axitinib and its Impurities

Axitinib is an indazole derivative. It is most commonly marketed under the name Inlyta® and is available in oral formulations._x000D_ Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3).7. Reference standards of Axitinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

Displaying 55 results for axitinib Impurities
PA 28 45000

Axitinib

Axitinib

  • Catalogue No.:PA 28 45000

  • CAS :

    319460-85-0

  • Molecular Formula : C22H18N4OS

  • Molecular Weight : 386.47

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PA 28 45510

(Z)-Axitinib

(Z)-Axitinib

  • Catalogue No.:PA 28 45510

  • CAS :

    885126-40-9

  • Molecular Formula : C22H18N4OS

  • Molecular Weight : 386.47

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PA 28 45520

2,2'-(1H,1'H-[3,3'-Biindazole]-6,6'-diylbis(sulfanediyl))bis(N-methylbenzamide)

2,2'-(1H,1'H-[3,3'-Biindazole]-6,6'-diylbis(sulfanediyl))bis(N-methylbenzamide)

  • Catalogue No.:PA 28 45520

  • CAS :

    NA

  • Molecular Formula : C30H24N6O2S2

  • Molecular Weight : 564.68

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PA 28 45530

N-Methyl-2-((3-(2-(pyridin-2-yl)ethyl)-1H-indazol-6-yl)thio)benzamide

N-Methyl-2-((3-(2-(pyridin-2-yl)ethyl)-1H-indazol-6-yl)thio)benzamide

  • Catalogue No.:PA 28 45530

  • CAS :

    1443118-73-7

  • Molecular Formula : C22H20N4OS

  • Molecular Weight : 388.49

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PA 28 45540

Axitinib Sulfoxide

Axitinib Sulfoxide

  • Catalogue No.:PA 28 45540

  • CAS :

    1347304-18-0

  • Molecular Formula : C22H18N4O2S

  • Molecular Weight : 402.47

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PA 28 45550

(E)-N-Methyl-2-((1-(2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide

(E)-N-Methyl-2-((1-(2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide

  • Catalogue No.:PA 28 45550

  • CAS :

    1443118-72-6

  • Molecular Formula : C29H25N5OS

  • Molecular Weight : 491.61

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PA 28 45560

Axitinib N-Glucuronide

Axitinib N-Glucuronide

  • Catalogue No.:PA 28 45560

  • CAS :

    NA

  • Molecular Formula : C28H26N4O7S

  • Molecular Weight : 562.59

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PA 28 45570

Axitinib Sulfone Impurity

Axitinib Sulfone Impurity

  • Catalogue No.:PA 28 45570

  • CAS :

    1348536-59-3

  • Molecular Formula : C22H18N4O3S

  • Molecular Weight : 418.47

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PA 28 45580

2-(1H-Indazol-6-ylsulfanyl)-N-methylbenzamide

2-(1H-Indazol-6-ylsulfanyl)-N-methylbenzamide

  • Catalogue No.:PA 28 45580

  • CAS :

    944835-85-2

  • Molecular Formula : C15H13N3OS

  • Molecular Weight : 283.34

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PA 28 45590

2-((3-Iodo-2H-indazol-6-yl)thio)-N-methylbenzamide

2-((3-Iodo-2H-indazol-6-yl)thio)-N-methylbenzamide

  • Catalogue No.:PA 28 45590

  • CAS :

    885126-34-1

  • Molecular Formula : C15H12IN3OS

  • Molecular Weight : 409.24

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PA 28 45600

Dehydro Axitinib

Dehydro Axitinib

  • Catalogue No.:PA 28 45600

  • CAS :

    2749797-54-2

  • Molecular Formula : C22H20N4OS

  • Molecular Weight : 388.49

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PA 28 45610

(E)-2-((3-(2-(Pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzoic Acid

(E)-2-((3-(2-(Pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzoic Acid

  • Catalogue No.:PA 28 45610

  • CAS :

    319462-34-5

  • Molecular Formula : C21H15N3O2S

  • Molecular Weight : 373.43

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PA 28 45620

Axitinib Amide Impurity

Axitinib Amide Impurity

  • Catalogue No.:PA 28 45620

  • CAS :

    319462-41-4

  • Molecular Formula : C21H16N4OS

  • Molecular Weight : 372.44

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PA 28 45630

Axitinib N-Acetyl impurity

Axitinib N-Acetyl impurity

  • Catalogue No.:PA 28 45630

  • CAS :

    1639137-80-6

  • Molecular Formula : C24H20N4O2S

  • Molecular Weight : 428.51

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PA 28 45640

Axitinib N-THP Impurity

Axitinib N-THP Impurity

  • Catalogue No.:PA 28 45640

  • CAS :

