Cabotegravir and its Impurities
Cabotegravir is also known as S/GSK1265744 or GSK744. It is an analog of dolutegravir, prevents viral DNA integration into the host genome and inhibits HIV replication. Reference standards of Cabotegravir API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
(3S,11aR)-N-(2,4-Difluorobenzyl)-3-methyl-5,7-dioxo-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
(3S,11aR)-N-(2,4-Difluorobenzyl)-3-methyl-5,7-dioxo-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
Catalogue No.:PA 03 3511001
CAS :
2170827-76-4
Molecular Formula : C25H27F2N3O10
Molecular Weight : 567.5
(3S,11aR)-N-(2,4-Difluorobenzyl)-6-methoxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
(3S,11aR)-N-(2,4-Difluorobenzyl)-6-methoxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
Catalogue No.:PA 03 3511005
CAS :
1335210-25-7
Molecular Formula : C20H19F2N3O5
Molecular Weight : 419.38
(3S,11aR)-N-(4-Fluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
(3S,11aR)-N-(4-Fluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
Catalogue No.:PA 03 3511006
CAS :
1309560-71-1
Molecular Formula : C19H18FN3O5
Molecular Weight : 387.37
(3S,11aR)-N-Benzyl-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
(3S,11aR)-N-Benzyl-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
Catalogue No.:PA 03 3511007
CAS :
2883234-41-9
Molecular Formula : C19H19N3O5
Molecular Weight : 369.38
(3S,11aR)-6-Methoxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic Acid
(3S,11aR)-6-Methoxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic Acid; (3S,11aR)-2,3,5,7,11,11a-Hexahydro-6-methoxy-3-methyl-5,7-dioxooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic Acid;
Catalogue No.:PA 03 3511008
CAS :
1335210-24-6
Molecular Formula : C13H14N2O6
Molecular Weight : 294.26
(3S,11aR)-N-(2-Fluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
(3S,11aR)-N-(2-Fluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
Catalogue No.:PA 03 3511009
CAS :
2883234-42-0
Molecular Formula : C19H18FN3O5
Molecular Weight : 387.37
(3S,11aR)-N-(2,6-Difluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
(3S,11aR)-N-(2,6-Difluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
Catalogue No.:PA 03 3511010
CAS :
NA
Molecular Formula : C19H17F2N3O5
Molecular Weight : 405.36
(S)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(1-hydroxypropan-2-yl)-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide
(S)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(1-hydroxypropan-2-yl)-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide
Catalogue No.:PA 03 3511011
CAS :
2883234-39-5
Molecular Formula : C19H17F2N3O5
Molecular Weight : 405.36
(3S,11aR)-6-Hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic acid
(3S,11aR)-6-Hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic acid
Catalogue No.:PA 03 3511012
CAS :
2757656-11-2
Molecular Formula : C12H12N2O6
Molecular Weight : 280.24
