Baricitinib was approved in February of 2017 as a second-line orally administered treatment for moderate to severe active rheumatoid arthritis in adults, either as a monotherapy or when combined with methotrexate.Baricitinib is a selective and reversible Janus kinase 1 (JAK1) and 2 (JAK2) inhibitor. Janus kinases belong to the tyrosine protein kinase family and play an important role in the proinflammatory pathway signalling that is frequently over-activated in autoimmune disorders such as rheumatoid arthritis. Reference standards of Baricitinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Baricitinib
Catalogue No.:PA 29 41000
CAS :
Molecular Formula : C16H17N7O2S
Molecular Weight : 371.42
2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetamide
Catalogue No.:PA 29 0411000
Molecular Formula : C16H19N7O3S
Molecular Weight : 389.43
2-(1-(Ethylsulfonyl)-3-(4-(7-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile
Catalogue No.:PA 29 0411001
Molecular Formula : C17H19N7O3S
Molecular Weight : 401.45
2-(1-(Ethylsulfonyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile
Catalogue No.:PA 29 0411002
Molecular Formula : C22H31N7O3SSi
Molecular Weight : 501.68
N-((3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-5-oxotetrahydrofuran-3-yl)methyl)ethanesulfonamide
Catalogue No.:PA 29 0411003
Molecular Formula : C16H18N6O4S
Molecular Weight : 390.42
2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetic acid
Catalogue No.:PA 29 0411004
2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(propylsulfonyl)azetidin-3-yl)acetonitrile
Catalogue No.:PA 29 0411005
Molecular Formula : C17H19N7O2S
Molecular Weight : 385.45
Tert-butyl 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-(cyanomethyl)azetidine-1-carboxylate
Catalogue No.:PA 29 0411006
Molecular Formula : C19H21N7O2
Molecular Weight : 379.42
2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile Dihydrochloride
Catalogue No.:PA 29 0411007
Molecular Formula : C14H15Cl2N7
Molecular Weight : 352.22
Methyl 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetate
Catalogue No.:PA 29 0411008
Molecular Formula : C17H20N6O4S
Molecular Weight : 404.45
2-(1-(Ethylsulfonyl)-3-(4-(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile
Catalogue No.:PA 29 0411009
Molecular Formula : C16H16N8O3S
Molecular Weight : 400.42
2-(1-(Ethylsulfonyl)-3-(1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile
Catalogue No.:PA 29 0411010
Molecular Formula : C10H14N4O2S
Molecular Weight : 254.31
2-(3-(4-(7H-[4,7'-Bipyrrolo[2,3-d]pyrimidin]-4'-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile
Catalogue No.:PA 29 0411011
Molecular Formula : C22H20N10O2S
Molecular Weight : 488.53
2,2'-(1H,1'H-[4,4'-Bipyrazole]-1,1'-diylbis(1-(ethylsulfonyl)azetidine-3,3-diyl))diacetonitrile
Catalogue No.:PA 29 0411012
Molecular Formula : C20H26N8O4S2
Molecular Weight : 506.6
2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile
Catalogue No.:PA 29 0411013
Molecular Formula : C7H10N2O2S
Molecular Weight : 186.23
Tert-butyl 4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylate
Catalogue No.:PA 29 0411014
Molecular Formula : C21H25N7O4S
Molecular Weight : 471.54
4-Chloro-7-nitroso-7H-pyrrolo[2,3-d]pyrimidine
Catalogue No.:PA 29 0411015
Molecular Formula : C6H3ClN4O
Molecular Weight : 182.57
4-Bromo-1-nitroso-1H-pyrazole
Catalogue No.:PA 29 0411016
Molecular Formula : C3H2BrN3O
Molecular Weight : 175.97
1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Catalogue No.:PA 29 0411017
Molecular Formula : C13H23BN2O3
Molecular Weight : 266.15
tert-Butyl 3-(cyanomethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate
Catalogue No.:PA 29 0411018
Molecular Formula : C19H29BN4O4
Molecular Weight : 388.28
(4-(1-(3-(Cyanomethyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl Pivalate
Catalogue No.:PA 29 0411019
Molecular Formula : C20H23N7O2
Molecular Weight : 393.45
(4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl Pivalate
Catalogue No.:PA 29 0411020
Molecular Formula : C22H27N7O4S
Molecular Weight : 485.56
1-Boc-3-(cyanomethylene)azetidine
Catalogue No.:PA 29 0411021
Molecular Formula : C10H14N2O2
Molecular Weight : 194.23
2-(3-(4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile
Catalogue No.:PA 29 0411022
Molecular Formula : C23H27N9O4S2
Molecular Weight : 557.65
tert-Butyl 3-(cyanomethyl)-3-(4-(7-((pivaloyloxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate
Catalogue No.:PA 29 0411023
Molecular Formula : C25H31N7O4
Molecular Weight : 493.57
4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
Catalogue No.:PA 29 0411024
Molecular Formula : C12H18ClN3OSi
Molecular Weight : 283.83
2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-nitrosoazetidin-3-yl)acetonitrile
Catalogue No.:PA 29 0411025
Molecular Formula : C14H12N8O
Molecular Weight : 308.31
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