betamethasone and its Impurities
Betamethasone is a corticosteroid that is available as pill, by injection, and as a cream. It is a steroid medication.It is used as a topical cream to relieve skin irritation, such as itching and flaking from eczema.. Reference standards of Betamethasone API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
(6S,8S,9R,10S,11S,13S,14S,16S,17R)-6-Bromo-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
(6S,8S,9R,10S,11S,13S,14S,16S,17R)-6-Bromo-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
Catalogue No.:PA 02 31720
CAS :
1203841-38-6
Molecular Formula : C22H28BrFO5
Molecular Weight : 471.36
(6R,8S,9R,10S,11S,13S,14S,16S,17R)-6-Bromo-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
(6R,8S,9R,10S,11S,13S,14S,16S,17R)-6-Bromo-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
Catalogue No.:PA 02 31760
CAS :
1203841-41-1
Molecular Formula : C22H28BrFO5
Molecular Weight : 471.36
(8S,9R,10S,11S,13S,14S,16S,17R)-9-Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
(8S,9R,10S,11S,13S,14S,16S,17R)-9-Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
Catalogue No.:PA 02 31780
CAS :
560-34-9
Molecular Formula : C22H31FO5
Molecular Weight : 394.48
2-((3aS,3a1S,4aS,4a1R,5aS,6R,7S,8aS,8bS)-4a1-Fluoro-6-hydroxy-3a1,5a,7-trimethyl-3-oxo-3,3a,3a1,4a,4a1,5,5a,6,7,8,8a,8b,9,10-tetradecahydro-2H-cyclopenta[1,2]phenanthro[4,5-bcd]furan-6-yl)-2-oxoethyl Dihydrogen Phosphate
2-((3aS,3a1S,4aS,4a1R,5aS,6R,7S,8aS,8bS)-4a1-Fluoro-6-hydroxy-3a1,5a,7-trimethyl-3-oxo-3,3a,3a1,4a,4a1,5,5a,6,7,8,8a,8b,9,10-tetradecahydro-2H-cyclopenta[1,2]phenanthro[4,5-bcd]furan-6-yl)-2-oxoethyl Dihydrogen Phosphate
Catalogue No.:PA 02 33510
CAS :
NA
Molecular Formula : C22H30FO8P
Molecular Weight : 472.44
Betamethasone Valerate Related Compound A (9-Fluoro-11beta,17-dihydroxy-16beta-methyl-3,20-dioxopre (1069018)
Betamethasone Valerate Related Compound A (9-Fluoro-11beta,17-dihydroxy-16beta-methyl-3,20-dioxopre (1069018)
Catalogue No.:PA USP1069018
CAS :
2240-28-0
Molecular Formula : NA
Molecular Weight : NA
2-(9-Fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15, 16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl Acetate
2-(9-Fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15, 16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl Acetate
Catalogue No.:PAI 02 001010
CAS :
986-24-6
Molecular Formula : C24H31FO6
Molecular Weight : 434.5
2-(9-Fluoro-3,11,17-trihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-hydroxyethyl Acetate
2-(9-Fluoro-3,11,17-trihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-hydroxyethyl Acetate
Catalogue No.:PAI 02 001020
CAS :
NA
Molecular Formula : C24H35FO6
Molecular Weight : 438.53
(E)-2-(9-Fluoro-3,11-dihydroxy-10,13,16-trimethyl-7,8,9,11,12,13,15,16-octahydro-3H-cyclopenta[a]phenanthren-17(6H,10H,14H)-ylidene)ethyl acetate
(E)-2-(9-Fluoro-3,11-dihydroxy-10,13,16-trimethyl-7,8,9,11,12,13,15,16-octahydro-3H-cyclopenta[a]phenanthren-17(6H,10H,14H)-ylidene)ethyl acetate
Catalogue No.:PAI 02 001030
CAS :
NA
Molecular Formula : C24H33FO4
Molecular Weight : 404.51
(E)-2-(9-Fluoro-11-hydroxy-10,13,16- trimethyl-3-oxo-7,8,9,11,12,13,15,16-octahydro-3H-cyclopenta[a]phenanthren- 17(6H,10H,14H)-ylidene)ethyl Acetate
(E)-2-(9-Fluoro-11-hydroxy-10,13,16- trimethyl-3-oxo-7,8,9,11,12,13,15,16-octahydro-3H-cyclopenta[a]phenanthren- 17(6H,10H,14H)-ylidene)ethyl Acetate
Catalogue No.:PAI 02 001040
CAS :
NA
Molecular Formula : C24H31FO4
Molecular Weight : 402.50