    885126-35-2

  • Molecular Formula : C27H26N4O2S

  • Molecular Weight : 470.59

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PA 28 45650

6-Iodo-1H-indazole

6-Iodo-1H-indazole

  • Catalogue No.:PA 28 45650

  • CAS :

    261953-36-0

  • Molecular Formula : C7H5IN2

  • Molecular Weight : 244.03

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PA 28 45660

3,6-Diiodo-1H-indazole

3,6-Diiodo-1H-indazole

  • Catalogue No.:PA 28 45660

  • CAS :

    319472-78-1

  • Molecular Formula : C7H4I2N2

  • Molecular Weight : 369.93

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PA 28 45670

2-((1-Acetyl-1H-indazol-6-yl)sulfinyl)-N-methylbenzamide

2-((1-Acetyl-1H-indazol-6-yl)sulfinyl)-N-methylbenzamide

  • Catalogue No.:PA 28 45670

  • CAS :

    1959572-98-5

  • Molecular Formula : C17H15N3O3S

  • Molecular Weight : 341.38

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PA 28 45680

2-((1H-Indazol-6-yl)sulfinyl)-N-methylbenzamide

2-((1H-Indazol-6-yl)sulfinyl)-N-methylbenzamide

  • Catalogue No.:PA 28 45680

  • CAS :

    1959572-97-4

  • Molecular Formula : C15H13N3O2S

  • Molecular Weight : 299.35

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PA 28 45690

2,2'-(((2,4-di(Pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-3,6-diyl))bis(sulfanediyl))bis(N-methylbenzamide)

2,2'-(((2,4-di(Pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-3,6-diyl))bis(sulfanediyl))bis(N-methylbenzamide)

  • Catalogue No.:PA 28 45690

  • CAS :

    1428728-83-9

  • Molecular Formula : C44H36N8O2S2

  • Molecular Weight : 772.94

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PA 28 45700

2-((3-Iodo-1H-indazol-6-yl)sulfinyl)-N-methylbenzamide

2-((3-Iodo-1H-indazol-6-yl)sulfinyl)-N-methylbenzamide

  • Catalogue No.:PA 28 45700

  • CAS :

    1443118-71-5

  • Molecular Formula : C15H12IN3O2S

  • Molecular Weight : 425.24

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PA STI 009300

Axitinib-d3

Axitinib-d3

  • Catalogue No.:PA STI 009300

  • CAS :

    1126623-89-9

  • Molecular Formula : C22H15D3N4OS

  • Molecular Weight : 389.49

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PA STI 009301

Axitinib-13C-d3

Axitinib-13C-d3

  • Catalogue No.:PA STI 009301

  • CAS :

    1261432-00-1

  • Molecular Formula : C2113CH15D3N4OS

  • Molecular Weight : 390.48

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PAI 01 013010

3,6-Diiodo-1H-indazole

3,6-Diiodo-1H-indazole

  • Catalogue No.:PAI 01 013010

  • CAS :

    319472-78-1

  • Molecular Formula : C7H4I2N2

  • Molecular Weight : 369.93

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PAI 01 013020

(E)-2-((1-acetyl-3-styryl-1H-indazol-6-yl)thio)-N-methylbenzamide

(E)-2-((1-acetyl-3-styryl-1H-indazol-6-yl)thio)-N-methylbenzamide

  • Catalogue No.:PAI 01 013020

  • CAS :

    NA

  • Molecular Formula : C25H21N3O2S

  • Molecular Weight : 427.52

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PAI 01 013030

2-((1-Acetyl-1H-indazol-6-yl)thio)-N-methylbenzamide

2-((1-Acetyl-1H-indazol-6-yl)thio)-N-methylbenzamide

  • Catalogue No.:PAI 01 013030

  • CAS :

    NA

  • Molecular Formula : C17H15N3O2S

  • Molecular Weight : 325.39

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PA 28 45720

2,2'-Dithiobis[N-methyl-benzamide]

2,2'-Dithiobis[N-methyl-benzamide]

  • Catalogue No.:PA 28 45720

  • CAS :

    2527-58-4

  • Molecular Formula : C16H16N2O2S2

  • Molecular Weight : 332.44

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PA 28 45730

N-Methyl-2-sulfanylbenzamide

N-Methyl-2-sulfanylbenzamide

  • Catalogue No.:PA 28 45730

  • CAS :

    20054-45-9

  • Molecular Formula : C8H9NOS

  • Molecular Weight : 167.23

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PA 28 45740

(E)-2-(2-(6-((2-(Methylcarbamoyl)phenyl)thio)-1H-indazol-3-yl)vinyl)pyridine 1-oxide

(E)-2-(2-(6-((2-(Methylcarbamoyl)phenyl)thio)-1H-indazol-3-yl)vinyl)pyridine 1-oxide

  • Catalogue No.:PA 28 45740

  • CAS :

