Belzutifan and its Impurities
Belzutifan, sold under the brand name Welireg, is a medication used for the treatment of von Hippel–Lindau disease-associated renal cell carcinoma. Reference standards of Belzutifan API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
3-(((1S,2S,3S)-2,3-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
3-(((1S,2S,3S)-2,3-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
Catalogue No.:PA 02 2421000
CAS :
1672668-51-7
Molecular Formula : C17H12F3NO4S
Molecular Weight : 383.34
rel-3-(((1R,2R,3S)-2,3-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
rel-3-(((1R,2R,3S)-2,3-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
Catalogue No.:PA 02 2421001
CAS :
2007088-15-3
Molecular Formula : C17H12F3NO4S
Molecular Weight : 383.34
3-(((1R,2S,3R)-2,3-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
3-(((1R,2S,3R)-2,3-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
Catalogue No.:PA 02 2421002
CAS :
3004833-91-1
Molecular Formula : C17H12F3NO4S
Molecular Weight : 383.34
3-Fluoro-5-(((1S,2R,3R)-2-fluoro-1,3-dihydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile
3-Fluoro-5-(((1S,2R,3R)-2-fluoro-1,3-dihydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile
Catalogue No.:PA 02 2421003
CAS :
1672668-57-3
Molecular Formula : C17H13F2NO5S
Molecular Weight : 381.35
3-(((1S,2S,3R)-3-(((1S,2R,3R)-4-(3-Cyano-5-fluorophenoxy)-2-fluoro-3-(2-methoxyethoxy)-7-(methylsulfonyl)-2,3-dihydro-1H-inden-1-yl)oxy)-2-fluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
3-(((1S,2S,3R)-3-(((1S,2R,3R)-4-(3-Cyano-5-fluorophenoxy)-2-fluoro-3-(2-methoxyethoxy)-7-(methylsulfonyl)-2,3-dihydro-1H-inden-1-yl)oxy)-2-fluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
Catalogue No.:PA 02 2421004
CAS :
2738682-47-6
Molecular Formula : C37H30F4N2O10S2
Molecular Weight : 802.76
3-(((1S,2S,3S)-1-(((1R,2S,3S)-7-(3-Cyano-5-fluorophenoxy)-2-fluoro-3-hydroxy-4-(methylsulfonyl)-2,3-dihydro-1H-inden-1-yl)oxy)-2-fluoro-3-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
3-(((1S,2S,3S)-1-(((1R,2S,3S)-7-(3-Cyano-5-fluorophenoxy)-2-fluoro-3-hydroxy-4-(methylsulfonyl)-2,3-dihydro-1H-inden-1-yl)oxy)-2-fluoro-3-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
Catalogue No.:PA 02 2421005
CAS :
2738682-46-5
Molecular Formula : C34H24F4N2O9S2
Molecular Weight : 744.68
3-(((1S,2S,3R)-3-(((1S,2S,3R)-4-(3-Cyano-5-fluorophenoxy)-2,3-difluoro-7-(methylsulfonyl)-2,3-dihydro-1H-inden-1-yl)oxy)-2-fluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
3-(((1S,2S,3R)-3-(((1S,2S,3R)-4-(3-Cyano-5-fluorophenoxy)-2,3-difluoro-7-(methylsulfonyl)-2,3-dihydro-1H-inden-1-yl)oxy)-2-fluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
Catalogue No.:PA 02 2421006
CAS :
2738682-45-4
Molecular Formula : C34H23F5N2O8S2
Molecular Weight : 746.68
3-Fluoro-5-(((1R,2R,3R)-1,2,3-trifluoro-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile
3-Fluoro-5-(((1R,2R,3R)-1,2,3-trifluoro-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile
Catalogue No.:PA 02 2421007
CAS :
2738682-44-3
Molecular Formula : C17H11F4NO3S
Molecular Weight : 385.33
3-Fluoro-5-(((1S,2S,3R)-2-fluoro-1-hydroxy-3-(2-methoxyethoxy)-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile
3-Fluoro-5-(((1S,2S,3R)-2-fluoro-1-hydroxy-3-(2-methoxyethoxy)-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile
Catalogue No.:PA 02 2421008
CAS :
2738682-43-2
Molecular Formula : C20H19F2NO6S
Molecular Weight : 439.43
3-Fluoro-5-((7-(methylsulfonyl)-2,3-dihydrospiro[indene-1,2'-[1,3]dioxolan]-4-yl)oxy)benzonitrile
3-Fluoro-5-((7-(methylsulfonyl)-2,3-dihydrospiro[indene-1,2'-[1,3]dioxolan]-4-yl)oxy)benzonitrile
Catalogue No.:PA 02 2421010
CAS :
1672665-53-0
Molecular Formula : C19H16FNO5S
Molecular Weight : 389.40
3-((3-Bromo-7-(methylsulfonyl)-2,3-dihydrospiro[indene-1,2'-[1,3]dioxolan]-4-yl)oxy)-5-fluorobenzonitrile
3-((3-Bromo-7-(methylsulfonyl)-2,3-dihydrospiro[indene-1,2'-[1,3]dioxolan]-4-yl)oxy)-5-fluorobenzonitrile
Catalogue No.:PA 02 2421011
CAS :
2739737-08-5
Molecular Formula : C19H15BrFNO5S
Molecular Weight : 468.29
