Canrenoic Acid and its Impurities

Canrenoic Acid is a potassium-sparing diuretic and an aldosterone antagonist. It belongs to the steroidal antimineralocorticoid class of drugs. It is the active metabolite of spironolactone and potassium canrenoate, which are widely used in clinical practice. Reference standards of Canrenoic Acid API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.