    NA

  • Molecular Formula : C22H18N4O2S

  • Molecular Weight : 402.47

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PA 28 45750

N-​Methyl-​2-​[[3-​[(1E)​-​2-​(1-​oxido-​2-​pyridinyl)​ethenyl]​-​1H-​indazol-​6-​yl]​sulfinyl]​-benzamide

N-​Methyl-​2-​[[3-​[(1E)​-​2-​(1-​oxido-​2-​pyridinyl)​ethenyl]​-​1H-​indazol-​6-​yl]​sulfinyl]​-benzamide

  • Catalogue No.:PA 28 45750

  • CAS :

    1348044-24-5

  • Molecular Formula : C22H18N4O3S

  • Molecular Weight : 418.47

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PA 28 45760

(E)-2-(2-(6-((2-(Methylcarbamoyl)phenyl)sulfonyl)-1H-indazol-3-yl)vinyl)pyridine 1-oxide

(E)-2-(2-(6-((2-(Methylcarbamoyl)phenyl)sulfonyl)-1H-indazol-3-yl)vinyl)pyridine 1-oxide

  • Catalogue No.:PA 28 45760

  • CAS :

    NA

  • Molecular Formula : C22H18N4O4S

  • Molecular Weight : 434.47

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PA 28 0451000

(Z)-N-Methyl-2-((1-(1-(6-((2-(methylcarbamoyl)phenyl)thio)-1H-indazol-3-yl)-2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide

(Z)-N-Methyl-2-((1-(1-(6-((2-(methylcarbamoyl)phenyl)thio)-1H-indazol-3-yl)-2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide

  • Catalogue No.:PA 28 0451000

  • CAS :

    1428728-84-0

  • Molecular Formula : C44H36N8O2S2

  • Molecular Weight : 772.95

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PA 28 45710

Axitinib N-Acetyl Sulfone Impurity

Axitinib N-Acetyl Sulfone Impurity

  • Catalogue No.:PA 28 45710

  • CAS :

    NA

  • Molecular Formula : C24H20N4O3S

  • Molecular Weight : 444.51

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PA 28 0451002

(E)-6-Iodo-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

(E)-6-Iodo-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

  • Catalogue No.:PA 28 0451002

  • CAS :

    886230-77-9

  • Molecular Formula : C19H18IN3O

  • Molecular Weight : 431.28

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PA 28 0451003

3-Iodo-6-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

3-Iodo-6-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

  • Catalogue No.:PA 28 0451003

  • CAS :

    886230-74-6

  • Molecular Formula : C12H12IN3O3

  • Molecular Weight : 373.15

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PA 28 0451004

(E)-6-((2-(Methylcarbamoyl)phenyl)sulfonyl)-3-(2-(1-oxidopyridin-2-yl)vinyl)-1H-indazole 1-oxide

(E)-6-((2-(Methylcarbamoyl)phenyl)sulfonyl)-3-(2-(1-oxidopyridin-2-yl)vinyl)-1H-indazole 1-oxide

  • Catalogue No.:PA 28 0451004

  • CAS :

    NA

  • Molecular Formula : C22H18N4O5S

  • Molecular Weight : 450.47

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PA 28 0451005

N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1-formyl-indazol-6-yl]sulfanyl]-benzamide

N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1-formyl-indazol-6-yl]sulfanyl]-benzamide

  • Catalogue No.:PA 28 0451005

  • CAS :

    NA

  • Molecular Formula : C23H18N4O2S

  • Molecular Weight : 414.48

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PA 28 0451006

N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1-hydroxymethyl-indazol-6-yl]sulfanyl]-benzamide

N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1-hydroxymethyl-indazol-6-yl]sulfanyl]-benzamide

  • Catalogue No.:PA 28 0451006

  • CAS :

    2607948-75-2

  • Molecular Formula : C23H20N4O2S

  • Molecular Weight : 416.5

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PA 28 0451007

 N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1-methyl-indazol-6-yl]sulfanyl]-benzamide

N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1-methyl-indazol-6-yl]sulfanyl]-benzamide

  • Catalogue No.:PA 28 0451007

  • CAS :

    NA

  • Molecular Formula : C23H20N4OS

  • Molecular Weight : 400.5

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PA 28 0451008

Axitinib des Iodo analog

Axitinib des Iodo analog

  • Catalogue No.:PA 28 0451008

  • CAS :

    2242852-05-5

  • Molecular Formula : C19H19N3O

  • Molecular Weight : 305.38

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PA 28 0451011

Axitinib galactose adduct

Axitinib galactose adduct

  • Catalogue No.:PA 28 0451011

  • CAS :

    NA

  • Molecular Formula : C28H28N4O6S

  • Molecular Weight : 548.61

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PA 28 0451012

(E)-3-(2-(Pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-amine

(E)-3-(2-(Pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-amine

  • Catalogue No.:PA 28 0451012

  • CAS :

