atorvastatin and its Impurities
A lipid lowering agent, Atorvastatin is used in the treatment of cardiovascular diseases.It is a competitive inhibitor of HMG-CoA reductase.It is a pyrrole and heptanoic acid derivative which acts as a ANTICHOLESTEREMIC AGENT that is used to reduce serum levels of LDL-CHOLESTEROL.Reference standards of Atorvastatin API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(6-{2-[3-(4-Phenylcarbamoyl)-5-(4-fluoro-phenyl)-2-isopropyl- 4-phenyl-d5-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester
(6-{2-[3-(4-Phenylcarbamoyl)-5-(4-fluoro-phenyl)-2-isopropyl- 4-phenyl-d5-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester
Catalogue No.:PA STI 072780
CAS :
265989-34-2
Molecular Formula : C40H42D5FN2O5
Molecular Weight : 659.84


Atorvastatin Related Compound D (Epoxide impurity, or 3-(4-Fluorobenzoyl)-2-isobutyryl-3-phenyl-oxi (1044550)
Atorvastatin Related Compound D (Epoxide impurity, or 3-(4-Fluorobenzoyl)-2-isobutyryl-3-phenyl-oxi (1044550)
Catalogue No.:PA USP1044550
CAS :
148146-51-4
Molecular Formula : NA
Molecular Weight : NA


Atorvastatin Related Compound A (Desfluoro impurity, or (3R,5R)-7-[3-(phenylcarbamoyl)-2-isopropyl- (1044527)
Atorvastatin Related Compound A (Desfluoro impurity, or (3R,5R)-7-[3-(phenylcarbamoyl)-2-isopropyl- (1044527)
Catalogue No.:PA USP1044527
CAS :
433289-83-9
Molecular Formula : NA
Molecular Weight : NA


Atorvastatin Related Compound C (Difluoro impurity, or Calcium (3R,5R)-7-[2,3-Bis(4-fluorophenyl)-5 (1044549)
Atorvastatin Related Compound C (Difluoro impurity, or Calcium (3R,5R)-7-[2,3-Bis(4-fluorophenyl)-5 (1044549)
Catalogue No.:PA USP1044549
CAS :
693793-53-2
Molecular Formula : NA
Molecular Weight : NA


Atorvastatin Related Compound B (3S,5R isomer, or (3S,5R)-7-[3-(phenylcarbamoyl)-5-(4-fluorophenyl) (1044538)
Atorvastatin Related Compound B (3S,5R isomer, or (3S,5R)-7-[3-(phenylcarbamoyl)-5-(4-fluorophenyl) (1044538)
Catalogue No.:PA USP1044538
CAS :
887196-25-0
Molecular Formula : NA
Molecular Weight : NA


Atorvastatin Related Compound H (5-(4-Fluorophenyl)-1-{2-[(2R, 4R)-4-hydroxy-6-oxotetrahydro-2H-pyr (1044582)
Atorvastatin Related Compound H (5-(4-Fluorophenyl)-1-{2-[(2R, 4R)-4-hydroxy-6-oxotetrahydro-2H-pyr (1044582)
Catalogue No.:PA USP1044582
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA


Atorvastatin Related Compound I (tert-Butyl 2-((4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-pheny (1044593)
Atorvastatin Related Compound I (tert-Butyl 2-((4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-pheny (1044593)
Catalogue No.:PA USP1044593
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA


7-(5-(4-Fluorophenyl)-3-isopropyl-2-oxo-4-phenyl-3-(phenylcarbamoyl)-2,3-dihydro-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic Acid
7-(5-(4-Fluorophenyl)-3-isopropyl-2-oxo-4-phenyl-3-(phenylcarbamoyl)-2,3-dihydro-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic Acid
Catalogue No.:PAI 01 006010
CAS :
496060-54-9
Molecular Formula : C33H35FN2O6
Molecular Weight : 574.64


