baricitinib and its Impurities

Baricitinib was approved in February of 2017 as a second-line orally administered treatment for moderate to severe active rheumatoid arthritis in adults, either as a monotherapy or when combined with methotrexate.Baricitinib is a selective and reversible Janus kinase 1 (JAK1) and 2 (JAK2) inhibitor. Janus kinases belong to the tyrosine protein kinase family and play an important role in the proinflammatory pathway signalling that is frequently over-activated in autoimmune disorders such as rheumatoid arthritis. Reference standards of Baricitinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

Displaying 38 results for baricitinib Impurities
Drug Reference Standards & Impurity Synthesis in India
PA 29 41000

Baricitinib

Baricitinib

  • Catalogue No.:PA 29 41000

  • CAS :

    1187594-09-7

  • Molecular Formula : C16H17N7O2S

  • Molecular Weight : 371.42

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411000

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetamide

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetamide

  • Catalogue No.:PA 29 0411000

  • CAS :

    2271228-51-2

  • Molecular Formula : C16H19N7O3S

  • Molecular Weight : 389.43

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411001

2-(1-(Ethylsulfonyl)-3-(4-(7-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

2-(1-(Ethylsulfonyl)-3-(4-(7-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

  • Catalogue No.:PA 29 0411001

  • CAS :

    1187595-89-6

  • Molecular Formula : C17H19N7O3S

  • Molecular Weight : 401.45

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411002

2-(1-(Ethylsulfonyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

2-(1-(Ethylsulfonyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

  • Catalogue No.:PA 29 0411002

  • CAS :

    1187594-13-3

  • Molecular Formula : C22H31N7O3SSi

  • Molecular Weight : 501.68

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411003

N-((3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-5-oxotetrahydrofuran-3-yl)methyl)ethanesulfonamide

N-((3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-5-oxotetrahydrofuran-3-yl)methyl)ethanesulfonamide

  • Catalogue No.:PA 29 0411003

  • CAS :

    2910813-43-1

  • Molecular Formula : C16H18N6O4S

  • Molecular Weight : 390.42

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411004

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetic acid

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetic acid

  • Catalogue No.:PA 29 0411004

  • CAS :

    2271228-52-3

  • Molecular Formula : C16H18N6O4S

  • Molecular Weight : 390.42

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411005

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(propylsulfonyl)azetidin-3-yl)acetonitrile

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(propylsulfonyl)azetidin-3-yl)acetonitrile

  • Catalogue No.:PA 29 0411005

  • CAS :

    1187594-34-8

  • Molecular Formula : C17H19N7O2S

  • Molecular Weight : 385.45

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411006

Tert-butyl 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-(cyanomethyl)azetidine-1-carboxylate

Tert-butyl 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-(cyanomethyl)azetidine-1-carboxylate

  • Catalogue No.:PA 29 0411006

  • CAS :

    1627504-41-9

  • Molecular Formula : C19H21N7O2

  • Molecular Weight : 379.42

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411007

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile Dihydrochloride

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile Dihydrochloride

  • Catalogue No.:PA 29 0411007

  • CAS :

    1627504-43-1

  • Molecular Formula : C14H15Cl2N7

  • Molecular Weight : 352.22

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411008

Methyl 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetate

Methyl 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetate

  • Catalogue No.:PA 29 0411008

  • CAS :

    2402776-80-9

  • Molecular Formula : C17H20N6O4S

  • Molecular Weight : 404.45

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411009

2-(1-(Ethylsulfonyl)-3-(4-(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

2-(1-(Ethylsulfonyl)-3-(4-(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

  • Catalogue No.:PA 29 0411009

  • CAS :

    NA

  • Molecular Formula : C16H16N8O3S

  • Molecular Weight : 400.42

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411010

2-(1-(Ethylsulfonyl)-3-(1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

2-(1-(Ethylsulfonyl)-3-(1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

  • Catalogue No.:PA 29 0411010

  • CAS :

    NA

  • Molecular Formula : C10H14N4O2S

  • Molecular Weight : 254.31

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411011

2-(3-(4-(7H-[4,7'-Bipyrrolo[2,3-d]pyrimidin]-4'-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile

