bosentan and its Impurities
Bosentan is used to treat people with moderate pulmonary arterial hypertension and to reduce the number of digital ulcers. It is available as film-coated tablets or as dispersable tablets for oral suspension.. Reference standards of Bosentan API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below


Bosentan Related Compound C (1,2-bis({6-[4-(tert-butyl)phenylsulfonamido]-5-(2-methoxyphenoxy)-[2,2 (1076148)
Bosentan Related Compound C (1,2-bis({6-[4-(tert-butyl)phenylsulfonamido]-5-(2-methoxyphenoxy)-[2,2 (1076148)
Catalogue No.:PA USP1076148
CAS :
1097263-60-9
Molecular Formula : NA
Molecular Weight : NA


Bosentan Related Compound A (4-(tert-butyl)-N-[6-chloro-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-y (1076126)
Bosentan Related Compound A (4-(tert-butyl)-N-[6-chloro-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-y (1076126)
Catalogue No.:PA USP1076126
CAS :
150727-06-3
Molecular Formula : NA
Molecular Weight : NA


Bosentan Related Compound B (4-(tert-butyl)-N-[6-hydroxy-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4- (1076137)
Bosentan Related Compound B (4-(tert-butyl)-N-[6-hydroxy-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4- (1076137)
Catalogue No.:PA USP1076137
CAS :
174227-14-6
Molecular Formula : NA
Molecular Weight : NA


4-(Tert-butyl)-N-(5-hydroxy-6-(2-(2-hydroxyethoxy)ethoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
4-(Tert-butyl)-N-(5-hydroxy-6-(2-(2-hydroxyethoxy)ethoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
Catalogue No.:PA 29 0131004
CAS :
1257099-41-4
Molecular Formula : C22H27N5O6S
Molecular Weight : 489.55


Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(ethenyloxy)-5-hydroxy[2,2′-bipyrimidin]-4-yl]-
Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(ethenyloxy)-5-hydroxy[2,2′-bipyrimidin]-4-yl]-
Catalogue No.:PA 29 0131005
CAS :
1257099-42-5
Molecular Formula : C20H21N5O4S
Molecular Weight : 427.48


N-(6-Chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)-4-(2-methyl-1-((tetrahydro-2H-pyran-2-yl)oxy)propan-2-yl)benzenesulfonamide
N-(6-Chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)-4-(2-methyl-1-((tetrahydro-2H-pyran-2-yl)oxy)propan-2-yl)benzenesulfonamide
Catalogue No.:PAI 29 013018
CAS :
NA
Molecular Formula : C30H32ClN5O6S
Molecular Weight : 626.13


N-(6-(2-Hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)-4-(2-methyl-1-((tetrahydro-2H-pyran-2-yl)oxy)propan-2-yl)benzenesulfonamide
N-(6-(2-Hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)-4-(2-methyl-1-((tetrahydro-2H-pyran-2-yl)oxy)propan-2-yl)benzenesulfonamide
Catalogue No.:PAI 29 013019
CAS :
NA
Molecular Formula : C32H37N5O8S
Molecular Weight : 651.74


Ethyl 2-(4-(N-(6-chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)sulfamoyl)phenyl)-2-methylpropanoate
Ethyl 2-(4-(N-(6-chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)sulfamoyl)phenyl)-2-methylpropanoate
Catalogue No.:PAI 29 013020
CAS :
NA
Molecular Formula : C27H26ClN5O6S
Molecular Weight : 584.04


Ethyl 2-(4-(N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)sulfamoyl)phenyl)-2-methylpropanoate
Ethyl 2-(4-(N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)sulfamoyl)phenyl)-2-methylpropanoate
Catalogue No.:PAI 29 013021
CAS :
NA
Molecular Formula : C29H31N5O8S
Molecular Weight : 609.65


2-(4-(N-(6-(2-Hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)sulfamoyl)phenyl)-2-methylpropanoic Acid
2-(4-(N-(6-(2-Hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)sulfamoyl)phenyl)-2-methylpropanoic Acid
Catalogue No.:PAI 29 013022
CAS :
NA
Molecular Formula : C27H27N5O8S
Molecular Weight : 581.6


4-(tert-Butyl)-N-(6-(2-chloroethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
4-(tert-Butyl)-N-(6-(2-chloroethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
Catalogue No.:PA 29 0131014
CAS :
1855932-53-4
Molecular Formula : C27H28ClN5O5S
Molecular Weight : 570.06