptanoate
Catalogue No.:PA 01 0831028
CAS :
NA
Molecular Formula : C66H64CaF2N4O10
Molecular Weight : 1151.33


(R)-N-((1-Ethylpyrrolidin-2-yl)methyl)-1-(4-fluorophenyl)-5-(pyridin-3-yl)-1H-pyrazole-3-carboxamide
(R)-N-((1-Ethylpyrrolidin-2-yl)methyl)-1-(4-fluorophenyl)-5-(pyridin-3-yl)-1H-pyrazole-3-carboxamide
Catalogue No.:PA 01 0831033
CAS :
NA
Molecular Formula : C22H24FN5O
Molecular Weight : 393.47


(S)-N-((1-Ethylpyrrolidin-2-yl)methyl)-1-(4-fluorophenyl)-5-(pyridin-3-yl)-1H-pyrazole-3-carboxamide
(S)-N-((1-Ethylpyrrolidin-2-yl)methyl)-1-(4-fluorophenyl)-5-(pyridin-3-yl)-1H-pyrazole-3-carboxamide
Catalogue No.:PA 01 0831034
CAS :
NA
Molecular Formula : C22H24FN5O
Molecular Weight : 393.47


N-((5-Cyclopropylpyridin-3-yl)methyl)-3-(4-fluorophenyl)-1-methyl-1H-pyrazole-5-carboxamide
N-((5-Cyclopropylpyridin-3-yl)methyl)-3-(4-fluorophenyl)-1-methyl-1H-pyrazole-5-carboxamide
Catalogue No.:PA 01 0831035
CAS :
2034569-21-4
Molecular Formula : C20H19FN4O
Molecular Weight : 350.4


N-(2-(5-Cyclopropyl-3-(pyridin-2-yl)-1H-pyrazol-1-yl)ethyl)-3-(4-fluorophenyl)-1-methyl-1H-pyrazole-5-carboxamide
N-(2-(5-Cyclopropyl-3-(pyridin-2-yl)-1H-pyrazol-1-yl)ethyl)-3-(4-fluorophenyl)-1-methyl-1H-pyrazole-5-carboxamide
Catalogue No.:PA 01 0831036
CAS :
1796990-04-9
Molecular Formula : C24H23FN6O
Molecular Weight : 430.49


3-(4-Fluorophenyl)-1-methyl-N-((1-methyl-5-(pyridin-2-yl)-1H-pyrazol-3-yl)methyl)-1H-pyrazole-5-carboxamide
3-(4-Fluorophenyl)-1-methyl-N-((1-methyl-5-(pyridin-2-yl)-1H-pyrazol-3-yl)methyl)-1H-pyrazole-5-carboxamide
Catalogue No.:PA 01 0831037
CAS :
1421476-51-8
Molecular Formula : C21H19FN6O
Molecular Weight : 390.42


1-(4-Fluorophenyl)-5-(pyridin-3-yl)-N-(2-(pyrrolidin-1-yl)ethyl)-1H-pyrazole-3-carboxamide
1-(4-Fluorophenyl)-5-(pyridin-3-yl)-N-(2-(pyrrolidin-1-yl)ethyl)-1H-pyrazole-3-carboxamide
Catalogue No.:PA 01 0831038
CAS :
1357826-17-5
Molecular Formula : C21H22FN5O
Molecular Weight : 379.44


1-(4-Fluorophenyl)-N-(3-(2-oxopyrrolidin-1-yl)propyl)-5-(pyridin-3-yl)-1H-pyrazole-3-carboxamide
1-(4-Fluorophenyl)-N-(3-(2-oxopyrrolidin-1-yl)propyl)-5-(pyridin-3-yl)-1H-pyrazole-3-carboxamide
Catalogue No.:PA 01 0831039
CAS :
1357770-85-4
Molecular Formula : C22H22FN5O2
Molecular Weight : 407.45