2-(3-(4-(7H-[4,7'-Bipyrrolo[2,3-d]pyrimidin]-4'-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile

  • Catalogue No.:PA 29 0411011

  • CAS :

    2910813-45-3

  • Molecular Formula : C22H20N10O2S

  • Molecular Weight : 488.53

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411012

2,2'-(1H,1'H-[4,4'-Bipyrazole]-1,1'-diylbis(1-(ethylsulfonyl)azetidine-3,3-diyl))diacetonitrile

2,2'-(1H,1'H-[4,4'-Bipyrazole]-1,1'-diylbis(1-(ethylsulfonyl)azetidine-3,3-diyl))diacetonitrile

  • Catalogue No.:PA 29 0411012

  • CAS :

    NA

  • Molecular Formula : C20H26N8O4S2

  • Molecular Weight : 506.6

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411013

2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile

2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile

  • Catalogue No.:PA 29 0411013

  • CAS :

    1187595-85-2

  • Molecular Formula : C7H10N2O2S

  • Molecular Weight : 186.23

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411014

Tert-butyl 4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylate

Tert-butyl 4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylate

  • Catalogue No.:PA 29 0411014

  • CAS :

    2055723-13-0

  • Molecular Formula : C21H25N7O4S

  • Molecular Weight : 471.54

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411015

4-Chloro-7-nitroso-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7-nitroso-7H-pyrrolo[2,3-d]pyrimidine

  • Catalogue No.:PA 29 0411015

  • CAS :

    NA

  • Molecular Formula : C6H3ClN4O

  • Molecular Weight : 182.57

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411016

4-Bromo-1-nitroso-1H-pyrazole

4-Bromo-1-nitroso-1H-pyrazole

  • Catalogue No.:PA 29 0411016

  • CAS :

    NA

  • Molecular Formula : C3H2BrN3O

  • Molecular Weight : 175.97

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411017

1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

  • Catalogue No.:PA 29 0411017

  • CAS :

    1029716-44-6

  • Molecular Formula : C13H23BN2O3

  • Molecular Weight : 266.15

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411018

tert-Butyl 3-(cyanomethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate

tert-Butyl 3-(cyanomethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate

  • Catalogue No.:PA 29 0411018

  • CAS :

    1153949-15-5

  • Molecular Formula : C19H29BN4O4

  • Molecular Weight : 388.28

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411019

(4-(1-(3-(Cyanomethyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl Pivalate

(4-(1-(3-(Cyanomethyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl Pivalate

  • Catalogue No.:PA 29 0411019

  • CAS :

    2102104-38-9

  • Molecular Formula : C20H23N7O2

  • Molecular Weight : 393.45

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411020

(4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl Pivalate

(4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl Pivalate

  • Catalogue No.:PA 29 0411020

  • CAS :

    1187595-90-9

  • Molecular Formula : C22H27N7O4S

  • Molecular Weight : 485.56

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411021

1-Boc-3-(cyanomethylene)azetidine

1-Boc-3-(cyanomethylene)azetidine

  • Catalogue No.:PA 29 0411021

  • CAS :

    1153949-11-1

  • Molecular Formula : C10H14N2O2

  • Molecular Weight : 194.23

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411022

2-(3-(4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile

2-(3-(4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile

  • Catalogue No.:PA 29 0411022

  • CAS :

    2402776-84-3

  • Molecular Formula : C23H27N9O4S2

  • Molecular Weight : 557.65

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411023

tert-Butyl 3-(cyanomethyl)-3-(4-(7-((pivaloyloxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate

tert-Butyl 3-(cyanomethyl)-3-(4-(7-((pivaloyloxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate

  • Catalogue No.:PA 29 0411023

  • CAS :

    2102104-37-8

  • Molecular Formula : C25H31N7O4

  • Molecular Weight : 493.57

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411024

4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

  • Catalogue No.:PA 29 0411024

  • CAS :

    941685-26-3

  • Molecular Formula : C12H18ClN3OSi

  • Molecular Weight : 283.83

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411025

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-nitrosoazetidin-3-yl)acetonitrile

