Axitinib is an indazole derivative. It is most commonly marketed under the name Inlyta® and is available in oral formulations._x000D_ Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3).7. Reference standards of Axitinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Axitinib
Catalogue No.:PA 28 45000
CAS :
Molecular Formula : C22H18N4OS
Molecular Weight : 386.47
(Z)-Axitinib
Catalogue No.:PA 28 45510
2,2'-(1H,1'H-[3,3'-Biindazole]-6,6'-diylbis(sulfanediyl))bis(N-methylbenzamide)
Catalogue No.:PA 28 45520
Molecular Formula : C30H24N6O2S2
Molecular Weight : 564.68
N-Methyl-2-((3-(2-(pyridin-2-yl)ethyl)-1H-indazol-6-yl)thio)benzamide
Catalogue No.:PA 28 45530
Molecular Formula : C22H20N4OS
Molecular Weight : 388.49
Axitinib Sulfoxide
Catalogue No.:PA 28 45540
Molecular Formula : C22H18N4O2S
Molecular Weight : 402.47
(E)-N-Methyl-2-((1-(2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide
Catalogue No.:PA 28 45550
Molecular Formula : C29H25N5OS
Molecular Weight : 491.61
Axitinib N-Glucuronide
Catalogue No.:PA 28 45560
Molecular Formula : C28H26N4O7S
Molecular Weight : 562.59
Axitinib Sulfone Impurity
Catalogue No.:PA 28 45570
Molecular Formula : C22H18N4O3S
Molecular Weight : 418.47
2-(1H-Indazol-6-ylsulfanyl)-N-methylbenzamide
Catalogue No.:PA 28 45580
Molecular Formula : C15H13N3OS
Molecular Weight : 283.34
2-((3-Iodo-2H-indazol-6-yl)thio)-N-methylbenzamide
Catalogue No.:PA 28 45590
Molecular Formula : C15H12IN3OS
Molecular Weight : 409.24
Dehydro Axitinib
Catalogue No.:PA 28 45600
(E)-2-((3-(2-(Pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzoic Acid
Catalogue No.:PA 28 45610
Molecular Formula : C21H15N3O2S
Molecular Weight : 373.43
Axitinib Amide Impurity
Catalogue No.:PA 28 45620
Molecular Formula : C21H16N4OS
Molecular Weight : 372.44
Axitinib N-Acetyl impurity
Catalogue No.:PA 28 45630
Molecular Formula : C24H20N4O2S
Molecular Weight : 428.51
Axitinib N-THP Impurity
Catalogue No.:PA 28 45640
Molecular Formula : C27H26N4O2S
Molecular Weight : 470.59
6-Iodo-1H-indazole
Catalogue No.:PA 28 45650
Molecular Formula : C7H5IN2
Molecular Weight : 244.03
3,6-Diiodo-1H-indazole
Catalogue No.:PA 28 45660
Molecular Formula : C7H4I2N2
Molecular Weight : 369.93
2-((1-Acetyl-1H-indazol-6-yl)sulfinyl)-N-methylbenzamide
Catalogue No.:PA 28 45670
Molecular Formula : C17H15N3O3S
Molecular Weight : 341.38
2-((1H-Indazol-6-yl)sulfinyl)-N-methylbenzamide
Catalogue No.:PA 28 45680
Molecular Formula : C15H13N3O2S
Molecular Weight : 299.35
2,2'-(((2,4-di(Pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-3,6-diyl))bis(sulfanediyl))bis(N-methylbenzamide)
Catalogue No.:PA 28 45690
Molecular Formula : C44H36N8O2S2
Molecular Weight : 772.94
2-((3-Iodo-1H-indazol-6-yl)sulfinyl)-N-methylbenzamide
Catalogue No.:PA 28 45700
Molecular Formula : C15H12IN3O2S
Molecular Weight : 425.24
Axitinib-d3
Catalogue No.:PA STI 009300
Molecular Formula : C22H15D3N4OS
Molecular Weight : 389.49
Axitinib-13C-d3
Catalogue No.:PA STI 009301
Molecular Formula : C2113CH15D3N4OS
Molecular Weight : 390.48
Catalogue No.:PAI 01 013010
(E)-2-((1-acetyl-3-styryl-1H-indazol-6-yl)thio)-N-methylbenzamide
Catalogue No.:PAI 01 013020
Molecular Formula : C25H21N3O2S
Molecular Weight : 427.52
2-((1-Acetyl-1H-indazol-6-yl)thio)-N-methylbenzamide
Catalogue No.:PAI 01 013030
Molecular Formula : C17H15N3O2S
Molecular Weight : 325.39
2,2'-Dithiobis[N-methyl-benzamide]
Catalogue No.:PA 28 45720
Molecular Formula : C16H16N2O2S2
Molecular Weight : 332.44
N-Methyl-2-sulfanylbenzamide
Catalogue No.:PA 28 45730
Molecular Formula : C8H9NOS
Molecular Weight : 167.23
(E)-2-(2-(6-((2-(Methylcarbamoyl)phenyl)thio)-1H-indazol-3-yl)vinyl)pyridine 1-oxide
Catalogue No.:PA 28 45740
