cangrelor and its Impurities
According to recent phase 3 randomized trials, a cangrelor–clopidogrel combination is safe and has been found to be more effective than standard clopidogrel treatment at reducing ischemic events in the heart, without increasing major bleeding in the treatment of stenotic coronary arteries. It is a P2Y12 inhibitor FDA approved as of June 2015 as an antiplatelet drug for intravenous application. Reference standards of Cangrelor API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below

![N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl) PA 30 91550](https://www.pharmaffiliates.com/pimages/PA3091550.jpg)
N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-adenosine, 5'-(hydrogen P-1H-imidazol-1-ylphosphonate)
N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-adenosine, 5'-(hydrogen P-1H-imidazol-1-ylphosphonate)
Catalogue No.:PA 30 91550
CAS :
847460-53-1
Molecular Formula : C16H23F3N5O7PS2
Molecular Weight : 549.48


((2R,3S,4R,5R)-3,4-Dihydroxy-5-(6-((2-(methylthio)ethyl)amino)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl hydrogen 1H-imidazol-1-ylphosphonate
((2R,3S,4R,5R)-3,4-Dihydroxy-5-(6-((2-(methylthio)ethyl)amino)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl hydrogen 1H-imidazol-1-ylphosphonate
Catalogue No.:PA 30 91580
CAS :
1054332-15-8
Molecular Formula : C19H25F3N7O6PS2
Molecular Weight : 599.54


(2R,3R,4R,5R)-2-(6-Acetamido-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)-5-(acetoxymethyl)tetrahydrofuran-3,4-diyl Diacetate
(2R,3R,4R,5R)-2-(6-Acetamido-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)-5-(acetoxymethyl)tetrahydrofuran-3,4-diyl Diacetate
Catalogue No.:PA 30 0911000
CAS :
163706-52-3
Molecular Formula : C21H24F3N5O8S
Molecular Weight : 563.51


(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(6-(N-(2-(methylthio)ethyl)acetamido)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl Diacetate
(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(6-(N-(2-(methylthio)ethyl)acetamido)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl Diacetate
Catalogue No.:PA 30 0911001
CAS :
163706-57-8
Molecular Formula : C24H30F3N5O8S2
Molecular Weight : 637.65


((2S,3R,4S,5S)-3,4-Dihydroxy-5-(6-((2-(methylthio)ethyl)amino)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl Dihydrogen Phosphate
((2S,3R,4S,5S)-3,4-Dihydroxy-5-(6-((2-(methylthio)ethyl)amino)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl Dihydrogen Phosphate
Catalogue No.:PA 30 0911004
CAS :
2250335-99-8
Molecular Formula : C16H23F3N5O7PS2
Molecular Weight : 549.48


N-(9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-6-yl)-N-(2-(methylthio)ethyl)nitrous amide
N-(9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-6-yl)-N-(2-(methylthio)ethyl)nitrous amide
Catalogue No.:PA 30 0911008
CAS :
NA
Molecular Formula : C16H21F3N6O5S2
Molecular Weight : 498.5


N-(2-(Methylsulfinyl)ethyl)-N-(9-nitroso-2-((3,3,3-trifluoropropyl)thio)-9H-purin-6-yl)nitrous amide
N-(2-(Methylsulfinyl)ethyl)-N-(9-nitroso-2-((3,3,3-trifluoropropyl)thio)-9H-purin-6-yl)nitrous amide
Catalogue No.:PA 30 0911012
CAS :
NA
Molecular Formula : C11H12F3N7O3S2
Molecular Weight : 411.38


((2R,3S,4R,5R)-3,4-Dihydroxy-5-(6-((2-(methylthio)ethyl)(nitroso)amino)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate
((2R,3S,4R,5R)-3,4-Dihydroxy-5-(6-((2-(methylthio)ethyl)(nitroso)amino)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate
Catalogue No.:PA 30 0911013
CAS :
NA
Molecular Formula : C16H22F3N6O8PS2
Molecular Weight : 578.47


N-(9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-6-yl)-N-(2-(methylthio)ethyl)nitrous amide
N-(9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-6-yl)-N-(2-(methylthio)ethyl)nitrous amide
Catalogue No.:PA 30 0911014
CAS :
NA
Molecular Formula : C16H21F3N6O5S2
Molecular Weight : 498.5


N-(2-(Methylthio)ethyl)-N-(9-nitroso-2-((3,3,3-trifluoropropyl)thio)-9H-purin-6-yl)nitrous amide
N-(2-(Methylthio)ethyl)-N-(9-nitroso-2-((3,3,3-trifluoropropyl)thio)-9H-purin-6-yl)nitrous amide
Catalogue No.:PA 30 0911016
CAS :
NA
Molecular Formula : C11H12F3N7O2S2
Molecular Weight : 395.38