Avatrombopag and its Impurities
Avatrombopag, sold under the brand name Doptelet, is a medication that used for certain conditions.lead to thrombocytopenia (low platelets) such as thrombocytopenia associated with chronic liver disease. Reference standards of Avatrombopag API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
Catalogue No.:PA STI 088916
CAS :
NA
Molecular Formula : C29H26D8Cl2N6O3S2
Molecular Weight : 657.7


1-(5-((4-(5-Bromo-4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)-3-chloropyridin-2-yl)piperidine-4-carboxylic Acid
1-(5-((4-(5-Bromo-4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)-3-chloropyridin-2-yl)piperidine-4-carboxylic Acid
Catalogue No.:PA 01 2991001
CAS :
NA
Molecular Formula : C29H33BrCl2N6O3S2
Molecular Weight : 728.55


4-(2-(6-(4-Carboxypiperidin-1-yl)-5-chloronicotinamido)-4-(4-chlorothiophen-2-yl)thiazol-5-yl)-1-cyclohexylpiperazine 1-oxide
4-(2-(6-(4-Carboxypiperidin-1-yl)-5-chloronicotinamido)-4-(4-chlorothiophen-2-yl)thiazol-5-yl)-1-cyclohexylpiperazine 1-oxide
Catalogue No.:PA 01 2991013
CAS :
2681355-40-6
Molecular Formula : C29H34Cl2N6O4S2
Molecular Weight : 665.65


5-Chloro-N-(4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)-6-(dimethylamino)nicotinamide
5-Chloro-N-(4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)-6-(dimethylamino)nicotinamide
Catalogue No.:PA 01 2991008
CAS :
2626934-45-8
Molecular Formula : C25H30Cl2N6OS2
Molecular Weight : 565.58


5,6-Dichloro-N-(4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)nicotinamide
5,6-Dichloro-N-(4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)nicotinamide
Catalogue No.:PA 01 2991012
CAS :
570403-04-2
Molecular Formula : C23H24Cl3N5OS2
Molecular Weight : 556.95


1-(3-Chloro-5-((5-(4-cyclohexylpiperazin-1-yl)-4-(4,5-dichlorothiophen-2-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic Acid
1-(3-Chloro-5-((5-(4-cyclohexylpiperazin-1-yl)-4-(4,5-dichlorothiophen-2-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic Acid
Catalogue No.:PA 01 2991014
CAS :
NA
Molecular Formula : C29H33Cl3N6O3S2
Molecular Weight : 684.09


1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-nitrosopiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic Acid
1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-nitrosopiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic Acid
Catalogue No.:PA 01 2991018
CAS :
NA
Molecular Formula : C23H23Cl2N7O4S2
Molecular Weight : 596.5