N-Methyl-2-[[3-[(1E)-2-(1-oxido-2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide
Catalogue No.:PA 28 45750
(E)-2-(2-(6-((2-(Methylcarbamoyl)phenyl)sulfonyl)-1H-indazol-3-yl)vinyl)pyridine 1-oxide
Catalogue No.:PA 28 45760
Molecular Formula : C22H18N4O4S
Molecular Weight : 434.47
(Z)-N-Methyl-2-((1-(1-(6-((2-(methylcarbamoyl)phenyl)thio)-1H-indazol-3-yl)-2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide
Catalogue No.:PA 28 0451000
Molecular Weight : 772.95
Axitinib N-Acetyl Sulfone Impurity
Catalogue No.:PA 28 45710
Molecular Formula : C24H20N4O3S
Molecular Weight : 444.51
(E)-6-Iodo-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
Catalogue No.:PA 28 0451002
Molecular Formula : C19H18IN3O
Molecular Weight : 431.28
3-Iodo-6-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
Catalogue No.:PA 28 0451003
Molecular Formula : C12H12IN3O3
Molecular Weight : 373.15
(E)-6-((2-(Methylcarbamoyl)phenyl)sulfonyl)-3-(2-(1-oxidopyridin-2-yl)vinyl)-1H-indazole 1-oxide
Catalogue No.:PA 28 0451004
Molecular Formula : C22H18N4O5S
Molecular Weight : 450.47
N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1-formyl-indazol-6-yl]sulfanyl]-benzamide
Catalogue No.:PA 28 0451005
Molecular Formula : C23H18N4O2S
Molecular Weight : 414.48
N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1-hydroxymethyl-indazol-6-yl]sulfanyl]-benzamide
Catalogue No.:PA 28 0451006
Molecular Formula : C23H20N4O2S
Molecular Weight : 416.5
N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1-methyl-indazol-6-yl]sulfanyl]-benzamide
Catalogue No.:PA 28 0451007
Molecular Formula : C23H20N4OS
Molecular Weight : 400.5
Axitinib des Iodo analog
Catalogue No.:PA 28 0451008
Molecular Formula : C19H19N3O
Molecular Weight : 305.38
Axitinib galactose adduct
Catalogue No.:PA 28 0451011
Molecular Formula : C28H28N4O6S
Molecular Weight : 548.61
(E)-3-(2-(Pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-amine
Catalogue No.:PA 28 0451012
Molecular Formula : C19H20N4O
Molecular Weight : 320.4
6-Iodo-3-[2-(pyridin- 2yl)ethyl]-1-(tetrahydro-2H-pyran- 2-yl)-1H-indazole
Catalogue No.:PA 28 0451013
Molecular Formula : C19H20IN3O
Molecular Weight : 433.29
3-Lodo-6-nitro-1(tetra hydro-2H-pyran-2-yl)-1H-indazole
Catalogue No.:PA 28 0451014
(E)-2-((1-Hydroxy-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)-N-methylbenzamide
Catalogue No.:PA 28 0451015
2-((1-((3R,4R,5S,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)-3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)-N-methylbenzamide
Catalogue No.:PA 28 0451016
Molecular Formula : C34H38N4O11S
Molecular Weight : 710.76
(E)-2-((1-Formyl-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)-N-methylbenzamide
Catalogue No.:PA 28 0451017
N-(2-((Hydroxy(2-((3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)phenyl)methyl)amino)ethyl)-2-((3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide
Catalogue No.:PA 28 0451018
N-Nitroso Axitinib
Catalogue No.:PA 28 0451019
Molecular Formula : C22H17N5O2S
Molecular Weight : 415.47
2-[(2-Carbamoylphenyl)disulfanyl]benzamide
Catalogue No.:PA 28 0451020
Molecular Formula : C14H12N2O2S2
Molecular Weight : 304.38
6-Iodo-1-nitroso-1H-indazole
Catalogue No.:PA 28 0451021
Molecular Formula : C7H4IN3O
Molecular Weight : 273.03
N-Methyl-2-((1-nitroso-1H-indazol-6-yl)thio)benzamide
Catalogue No.:PA 28 0451022
Molecular Formula : C15H12N4O2S
Molecular Weight : 312.35
2-((3-Iodo-1-nitroso-1H-indazol-6-yl)thio)-N-methylbenzamide
Catalogue No.:PA 28 0451023
Molecular Formula : C15H11IN4O2S
Molecular Weight : 438.24
(E)-6-Nitro-3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
Catalogue No.:PA 28 0451024
Molecular Formula : C19H18N4O3
Molecular Weight : 350.38
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