Avapritinib and its Impurities
Avapritinib, sold under the brand name Ayvakit. it is a selective tyrosine kinase inhibitor being investigated for the treatment of multidrug resistant gastrointestinal tumors. Reference standards of Avapritinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
4-(4-(5-(1-(4-Fluorophenyl)vinyl)pyrimidin-2-yl)piperazin-1-yl)-6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazine
4-(4-(5-(1-(4-Fluorophenyl)vinyl)pyrimidin-2-yl)piperazin-1-yl)-6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazine
Catalogue No.:PA 01 3921000
CAS :
1703793-09-2
Molecular Formula : C26H24FN9
Molecular Weight : 481.54
(S)-1-(2-(4-(6-Bromopyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)-1-(4-fluorophenyl)ethan-1-amine
(S)-1-(2-(4-(6-Bromopyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)-1-(4-fluorophenyl)ethan-1-amine
Catalogue No.:PA 01 3921001
CAS :
2505078-30-6
Molecular Formula : C22H22BrFN8
Molecular Weight : 497.38
(S)-N-(1-(4-Fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethyl)hydroxylamine
(S)-N-(1-(4-Fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethyl)hydroxylamine
Catalogue No.:PA 01 3921004
CAS :
NA
Molecular Formula : C26H27FN10O
Molecular Weight : 514.57
(2R,3R,4R,5S,6R)-6-((((S)-1-(4-Fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethyl)amino)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid
(2R,3R,4R,5S,6R)-6-((((S)-1-(4-Fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethyl)amino)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid
Catalogue No.:PA 01 3921005
CAS :
NA
Molecular Formula : C32H35FN10O7
Molecular Weight : 690.69
4-(4-(5-(2-(4-Fluorophenyl)propan-2-yl)pyrimidin-2-yl)piperazin-1-yl)-7-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a][1,3,5]triazine
4-(4-(5-(2-(4-Fluorophenyl)propan-2-yl)pyrimidin-2-yl)piperazin-1-yl)-7-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a][1,3,5]triazine
Catalogue No.:PA 01 3921006
CAS :
1703793-31-0
Molecular Formula : C26H27FN10
Molecular Weight : 498.57
(2-(4-(6-(4-Fluorophenyl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)(phenyl)methanone
(2-(4-(6-(4-Fluorophenyl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)(phenyl)methanone
Catalogue No.:PA 01 3921007
CAS :
1703795-41-8
Molecular Formula : C27H22FN7O
Molecular Weight : 479.52
(R)-(4-Fluorophenyl)(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)methanol
(R)-(4-Fluorophenyl)(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)methanol
Catalogue No.:PA 01 3921008
CAS :
1703793-18-3
Molecular Formula : C25H24FN9O
Molecular Weight : 485.53
