carfilzomib and its Impurities
Carfilzomib is derived from epoxomicin, a natural product that was shown by the laboratory of Craig Crews at Yale University to inhibit the proteasome. It is an anti-cancer drug acting as a selective proteasome inhibitor. Chemically, it is a tetrapeptide epoxyketone and an analog of epoxomicin.. Reference standards of Carfilzomib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
(2R,4S)-1-((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)-4-amino-2-hydroxy-2,6-dimethylheptan-3-one
(2R,4S)-1-((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)-4-amino-2-hydroxy-2,6-dimethylheptan-3-one
Catalogue No.:PA 30 0631073
CAS :
NA
Molecular Formula : C14H21N5O3
Molecular Weight : 307.35
(S)-N-Methoxy-N,4-dimethyl-2-((S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanamido)pentanamide
(S)-N-Methoxy-N,4-dimethyl-2-((S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanamido)pentanamide
Catalogue No.:PA 30 0631074
CAS :
NA
Molecular Formula : C39H58N6O7
Molecular Weight : 722.93
(R)-4-Methyl-N-((S)-1-(((R)-4-methyl-1-((S)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((R)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide
(R)-4-Methyl-N-((S)-1-(((R)-4-methyl-1-((S)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((R)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide
Catalogue No.:PA 30 0631075
CAS :
NA
Molecular Formula : C40H57N5O7
Molecular Weight : 719.92
4-Methyl-2-(2-(2-morpholinoacetamido)-4-phenylbutanamido)-N-(1-oxo-3-phenyl-1-((1,2,2-trihydroxy-6-methyl-3-oxoheptan-4-yl)amino)propan-2-yl)pentanamide
4-Methyl-2-(2-(2-morpholinoacetamido)-4-phenylbutanamido)-N-(1-oxo-3-phenyl-1-((1,2,2-trihydroxy-6-methyl-3-oxoheptan-4-yl)amino)propan-2-yl)pentanamide
Catalogue No.:PA 30 0631077
CAS :
NA
Molecular Formula : C39H57N5O9
Molecular Weight : 739.91
4-Methyl-N-(1-((4-methyl-1-(2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-(2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide
4-Methyl-N-(1-((4-methyl-1-(2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-(2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide
Catalogue No.:PA 30 0631078
CAS :
NA
Molecular Formula : C40H57N5O7
Molecular Weight : 719.92

