Capivasertib and its Impurities
Capivasertib, sold under the brand name Truqap, is an anti-cancer medication used to treat hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer. Reference standards of Capivasertib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
4-((tert-Butoxycarbonyl)amino)-1-(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxylic Acid
4-((tert-Butoxycarbonyl)amino)-1-(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxylic Acid
Catalogue No.:PA 03 4761003
CAS :
NA
Molecular Formula : C17H22N6O5
Molecular Weight : 390.4
tert-Butyl (S)-(4-((1-(4-chlorophenyl)-3-hydroxypropyl)carbamoyl)-1-(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)carbamate
tert-Butyl (S)-(4-((1-(4-chlorophenyl)-3-hydroxypropyl)carbamoyl)-1-(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)carbamate
Catalogue No.:PA 03 4761004
CAS :
NA
Molecular Formula : C26H32ClN7O5
Molecular Weight : 558.04
(S)-4-Amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
(S)-4-Amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
Catalogue No.:PA 03 4761005
CAS :
NA
Molecular Formula : C21H24ClN7O3
Molecular Weight : 457.92
(S)-4-Amino-N-(4-((1-(4-chlorophenyl)-3-hydroxypropyl)carbamoyl)-1-(5H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
(S)-4-Amino-N-(4-((1-(4-chlorophenyl)-3-hydroxypropyl)carbamoyl)-1-(5H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
Catalogue No.:PA 03 4761006
CAS :
NA
Molecular Formula : C33H38ClN11O3
Molecular Weight : 672.19
(S)-4-Amino-4-((1-(4-chlorophenyl)-3-hydroxypropyl)carbamoyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine 1-oxide
(S)-4-Amino-4-((1-(4-chlorophenyl)-3-hydroxypropyl)carbamoyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine 1-oxide
Catalogue No.:PA 03 4761007
CAS :
NA
Molecular Formula : C21H25ClN6O3
Molecular Weight : 444.92
(S)-4-(4-Amino-4-((1-(4-chlorophenyl)-3-hydroxypropyl)carbamoyl)piperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine 3-oxide
(S)-4-(4-Amino-4-((1-(4-chlorophenyl)-3-hydroxypropyl)carbamoyl)piperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine 3-oxide
Catalogue No.:PA 03 4761008
CAS :
NA
Molecular Formula : C21H25ClN6O3
Molecular Weight : 444.92
(S)-4-(4-Amino-4-((1-(4-chlorophenyl)-3-hydroxypropyl)carbamoyl)piperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine 1-oxide
(S)-4-(4-Amino-4-((1-(4-chlorophenyl)-3-hydroxypropyl)carbamoyl)piperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine 1-oxide
Catalogue No.:PA 03 4761009
CAS :
NA
Molecular Formula : C21H25ClN6O3
Molecular Weight : 444.92
(S)-3-(4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)-3-(4-chlorophenyl)propyl 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxylate
(S)-3-(4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)-3-(4-chlorophenyl)propyl 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxylate
Catalogue No.:PA 03 4761010
CAS :
NA
Molecular Formula : C33H38ClN11O3
Molecular Weight : 672.19
(S)-1-(7H-[4,7'-Bipyrrolo[2,3-d]pyrimidin]-4'-yl)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)piperidine-4-carboxamide
(S)-1-(7H-[4,7'-Bipyrrolo[2,3-d]pyrimidin]-4'-yl)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)piperidine-4-carboxamide
Catalogue No.:PA 03 4761011
CAS :
NA
Molecular Formula : C27H28ClN9O2
Molecular Weight : 546.03
(S)-4-Amino-N-(3-hydroxy-1-phenylpropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
(S)-4-Amino-N-(3-hydroxy-1-phenylpropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
Catalogue No.:PA 03 4761012
CAS :
1143532-63-1
Molecular Formula : C21H26N6O2
Molecular Weight : 394.48