5-(4-Fluorophenyl)-2-isopropyl-1-(2-(4-methyl-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide
5-(4-Fluorophenyl)-2-isopropyl-1-(2-(4-methyl-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide
Catalogue No.:PAI 01 006020
CAS :
NA
Molecular Formula : C34H35FN2O3
Molecular Weight : 538.65


tert-Butyl 2-((4R,6S)-6-(2-(2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
tert-Butyl 2-((4R,6S)-6-(2-(2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
Catalogue No.:PAI 01 006050
CAS :
NA
Molecular Formula : C37H41FN2O5
Molecular Weight : 612.74


tert-Butyl (3R,5R)-3,5-dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl)heptanoate
tert-Butyl (3R,5R)-3,5-dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl)heptanoate
Catalogue No.:PAI 01 006083
CAS :
2588261-36-1
Molecular Formula : C37H44N2O5
Molecular Weight : 596.77


Methyl (R,E)-3-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-2-((2-hydroxy-N,2-dimethylpropyl)sulfonamido)-6-isopropylpyrimidin-5-yl)-5-oxohept-6-enoate
Methyl (R,E)-3-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-2-((2-hydroxy-N,2-dimethylpropyl)sulfonamido)-6-isopropylpyrimidin-5-yl)-5-oxohept-6-enoate
Catalogue No.:PAI 01 006084
CAS :
NA
Molecular Formula : C32H48FN3O7SSi
Molecular Weight : 665.89


Methyl (R,E)-7-(4-(4-fluorophenyl)-2-((2-hydroxy-N,2-dimethylpropyl)sulfonamido)-6-isopropylpyrimidin-5-yl)-3-hydroxy-5-oxohept-6-enoate
Methyl (R,E)-7-(4-(4-fluorophenyl)-2-((2-hydroxy-N,2-dimethylpropyl)sulfonamido)-6-isopropylpyrimidin-5-yl)-3-hydroxy-5-oxohept-6-enoate
Catalogue No.:PAI 01 006085
CAS :
NA
Molecular Formula : C26H34FN3O7S
Molecular Weight : 551.63


Methyl (3R,5S,E)-7-(4-(4-fluorophenyl)-2-((2-hydroxy-N,2-dimethylpropyl)sulfonamido)-6-isopropylpyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate
Methyl (3R,5S,E)-7-(4-(4-fluorophenyl)-2-((2-hydroxy-N,2-dimethylpropyl)sulfonamido)-6-isopropylpyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate
Catalogue No.:PAI 01 006086
CAS :
2101546-12-5
Molecular Formula : C26H36FN3O7S
Molecular Weight : 553.65


Tert-butyl 2-((4R,6R)-6-(2-(2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetamido)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
Tert-butyl 2-((4R,6R)-6-(2-(2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetamido)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
Catalogue No.:PA 01 2410001
CAS :
1116118-82-1
Molecular Formula : C50H64FN3O8
Molecular Weight : 854.07


(3S,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid
(3S,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid
Catalogue No.:PAI 01 006087
CAS :
887324-52-9
Molecular Formula : C33H35FN2O5
Molecular Weight : 558.65


9-Fluoro-2,3-dihydro-3-(1-methylethyl)-2-oxo-N-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-dibenz[e,g]indole-3-carboxamide ;
9-Fluoro-2,3-dihydro-3-(1-methylethyl)-2-oxo-N-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-dibenz[e,g]indole-3-carboxamide
Catalogue No.:PA 01 2410009
CAS :
1795791-15-9
Molecular Formula : C33H31FN2O5
Molecular Weight : 554.62


Ethyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
Ethyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
Catalogue No.:PA 01 2410010
CAS :
616201-27-5
Molecular Formula : C38H43FN2O5
Molecular Weight : 626.77


6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid
6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid
Catalogue No.:PA 01 2410012
CAS :
363599-73-9
Molecular Formula : C36H39FN2O5
Molecular Weight : 598.72


7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-5-hydroxy-3-oxoheptanoic Acid
7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-5-hydroxy-3-oxoheptanoic Acid
Catalogue No.:PA 01 2410014
CAS :
1391194-36-7
Molecular Formula : C33H33FN2O5
Molecular Weight : 556.63