Avapritinib and its Impurities
Avapritinib, sold under the brand name Ayvakit. it is a selective tyrosine kinase inhibitor being investigated for the treatment of multidrug resistant gastrointestinal tumors. Reference standards of Avapritinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
4-(4-(5-(1-(4-Fluorophenyl)vinyl)pyrimidin-2-yl)piperazin-1-yl)-6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazine
4-(4-(5-(1-(4-Fluorophenyl)vinyl)pyrimidin-2-yl)piperazin-1-yl)-6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazine
Catalogue No.:PA 01 3921000
CAS :
1703793-09-2
Molecular Formula : C26H24FN9
Molecular Weight : 481.54
(S)-1-(2-(4-(6-Bromopyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)-1-(4-fluorophenyl)ethan-1-amine
(S)-1-(2-(4-(6-Bromopyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)-1-(4-fluorophenyl)ethan-1-amine
Catalogue No.:PA 01 3921001
CAS :
2505078-30-6
Molecular Formula : C22H22BrFN8
Molecular Weight : 497.38