(E)-9-Fluoro-11-hydroxy-17-(2-hydroxyethylidene)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
(E)-9-Fluoro-11-hydroxy-17-(2-hydroxyethylidene)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
Catalogue No.:PAI 02 001050
CAS :
NA
Molecular Formula : C22H29FO3
Molecular Weight : 360.46
1-(3-Hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
1-(3-Hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
Catalogue No.:PAI 02 001060
CAS :
NA
Molecular Formula : C21H30O2
Molecular Weight : 314.46
17-Acetyl-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
17-Acetyl-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
Catalogue No.:PAI 02 001070
CAS :
NA
Molecular Formula : C21H28O2
Molecular Weight : 312.45
10,13-Dimethyl-17-(2-methyl-1,3-dioxolan-2-yl)-1,2,6,7,8,9,10,11,12,13,14,15-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolane]
10,13-Dimethyl-17-(2-methyl-1,3-dioxolan-2-yl)-1,2,6,7,8,9,10,11,12,13,14,15-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolane]
Catalogue No.:PAI 02 001080
CAS :
NA
Molecular Formula : C25H36O4
Molecular Weight : 400.55
6a',8a'-Dimethyl-8b'-(2-methyl-1,3-dioxolan-2-yl)-1',2',5',6',6a',6b',7',8',8a',8b',9a',10',10a',10b'-tetradecahydrospiro[[1,3]dioxolane-2,4'-naphtho[2',1':4,5]indeno[1,2-b]oxirene]
6a',8a'-Dimethyl-8b'-(2-methyl-1,3-dioxolan-2-yl)-1',2',5',6',6a',6b',7',8',8a',8b',9a',10',10a',10b'-tetradecahydrospiro[[1,3]dioxolane-2,4'-naphtho[2',1':4,5]indeno[1,2-b]oxirene]
Catalogue No.:PAI 02 001090
CAS :
NA
Molecular Formula : C25H36O5
Molecular Weight : 416.55
10,13,16-Trimethyl-17-(2-methyl-1,3-dioxolan-2-yl)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-ol
10,13,16-Trimethyl-17-(2-methyl-1,3-dioxolan-2-yl)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-ol
Catalogue No.:PAI 02 001100
CAS :
NA
Molecular Formula : C26H40O5
Molecular Weight : 432.59
17-Acetyl-17-hydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
17-Acetyl-17-hydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
Catalogue No.:PAI 02 001110
CAS :
NA
Molecular Formula : C22H32O3
Molecular Weight : 344.49
17-Acetyl-17-hydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
17-Acetyl-17-hydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
Catalogue No.:PAI 02 001120
CAS :
NA
Molecular Formula : C22H30O3
Molecular Weight : 342.47
17-(2-Bromoacetyl)-17-hydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
17-(2-Bromoacetyl)-17-hydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
Catalogue No.:PAI 02 001130
CAS :
NA
Molecular Formula : C22H29BrO3
Molecular Weight : 421.37
2-(17-Hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl Acetate
2-(17-Hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl Acetate
Catalogue No.:PAI 02 001140
CAS :
NA
Molecular Formula : C24H32O5
Molecular Weight : 400.51
(S)-2-((8S,9R,10S,11S,13S,14S,16S,17S)-9-Fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-hydroxyacetic Acid
(S)-2-((8S,9R,10S,11S,13S,14S,16S,17S)-9-Fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-hydroxyacetic Acid
Catalogue No.:PA 02 31800
CAS :
1249-19-0
Molecular Formula : C22H29FO5
Molecular Weight : 392.47
(8R,9S,10S,13S,14R,16S,17R)-8,9-Difluoro-10,13,16-trimethyl-3-oxo-17-(2-(propionyloxy)acetyl)-6,7,8,9,10,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
(8R,9S,10S,13S,14R,16S,17R)-8,9-Difluoro-10,13,16-trimethyl-3-oxo-17-(2-(propionyloxy)acetyl)-6,7,8,9,10,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
Catalogue No.:PA 02 33520
CAS :
NA
Molecular Formula : C28H34F2O6
Molecular Weight : 504.57
