Bosentan Hydrate is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. It is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals . Reference standards of Bosentan Hydrate API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
Bosentan Hydrate
Catalogue No.:PA 02 21000
CAS :
Molecular Formula : C27H31N5O7S
Molecular Weight : 569.63
4-(tert-Butyl)benzenesulfonamide
Catalogue No.:PA 02 21510
Molecular Formula : C10H15NO2S
Molecular Weight : 213.3
4-(tert-Butyl)benzene-1-sulfonyl chloride
Catalogue No.:PA 02 21520
Molecular Formula : C10H13ClO2S
Molecular Weight : 232.73
4-(tert-Butyl)-N-[6-chloro-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl] benzenesulfonamide
Catalogue No.:PA 02 21530
Molecular Formula : C25H24ClN5O4S
Molecular Weight : 526.01
4-(tert-Butyl)-N-[6-hydroxy-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl]benzenesulfonamide
Catalogue No.:PA 02 21540
Molecular Formula : C25H25N5O5S
Molecular Weight : 507.56
6-Chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4(3H)-one
Catalogue No.:PA 02 21550
Molecular Formula : C15H11ClN4O3
Molecular Weight : 330.73
Hydroxy Bosentan
Catalogue No.:PA 02 21560
Molecular Formula : C27H29N5O7S
Molecular Weight : 567.61
4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine
Catalogue No.:PA 02 21570
Molecular Formula : C15H10Cl2N4O2
Molecular Weight : 349.17
4-(tert-Butyl)-N,N-bis(6-chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
Catalogue No.:PA 02 21580
Molecular Formula : C40H33Cl2N9O6S
Molecular Weight : 838.72
N,N'-[5-(2-Methoxyphenoxy)[2,2'-bipyrimidine]-4,6-diyl]bis[4-(1,1-dimethylethyl)benzenesulfonamide]
Catalogue No.:PA 02 21590
Molecular Formula : C35H38N6O6S2
Molecular Weight : 702.84
4-(tert-Butyl)-N-(6-methoxy-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
Catalogue No.:PA 02 21600
Molecular Formula : C26H27N5O5S
Molecular Weight : 521.59
N-(6-(2-Hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)-4-isopropylbenzenesulfonamide
Catalogue No.:PA 02 21610
Molecular Formula : C26H27N5O6S
Molecular Weight : 537.59
Bosentan Dimer Impurity
Catalogue No.:PA 02 21620
Molecular Formula : C52H52N10O10S2
Molecular Weight : 1041.16
2-tert-Butylbenzenesulfonamide
Catalogue No.:PA 02 21630
4-(tert-Butyl)-N-((4-(tert-Butyl)phenyl)sulfonyl)benzenesulfonamide
Catalogue No.:PA 02 0211000
Molecular Formula : C20H27NO4S2
Molecular Weight : 409.56
4-(tert-Butyl)-N-(5-(2-methoxyphenoxy)-6-(vinyloxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
Catalogue No.:PA 02 0211001
Molecular Formula : C27H27N5O5S
Molecular Weight : 533.6
4-(tert-Butyl)-N-(6-ethoxy-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
Catalogue No.:PA 02 0211002
Molecular Formula : C27H29N5O5S
Molecular Weight : 535.62
Desmethyl Bosentan
Catalogue No.:PA 02 0211003
Hydroxy O-Desmethyl Bosentan
Catalogue No.:PA 02 0211004
Molecular Formula : C26H27N5O7S
Molecular Weight : 553.59
2-((6-((4-(tert-Butyl)phenyl)sulfonamido)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)oxy)ethyl Acetate
Catalogue No.:PA 02 0211005
Molecular Formula : C29H31N5O7S
Molecular Weight : 593.66
4-(tert-Butyl)-N-(6-(2-(2-hydroxyethoxy)ethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
Catalogue No.:PA 02 0211006
Molecular Formula : C29H33N5O7S
Molecular Weight : 595.67
Cesium ((4-(tert-butyl)phenyl)sulfonyl)(6-chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)amide
Catalogue No.:PA 02 0211008
Molecular Formula : C25H23ClCsN5O4S
Molecular Weight : 657.91
N-(6-Amino-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)-4-(tert-butyl)benzenesulfonamide
Catalogue No.:PAI 02 021001
Molecular Formula : C25H26N6O4S
Molecular Weight : 506.58
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