bosutinib and its Impurities
Bosutinib is used to treat chronic myeloid leukaemia that has an abnormal chromosome called the Philadelphia chromosome. It is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity.. Reference standards of Bosutinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
 
	
			                                   
																				4-((3,5-Dichloro-4-methoxyphenyl)amino)-6-methoxy-7-(3-(1-methylpiperidin-4-yl)propoxy)quinoline-3-carbonitrile
4-((3,5-Dichloro-4-methoxyphenyl)amino)-6-methoxy-7-(3-(1-methylpiperidin-4-yl)propoxy)quinoline-3-carbonitrile
- Catalogue No.:PA 02 92510 
- CAS : - NA
- Molecular Formula : C27H30Cl2N4O3 
- Molecular Weight : 529.46 
 
	
			                                   
																				4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(piperazin-1-yl)propoxy)quinoline-3-carbonitrile
4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(piperazin-1-yl)propoxy)quinoline-3-carbonitrile
- Catalogue No.:PA 02 92540 
- CAS : - 380843-81-2
- Molecular Formula : C25H27Cl2N5O3 
- Molecular Weight : 516.42 
 
	
			                                   
																				4-((2,4-Dichloro-5-hydroxyphenyl)amino)-6-hydroxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile
4-((2,4-Dichloro-5-hydroxyphenyl)amino)-6-hydroxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile
- Catalogue No.:PA 02 0921006 
- CAS : - 2468737-94-0
- Molecular Formula : C24H25Cl2N5O3 
- Molecular Weight : 502.4 
 
	
			                                   
																				2-Cyano-N-(2,4-dichloro-5-methoxy phenyl)-3-{4-methoxy-3-[3-(4-methyl piperazin-1-yl)-propoxy]- phenylamino} acrylamide
2-Cyano-N-(2,4-dichloro-5-methoxy phenyl)-3-{4-methoxy-3-[3-(4-methyl piperazin-1-yl)-propoxy]- phenylamino} acrylamide
- Catalogue No.:PA 02 0921009 
- CAS : - 846023-56-1
- Molecular Formula : C26H31Cl2N5O4 
- Molecular Weight : 548.47 
 
	
			                                   
																				7,7'-((Piperazine-1,4-diylbis(propane-3,1-diyl))bis(oxy))bis(4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxyquinoline-3-carbonitrile)
7,7'-((Piperazine-1,4-diylbis(propane-3,1-diyl))bis(oxy))bis(4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxyquinoline-3-carbonitrile)
- Catalogue No.:PA 02 0921011 
- CAS : - 2095306-26-4
- Molecular Formula : C46H44Cl4N8O6 
- Molecular Weight : 946.71 
 
	
			                                   
																				7,7'-(Propane-1,3-diylbis(oxy))bis(4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxyquinoline-3-carbonitrile)
7,7'-(Propane-1,3-diylbis(oxy))bis(4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxyquinoline-3-carbonitrile)
- Catalogue No.:PA 02 0921028 
- CAS : - 2095306-27-5
- Molecular Formula : C39H30Cl4N6O6 
- Molecular Weight : 820.51 
 
	
			                                   
																				4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-nitrosopiperazin-1-yl)propoxy)quinoline-3-carbonitrile
4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-nitrosopiperazin-1-yl)propoxy)quinoline-3-carbonitrile
- Catalogue No.:PA 02 0921030 
- CAS : - NA
- Molecular Formula : C25H26Cl2N6O4 
- Molecular Weight : 545.42 
 
	
			                                   
																				7-(3-Chloropropoxy)-4-((2,4-dichloro-5-hydroxyphenyl)amino)-6-methoxyquinoline-3-carbonitrile
7-(3-Chloropropoxy)-4-((2,4-dichloro-5-hydroxyphenyl)amino)-6-methoxyquinoline-3-carbonitrile
- Catalogue No.:PAI 02 092001 
- CAS : - NA
- Molecular Formula : C20H16Cl3N3O3 
- Molecular Weight : 452.72 
 
