bromocriptine and its Impurities
Bromocriptine is used to treat acromegaly and conditions associated with hyperprolactinemia like amenorrhea, infertility, and hypogonadism, prolactin-secreting adenomas; it is also used to prevent ovarian hyperstimulation syndrome. It was patented in 1968 and approved for medical use in 1975.. Reference standards of Bromocriptine API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
Bromocriptine - Impurity F
(6aR,9R)-5-Bromo-N-[(2S,5S,10aS,10bS)-10b-hydroxy-2-(1-methylethyl)-5-(2- methylpropyl)-3,6-dioxooctahydro-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-7- methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
Catalogue No.:PA 02 49060
CAS :
82773-21-5
Molecular Formula : C32H40BrN5O5
Molecular Weight : 654.61
Bromocriptine - Impurity G
(6aR,9R)-5-Bromo-N-[(2R,5S,10aS,10bS)-10b-methoxy-2-(1-methylethyl)-5-(2- methylpropyl)-3,6-dioxooctahydro-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
Catalogue No.:PA 02 49070
CAS :
1349233-25-5
Molecular Formula : C33H42BrN5O5
Molecular Weight : 668.63
(6aR,9R)-5-Bromo-N-((2R,5S,10aS,10bS)-2-((R)-sec-butyl)-10b-hydroxy-5-isobutyl-3,6-dioxooctahydro-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
(6aR,9R)-5-Bromo-N-((2R,5S,10aS,10bS)-2-((R)-sec-butyl)-10b-hydroxy-5-isobutyl-3,6-dioxooctahydro-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
Catalogue No.:PA 02 0491000
CAS :
157135-99-4
Molecular Formula : C33H42BrN5O5
Molecular Weight : 668.63
(6aR,9R)-5-Bromo-N-((2R,5S,10aS,10bS)-10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxooctahydro-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4-nitroso-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
(6aR,9R)-5-Bromo-N-((2R,5S,10aS,10bS)-10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxooctahydro-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4-nitroso-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
Catalogue No.:PA 02 0491001
CAS :
NA
Molecular Formula : C32H39BrN6O6
Molecular Weight : 683.6
(6aR,6'aR,9R)-5-Bromo-N9,N9'-bis((2R,5S,10bS)-10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxooctahydro-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7,7'-dimethyl-4',6a,6',6'a,7,7',8,8',9,9'-decahydro-6H-[4,5'-biindolo[4,3-fg]quinoline]-9,9'-dicarboxamide
(6aR,6'aR,9R)-5-Bromo-N9,N9'-bis((2R,5S,10bS)-10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxooctahydro-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7,7'-dimethyl-4',6a,6',6'a,7,7',8,8',9,9'-decahydro-6H-[4,5'-biindolo[4,3-fg]quinoline]-9,9'-dicarboxamide
Catalogue No.:PA 02 0491002
CAS :
NA
Molecular Formula : C64H79BrN10O10
Molecular Weight : 1228.3