bosentan hydrate and its Impurities
Bosentan Hydrate is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. It is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals . Reference standards of Bosentan Hydrate API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below


4-(tert-Butyl)-N-[6-chloro-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl] benzenesulfonamide
4-(tert-Butyl)-N-[6-chloro-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl] benzenesulfonamide
Catalogue No.:PA 02 21530
CAS :
150727-06-3
Molecular Formula : C25H24ClN5O4S
Molecular Weight : 526.01


4-(tert-Butyl)-N-[6-hydroxy-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl]benzenesulfonamide
4-(tert-Butyl)-N-[6-hydroxy-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl]benzenesulfonamide
Catalogue No.:PA 02 21540
CAS :
174227-14-6
Molecular Formula : C25H25N5O5S
Molecular Weight : 507.56


4-(tert-Butyl)-N,N-bis(6-chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
4-(tert-Butyl)-N,N-bis(6-chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
Catalogue No.:PA 02 21580
CAS :
NA
Molecular Formula : C40H33Cl2N9O6S
Molecular Weight : 838.72

![N,N'-[5-(2-Methoxyphenoxy)[2,2'-bipyrimidine]-4,6- PA 02 21590](https://www.pharmaffiliates.com/pimages/PA0221590.jpg)
N,N'-[5-(2-Methoxyphenoxy)[2,2'-bipyrimidine]-4,6-diyl]bis[4-(1,1-dimethylethyl)benzenesulfonamide]
N,N'-[5-(2-Methoxyphenoxy)[2,2'-bipyrimidine]-4,6-diyl]bis[4-(1,1-dimethylethyl)benzenesulfonamide]
Catalogue No.:PA 02 21590
CAS :
1218951-81-5
Molecular Formula : C35H38N6O6S2
Molecular Weight : 702.84


N-(6-(2-Hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)-4-isopropylbenzenesulfonamide
N-(6-(2-Hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)-4-isopropylbenzenesulfonamide
Catalogue No.:PA 02 21610
CAS :
1268612-24-3
Molecular Formula : C26H27N5O6S
Molecular Weight : 537.59


4-(tert-Butyl)-N-(5-(2-methoxyphenoxy)-6-(vinyloxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
4-(tert-Butyl)-N-(5-(2-methoxyphenoxy)-6-(vinyloxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
Catalogue No.:PA 02 0211001
CAS :
1257099-44-7
Molecular Formula : C27H27N5O5S
Molecular Weight : 533.6


4-(tert-Butyl)-N-(6-ethoxy-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
4-(tert-Butyl)-N-(6-ethoxy-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
Catalogue No.:PA 02 0211002
CAS :
157415-45-7
Molecular Formula : C27H29N5O5S
Molecular Weight : 535.62


2-((6-((4-(tert-Butyl)phenyl)sulfonamido)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)oxy)ethyl Acetate
2-((6-((4-(tert-Butyl)phenyl)sulfonamido)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)oxy)ethyl Acetate
Catalogue No.:PA 02 0211005
CAS :
1160515-53-6
Molecular Formula : C29H31N5O7S
Molecular Weight : 593.66


4-(tert-Butyl)-N-(6-(2-(2-hydroxyethoxy)ethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
4-(tert-Butyl)-N-(6-(2-(2-hydroxyethoxy)ethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
Catalogue No.:PA 02 0211006
CAS :
1257099-43-6
Molecular Formula : C29H33N5O7S
Molecular Weight : 595.67


Cesium ((4-(tert-butyl)phenyl)sulfonyl)(6-chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)amide
Cesium ((4-(tert-butyl)phenyl)sulfonyl)(6-chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)amide
Catalogue No.:PA 02 0211008
CAS :
1218951-79-1
Molecular Formula : C25H23ClCsN5O4S
Molecular Weight : 657.91