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-nitrosoazetidin-3-yl)acetonitrile

  • Catalogue No.:PA 29 0411025

  • CAS :

    NA

  • Molecular Formula : C14H12N8O

  • Molecular Weight : 308.31

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411026

(1-(1-Ethoxyethyl)-1H-pyrazol-4-yl)boronic Acid

(1-(1-Ethoxyethyl)-1H-pyrazol-4-yl)boronic Acid

  • Catalogue No.:PA 29 0411026

  • CAS :

    2227194-01-4

  • Molecular Formula : C7H13BN2O3

  • Molecular Weight : 184

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411027

tert-Butyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylate

tert-Butyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylate

  • Catalogue No.:PA 29 0411027

  • CAS :

    1236033-21-8

  • Molecular Formula : C11H12ClN3O2

  • Molecular Weight : 253.69

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411028

4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)pyrimidine-5-carbonitrile

4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)pyrimidine-5-carbonitrile

  • Catalogue No.:PA 29 0411028

  • CAS :

    2964606-44-6

  • Molecular Formula : C15H15N7O2S

  • Molecular Weight : 357.39

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411029

2-(1-(Ethylsulfonyl)-3-(4-(5-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

2-(1-(Ethylsulfonyl)-3-(4-(5-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

  • Catalogue No.:PA 29 0411029

  • CAS :

    NA

  • Molecular Formula : C17H19N7O3S

  • Molecular Weight : 401.45

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411030

2-(3-(4-(7-Nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(propylsulfonyl)azetidin-3-yl)acetonitrile

2-(3-(4-(7-Nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(propylsulfonyl)azetidin-3-yl)acetonitrile

  • Catalogue No.:PA 29 0411030

  • CAS :

    NA

  • Molecular Formula : C17H18N8O3S

  • Molecular Weight : 414.44

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411031

tert-Butyl 2-chloro-5H-pyrrolo[3,2-d]pyrimidine-5-carboxylate

tert-Butyl 2-chloro-5H-pyrrolo[3,2-d]pyrimidine-5-carboxylate

  • Catalogue No.:PA 29 0411031

  • CAS :

    1936241-06-3

  • Molecular Formula : C11H12ClN3O2

  • Molecular Weight : 253.69

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411032

tert-Butyl 2-chloro-7,8-dihydropyrido[3,2-d]pyrimidine-5(6H)-carboxylate

tert-Butyl 2-chloro-7,8-dihydropyrido[3,2-d]pyrimidine-5(6H)-carboxylate

  • Catalogue No.:PA 29 0411032

  • CAS :

    1421311-91-2

  • Molecular Formula : C12H16ClN3O2

  • Molecular Weight : 269.73

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411033

4-(1H-Pyrazol-4-yl)-7-(((2-(trimethylsilyl)ethoxy)methoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

4-(1H-Pyrazol-4-yl)-7-(((2-(trimethylsilyl)ethoxy)methoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

  • Catalogue No.:PA 29 0411033

  • CAS :

    NA

  • Molecular Formula : C16H23N5O2Si

  • Molecular Weight : 345.48

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411034

2-Chloro-7H-pyrrolo[2,3-d]pyrimidine

2-Chloro-7H-pyrrolo[2,3-d]pyrimidine

  • Catalogue No.:PA 29 0411034

  • CAS :

    335654-06-3

  • Molecular Formula : C6H4ClN3

  • Molecular Weight : 153.57

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411035

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(butylsulfonyl)azetidin-3-yl)acetonitrile

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(butylsulfonyl)azetidin-3-yl)acetonitrile

  • Catalogue No.:PA 29 0411035

  • CAS :

    1187594-35-9

  • Molecular Formula : C18H21N7O2S

  • Molecular Weight : 399.47

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Drug Reference Standards & Impurity Synthesis in India
PA 29 0411036

Methyl 7H-pyrrolo[2,3-d]pyrimidine-4-carboxylate

Methyl 7H-pyrrolo[2,3-d]pyrimidine-4-carboxylate

  • Catalogue No.:PA 29 0411036

  • CAS :

    1095822-17-5

  • Molecular Formula : C8H7N3O2

  • Molecular Weight : 177.16

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