brigatinib and its Impurities
Brigatinib acts as both an anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR) inhibitor. It is a small molecule targeted cancer therapy being developed by ARIAD Pharmaceuticals, Inc.. Reference standards of Brigatinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
2,4-Pyrimidinediamine, 5-chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(1-piperazinyl)-1-piperidinyl]phenyl]
2,4-Pyrimidinediamine, 5-chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(1-piperazinyl)-1-piperidinyl]phenyl]
Catalogue No.:PA 29 0441000
CAS :
1197958-75-0
Molecular Formula : C28H37ClN7O2P
Molecular Weight : 570.07
N-(5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)nitrous amide
N-(5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)nitrous amide
Catalogue No.:PA 29 0441001
CAS :
NA
Molecular Formula : C29H38ClN8O3P
Molecular Weight : 613.1
N-(5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)-N-(2-(dimethylphosphoryl)phenyl)nitrous amide
N-(5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)-N-(2-(dimethylphosphoryl)phenyl)nitrous amide
Catalogue No.:PA 29 0441002
CAS :
NA
Molecular Formula : C29H38ClN8O3P
Molecular Weight : 613.1
N-(5-Chloro-4-((2-(dimethylphosphoryl)phenyl)(nitroso)amino)pyrimidin-2-yl)-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)nitrous amide
N-(5-Chloro-4-((2-(dimethylphosphoryl)phenyl)(nitroso)amino)pyrimidin-2-yl)-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)nitrous amide
Catalogue No.:PA 29 0441003
CAS :
NA
Molecular Formula : C29H37ClN9O4P
Molecular Weight : 642.1
5-Chloro-N2,N4-bis(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine
5-Chloro-N2,N4-bis(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine
Catalogue No.:PA 29 0441005
CAS :
NA
Molecular Formula : C38H55ClN10O2
Molecular Weight : 719.38
(2-((5-Chloro-2-((4-(4-hydroxypiperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
(2-((5-Chloro-2-((4-(4-hydroxypiperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
Catalogue No.:PA 29 0441006
CAS :
1197959-30-0
Molecular Formula : C24H29ClN5O3P
Molecular Weight : 501.95
2,5-Dichloro-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidin-4-amine
2,5-Dichloro-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidin-4-amine
Catalogue No.:PA 29 0441007
CAS :
1259274-28-6
Molecular Formula : C21H28Cl2N6O
Molecular Weight : 451.4
N-(5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)nitrous amide
N-(5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)nitrous amide
Catalogue No.:PA 29 0441009
CAS :
NA
Molecular Formula : C29H38ClN8O3P
Molecular Weight : 613.1
N-(5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)-N-(2-(dimethylphosphoryl)phenyl)nitrous amide
N-(5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)-N-(2-(dimethylphosphoryl)phenyl)nitrous amide
Catalogue No.:PA 29 0441011
CAS :
NA
Molecular Formula : C29H38ClN8O3P
Molecular Weight : 613.1
