cabozantinib and its Impurities
Cabozantinib is used in two forms. A capsule form is used since 2012 to treat medullary thyroid cancer and a tablet form is used since 2016 as a second line treatment for renal cell carcinoma.. Reference standards of Cabozantinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
1-((4-((7-Methoxy-6-(sulfooxy)quinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylic Acid
1-((4-((7-Methoxy-6-(sulfooxy)quinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylic Acid
Catalogue No.:PA 30 0621010
CAS :
1628530-37-9
Molecular Formula : C21H18N2O9S
Molecular Weight : 474.44
N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluoro-2-hydroxyphenyl)cyclopropane-1,1-dicarboxamide
N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluoro-2-hydroxyphenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 0621011
CAS :
1628530-38-0
Molecular Formula : C28H24FN3O6
Molecular Weight : 517.51
N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(2-fluorophenyl)cyclopropane-1,1-dicarboxamide
N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(2-fluorophenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 0621012
CAS :
NA
Molecular Formula : C28H24FN3O5
Molecular Weight : 501.51
N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(3-fluorophenyl)cyclopropane-1,1-dicarboxamide
N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(3-fluorophenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 0621014
CAS :
NA
Molecular Formula : C28H24FN3O5
Molecular Weight : 501.51
N-(4-Fluorophenyl)-N-(4-((7-hydroxy-6-methoxyquinolin-4-yl)oxy)phenyl)cyclopropane-1,1-dicarboxamide
N-(4-Fluorophenyl)-N-(4-((7-hydroxy-6-methoxyquinolin-4-yl)oxy)phenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 0621024
CAS :
1628530-42-6
Molecular Formula : C27H22FN3O5
Molecular Weight : 487.49
N-(4-Fluorophenyl)-N-(4-((6-hydroxy-7-methoxyquinolin-4-yl)oxy)phenyl)cyclopropane-1,1-dicarboxamide
N-(4-Fluorophenyl)-N-(4-((6-hydroxy-7-methoxyquinolin-4-yl)oxy)phenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 0621025
CAS :
1628530-47-1
Molecular Formula : C27H22FN3O5
Molecular Weight : 487.49
(2S,3S,4S,5R,6S)-6-((4-(4-(1-((4-Fluorophenyl)carbamoyl)cyclopropane-1-carboxamido)phenoxy)-6-methoxyquinolin-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid
(2S,3S,4S,5R,6S)-6-((4-(4-(1-((4-Fluorophenyl)carbamoyl)cyclopropane-1-carboxamido)phenoxy)-6-methoxyquinolin-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid
Catalogue No.:PA 30 0621030
CAS :
NA
Molecular Formula : C33H30FN3O11
Molecular Weight : 663.61
4-((4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)amino)-3-((4-fluorophenyl)carbamoyl)-4-oxobutyl (Z)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carbimidate
4-((4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)amino)-3-((4-fluorophenyl)carbamoyl)-4-oxobutyl (Z)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carbimidate
Catalogue No.:PA 30 0621033
CAS :
NA
Molecular Formula : C56H48F2N6O10
Molecular Weight : 1003.03