    886230-76-8

  • Molecular Formula : C19H20N4O

  • Molecular Weight : 320.4

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PA 28 0451013

6-Iodo-3-[2-(pyridin- 2yl)ethyl]-1-(tetrahydro-2H-pyran- 2-yl)-1H-indazole

6-Iodo-3-[2-(pyridin- 2yl)ethyl]-1-(tetrahydro-2H-pyran- 2-yl)-1H-indazole

  • Catalogue No.:PA 28 0451013

  • CAS :

    NA

  • Molecular Formula : C19H20IN3O

  • Molecular Weight : 433.29

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PA 28 0451014

3-Lodo-6-nitro-1(tetra hydro-2H-pyran-2-yl)-1H-indazole

3-Lodo-6-nitro-1(tetra hydro-2H-pyran-2-yl)-1H-indazole

  • Catalogue No.:PA 28 0451014

  • CAS :

     886230-74-6

  • Molecular Formula : C12H12IN3O3

  • Molecular Weight : 373.15

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PA 28 0451015

(E)-2-((1-Hydroxy-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)-N-methylbenzamide

(E)-2-((1-Hydroxy-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)-N-methylbenzamide

  • Catalogue No.:PA 28 0451015

  • CAS :

    NA

  • Molecular Formula : C22H18N4O2S

  • Molecular Weight : 402.47

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PA 28 0451016

2-((1-((3R,4R,5S,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)-3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)-N-methylbenzamide

2-((1-((3R,4R,5S,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)-3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)-N-methylbenzamide

  • Catalogue No.:PA 28 0451016

  • CAS :

    NA

  • Molecular Formula : C34H38N4O11S

  • Molecular Weight : 710.76

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PA 28 0451017

(E)-2-((1-Formyl-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)-N-methylbenzamide

(E)-2-((1-Formyl-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)-N-methylbenzamide

  • Catalogue No.:PA 28 0451017

  • CAS :

    NA

  • Molecular Formula : C23H18N4O2S

  • Molecular Weight : 414.48

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PA 28 0451018

N-(2-((Hydroxy(2-((3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)phenyl)methyl)amino)ethyl)-2-((3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide

N-(2-((Hydroxy(2-((3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)phenyl)methyl)amino)ethyl)-2-((3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide

  • Catalogue No.:PA 28 0451018

  • CAS :

    NA

  • Molecular Formula : C44H36N8O2S2

  • Molecular Weight : 772.95

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PA 28 0451019

N-Nitroso Axitinib

N-Nitroso Axitinib

  • Catalogue No.:PA 28 0451019

  • CAS :

    NA

  • Molecular Formula : C22H17N5O2S

  • Molecular Weight : 415.47

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PA 28 0451020

2-[(2-Carbamoylphenyl)disulfanyl]benzamide

2-[(2-Carbamoylphenyl)disulfanyl]benzamide

  • Catalogue No.:PA 28 0451020

  • CAS :

    2527-57-3

  • Molecular Formula : C14H12N2O2S2

  • Molecular Weight : 304.38

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PA 28 0451021

6-Iodo-1-nitroso-1H-indazole

6-Iodo-1-nitroso-1H-indazole

  • Catalogue No.:PA 28 0451021

  • CAS :

    NA

  • Molecular Formula : C7H4IN3O

  • Molecular Weight : 273.03

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PA 28 0451022

N-Methyl-2-((1-nitroso-1H-indazol-6-yl)thio)benzamide

N-Methyl-2-((1-nitroso-1H-indazol-6-yl)thio)benzamide

  • Catalogue No.:PA 28 0451022

  • CAS :

    NA

  • Molecular Formula : C15H12N4O2S

  • Molecular Weight : 312.35

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PA 28 0451023

2-((3-Iodo-1-nitroso-1H-indazol-6-yl)thio)-N-methylbenzamide

2-((3-Iodo-1-nitroso-1H-indazol-6-yl)thio)-N-methylbenzamide

  • Catalogue No.:PA 28 0451023

  • CAS :

    NA

  • Molecular Formula : C15H11IN4O2S

  • Molecular Weight : 438.24

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PA 28 0451024

(E)-6-Nitro-3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

(E)-6-Nitro-3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

  • Catalogue No.:PA 28 0451024

  • CAS :

    886230-75-7

  • Molecular Formula : C19H18N4O3

  • Molecular Weight : 350.38

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PA 28 0451001

N-(2-((hydroxy(2-((3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)phenyl)methyl)amino)ethyl)-2-((3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide

N-(2-((hydroxy(2-((3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)phenyl)methyl)amino)ethyl)-2-((3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide

  • Catalogue No.:PA 28 0451001

  • CAS :

    NA

  • Molecular Formula : C44H36N8O2S2

  • Molecular Weight : 772.95

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