Baricitinib-Impurities | Pharmaffiliates

baricitinib and its Impurities

Baricitinib was approved in February of 2017 as a second-line orally administered treatment for moderate to severe active rheumatoid arthritis in adults, either as a monotherapy or when combined with methotrexate.Baricitinib is a selective and reversible Janus kinase 1 (JAK1) and 2 (JAK2) inhibitor. Janus kinases belong to the tyrosine protein kinase family and play an important role in the proinflammatory pathway signalling that is frequently over-activated in autoimmune disorders such as rheumatoid arthritis. Reference standards of Baricitinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

Displaying 11 results for baricitinib Impurities
PA 29 41000

Baricitinib - API

Baricitinib


  • Catalogue No.:PA 29 41000

  • CAS :

    1187594-09-7

  • Molecular Formula : C16H17N7O2S

  • Molecular Weight : 371.42

PA 29 0411000

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetamide

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetamide


  • Catalogue No.:PA 29 0411000

  • CAS :

    2271228-51-2

  • Molecular Formula : C16H19N7O3S

  • Molecular Weight : 389.43

PA 29 0411001

2-(1-(Ethylsulfonyl)-3-(4-(7-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

2-(1-(Ethylsulfonyl)-3-(4-(7-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile


  • Catalogue No.:PA 29 0411001

  • CAS :

    1187595-89-6

  • Molecular Formula : C17H19N7O3S

  • Molecular Weight : 401.45

PA 29 0411002

2-(1-(Ethylsulfonyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

2-(1-(Ethylsulfonyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile


  • Catalogue No.:PA 29 0411002

  • CAS :

    1187594-13-3

  • Molecular Formula : C22H31N7O3SSi

  • Molecular Weight : 501.68

PA 29 0411003

N-((3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-5-oxotetrahydrofuran-3-yl)methyl)ethanesulfonamide

N-((3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-5-oxotetrahydrofuran-3-yl)methyl)ethanesulfonamide


  • Catalogue No.:PA 29 0411003

  • CAS :

    NA

  • Molecular Formula : C16H18N6O4S

  • Molecular Weight : 390.42

PA 29 0411004

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetic acid

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetic acid


  • Catalogue No.:PA 29 0411004

  • CAS :

    2271228-52-3

  • Molecular Formula : C16H18N6O4S

  • Molecular Weight : 390.42

PA 29 0411005

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(propylsulfonyl)azetidin-3-yl)acetonitrile

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(propylsulfonyl)azetidin-3-yl)acetonitrile


  • Catalogue No.:PA 29 0411005

  • CAS :

    1187594-34-8

  • Molecular Formula : C17H19N7O2S

  • Molecular Weight : 385.45

PA 29 0411006

Tert-butyl 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-(cyanomethyl)azetidine-1-carboxylate

Tert-butyl 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-(cyanomethyl)azetidine-1-carboxylate


  • Catalogue No.:PA 29 0411006

  • CAS :

    1627504-41-9

  • Molecular Formula : C19H21N7O2

  • Molecular Weight : 379.42

PA 29 0411007

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile Dihydrochloride

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile Dihydrochloride


  • Catalogue No.:PA 29 0411007

  • CAS :

    1627504-43-1

  • Molecular Formula : C14H15Cl2N7

  • Molecular Weight : 352.22

PA 29 0411008

Methyl 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetate

Methyl 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetate


  • Catalogue No.:PA 29 0411008

  • CAS :

    2402776-80-9

  • Molecular Formula : C17H20N6O4S

  • Molecular Weight : 404.45

PA 29 0411009

2-(1-(Ethylsulfonyl)-3-(4-(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

2-(1-(Ethylsulfonyl)-3-(4-(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile


  • Catalogue No.:PA 29 0411009

  • CAS :

    NA

  • Molecular Formula : C16H16N8O3S

  • Molecular Weight : 400.42