brinzolamide and its Impurities
Brinzolamide is a highly specific, non-competitive, reversible carbonic anhydrase inhibitor. It is used to treat high pressure inside the eye due to glaucoma or other eye diseases. Lowering high pressure inside the eye helps to prevent blindness.. Reference standards of Brinzolamide API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below


4-(N-Ethyl-4-methylphenylsulfonamido)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
4-(N-Ethyl-4-methylphenylsulfonamido)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
Catalogue No.:PA 02 80540
CAS :
NA
Molecular Formula : C19H27N3O7S4
Molecular Weight : 537.69


(S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Dioxide
(S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Dioxide
Catalogue No.:PA 02 80550
CAS :
154127-42-1
Molecular Formula : C10H16N2O6S3
Molecular Weight : 356.44


Brinzolamide Related Compound A ((S)-(-)-4-ethylamino-2,3-dihydro-2-(3-methoxypropyl)-4H-thieno-[3, (1076374)
Brinzolamide Related Compound A ((S)-(-)-4-ethylamino-2,3-dihydro-2-(3-methoxypropyl)-4H-thieno-[3, (1076374)
Catalogue No.:PA USP1076374
CAS :
154127-19-2
Molecular Formula : NA
Molecular Weight : NA


Brinzolamide Related Compound B ((R)-4-amino-2,3-dihydro-2-(3-methoxypropyl)-4H-thieno-[3,2,e]-thia (1076385)
Brinzolamide Related Compound B ((R)-4-amino-2,3-dihydro-2-(3-methoxypropyl)-4H-thieno-[3,2,e]-thia (1076385)
Catalogue No.:PA USP1076385
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA


(R)-4-Amino-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide Oxalate
(R)-4-Amino-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide Oxalate
Catalogue No.:PA 02 80560
CAS :
NA
Molecular Formula : C12H19N3O9S3
Molecular Weight : 445.48


(R)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Dioxide
(R)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Dioxide
Catalogue No.:PA 02 80580
CAS :
165117-54-4
Molecular Formula : C10H16N2O6S3
Molecular Weight : 356.43


6'-Chloro-2',3'-dihydro-spiro[1,3-dioxolane-2,4'-[4H]thieno[3,2-e][1,2]thiazine] 1',1'-Dioxide
6'-Chloro-2',3'-dihydro-spiro[1,3-dioxolane-2,4'-[4H]thieno[3,2-e][1,2]thiazine] 1',1'-Dioxide
Catalogue No.:PA 02 0801004
CAS :
1206597-10-5
Molecular Formula : C8H8ClNO4S2
Molecular Weight : 281.73


(R)-4-(Ethyl(2-hydroxyethyl)amino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
(R)-4-(Ethyl(2-hydroxyethyl)amino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
Catalogue No.:PA 02 0801005
CAS :
NA
Molecular Formula : C14H25N3O6S3
Molecular Weight : 427.55


4-Amino-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
4-Amino-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
Catalogue No.:PA 02 0801006
CAS :
2109554-77-8
Molecular Formula : C10H17N3O5S3
Molecular Weight : 355.44


(R)-4-(Ethyl(methyl)amino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
(R)-4-(Ethyl(methyl)amino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
Catalogue No.:PA 02 0801008
CAS :
2245358-54-5
Molecular Formula : C13H23N3O5S3
Molecular Weight : 397.52


 (R)-4-(Ethylamino)-2-methyl-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
(R)-4-(Ethylamino)-2-methyl-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
Catalogue No.:PA 02 0801009
CAS :
138890-58-1
Molecular Formula : C9H15N3O4S3
Molecular Weight : 325.42


(R)-2-(3-Methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
(R)-2-(3-Methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
Catalogue No.:PA 02 0801011
CAS :
308358-88-5
Molecular Formula : C11H19N3O5S3
Molecular Weight : 369.47


(S)-2-(3-Methoxypropyl)-1,1-dioxido-6-sulfamoyl-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazin-4-yl 4-methylbenzenesulfonate
(S)-2-(3-Methoxypropyl)-1,1-dioxido-6-sulfamoyl-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazin-4-yl 4-methylbenzenesulfonate
Catalogue No.:PAI 02 080001
CAS :
NA
Molecular Formula : C17H22N2O8S4
Molecular Weight : 510.61


(R)-4-Azido-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
(R)-4-Azido-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
Catalogue No.:PAI 02 080002
CAS :
NA
Molecular Formula : C10H15N5O5S3
Molecular Weight : 381.44


(S)-6-Chloro-4-hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine 1,1-dioxide
(S)-6-Chloro-4-hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine 1,1-dioxide
Catalogue No.:PA 02 0801012
CAS :
160982-13-8
Molecular Formula : C10H14ClNO4S2
Molecular Weight : 311.8


(R)-4-(Ethylamino)-2-(3-((R)-4-(ethylamino)-1,1-dioxido-6-sulfamoyl-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazin-2-yl)propyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
(R)-4-(Ethylamino)-2-(3-((R)-4-(ethylamino)-1,1-dioxido-6-sulfamoyl-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazin-2-yl)propyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
Catalogue No.:PA 02 0801014
CAS :
NA
Molecular Formula : C19H30N6O8S6
Molecular Weight : 662.84


(R)-N-Ethyl-N'-((4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxido-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazin-6-yl)sulfonyl)-3-oxobutanimidamide
(R)-N-Ethyl-N'-((4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxido-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazin-6-yl)sulfonyl)-3-oxobutanimidamide
Catalogue No.:PA 02 0801016
CAS :
NA
Molecular Formula : C18H30N4O6S3
Molecular Weight : 494.64