	
			                                   
																				tert-Butyl 4-(3-((3-cyano-4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxyquinolin-7-yl)oxy)propyl)piperazine-1-carboxylate
tert-Butyl 4-(3-((3-cyano-4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxyquinolin-7-yl)oxy)propyl)piperazine-1-carboxylate
- Catalogue No.:PAI 02 092002 
- CAS : - 1613270-82-8
- Molecular Formula : C30H35Cl2N5O5 
- Molecular Weight : 616.54 
 
	
			                                   
																				4-((3-Bromopropyl)(2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile
4-((3-Bromopropyl)(2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile
- Catalogue No.:PAI 02 092004 
- CAS : - NA
- Molecular Formula : C29H34BrCl2N5O3 
- Molecular Weight : 651.43 
 
	
			                                   
																				4-((2,4-Dichloro-5-methoxyphenyl)amino)-7-(3-((2,4-dichloro-5-methoxyphenyl)amino)propoxy)-6-methoxyquinoline-3-carbonitrile
4-((2,4-Dichloro-5-methoxyphenyl)amino)-7-(3-((2,4-dichloro-5-methoxyphenyl)amino)propoxy)-6-methoxyquinoline-3-carbonitrile
- Catalogue No.:PAI 02 092010 
- CAS : - NA
- Molecular Formula : C28H24Cl4N4O4 
- Molecular Weight : 622.32 
 
	
			                                   
																				2-Cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-((4-methoxy-3-(3-(4-nitrosopiperazin-1-yl)propoxy)phenyl)amino)acrylamide
2-Cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-((4-methoxy-3-(3-(4-nitrosopiperazin-1-yl)propoxy)phenyl)amino)acrylamide
- Catalogue No.:PA 02 0921034 
- CAS : - NA
- Molecular Formula : C25H28Cl2N6O5 
- Molecular Weight : 563.44 
 
	
			                                   
																				N,N'-((Propane-1,3-diylbis(oxy))bis(3-cyano-6-methoxyquinoline-7,4-diyl))bis(N-(2,4-dichloro-5-methoxyphenyl)nitrous amide)
N,N'-((Propane-1,3-diylbis(oxy))bis(3-cyano-6-methoxyquinoline-7,4-diyl))bis(N-(2,4-dichloro-5-methoxyphenyl)nitrous amide)
- Catalogue No.:PA 02 0921036 
- CAS : - NA
- Molecular Formula : C39H28Cl4N8O8 
- Molecular Weight : 878.5 
 
	
			                                   
																				N,N'-(((Piperazine-1,4-diylbis(propane-3,1-diyl))bis(oxy))bis(3-cyano-6-methoxyquinoline-7,4-diyl))bis(N-(2,4-dichloro-5-methoxyphenyl)nitrous amide)
N,N'-(((Piperazine-1,4-diylbis(propane-3,1-diyl))bis(oxy))bis(3-cyano-6-methoxyquinoline-7,4-diyl))bis(N-(2,4-dichloro-5-methoxyphenyl)nitrous amide)
- Catalogue No.:PA 02 0921037 
- CAS : - NA
- Molecular Formula : C46H42Cl4N10O8 
- Molecular Weight : 1004.7 
 
	
			                                   
																				N-(3-Cyano-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yl)-N-(2,4-dichloro-5-methoxyphenyl)nitrous amide
N-(3-Cyano-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yl)-N-(2,4-dichloro-5-methoxyphenyl)nitrous amide
- Catalogue No.:PA 02 0921038 
- CAS : - NA
- Molecular Formula : C26H28Cl2N6O4 
- Molecular Weight : 559.45 

 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				![4-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-hydroxy- PA 02 0921015](https://www.pharmaffiliates.com/pimages/PA020921015.jpg) 
																				![4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6,7-dimeth PA 02 0921016](https://www.pharmaffiliates.com/pimages/PA020921016.jpg) 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
 
 
 
