cobicistat and its Impurities
Cobicistat is used to increase the amounts of atazanavir or darunavir in the blood when these medications are used to treat human immunodeficiency virus. Cobicistat, with trade name Tybost. Reference standards of Cobicistat API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


4-((S)-4-(((2R,5R)-1,6-Diphenyl-5-(((thiazol-5-ylmethoxy)carbonyl)amino)hexan-2-yl)amino)-3-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-oxobutyl)morpholine 4-Oxide
4-((S)-4-(((2R,5R)-1,6-Diphenyl-5-(((thiazol-5-ylmethoxy)carbonyl)amino)hexan-2-yl)amino)-3-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-oxobutyl)morpholine 4-Oxide
Catalogue No.:PA 56 91510
CAS :
1992785-27-9
Molecular Formula : C40H53N7O6S2
Molecular Weight : 792.03


(S)-N-((2R,5R)-5-Amino-1,6-diphenylhexan-2-yl)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanamide
(S)-N-((2R,5R)-5-Amino-1,6-diphenylhexan-2-yl)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanamide
Catalogue No.:PA 56 0911002
CAS :
NA
Molecular Formula : C35H50N6O3S
Molecular Weight : 634.88


(S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-N-((2R,5R)-5-((R)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanamido)-1,6-diphenylhexan-2-yl)-4-morpholinobutanamide
(S)-2-(3-((2-Isopropylthiazol-4-yl)methyl)-3-methylureido)-N-((2R,5R)-5-((R)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanamido)-1,6-diphenylhexan-2-yl)-4-morpholinobutanamide
Catalogue No.:PA 56 0911003
CAS :
NA
Molecular Formula : C52H76N10O6S2
Molecular Weight : 1001.36


Thiazol-5-ylmethyl ((2S,5S)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanamido)-1,6-diphenylhexan-2-yl)carbamate
Thiazol-5-ylmethyl ((2S,5S)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanamido)-1,6-diphenylhexan-2-yl)carbamate
Catalogue No.:PA 56 0911005
CAS :
NA
Molecular Formula : C40H53N7O5S2
Molecular Weight : 776.03


Thiazol-5-ylmethyl ((2S,5S)-5-((R)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanamido)-1,6-diphenylhexan-2-yl)carbamate
Thiazol-5-ylmethyl ((2S,5S)-5-((R)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanamido)-1,6-diphenylhexan-2-yl)carbamate
Catalogue No.:PA 56 0911007
CAS :
NA
Molecular Formula : C40H53N7O5S2
Molecular Weight : 776.03


Thiazol-5-ylmethyl ((2R,5R)-5-((S)-2-(3-(2-isopropylthiazole-4-carbonyl)-3-methylureido)-4-morpholinobutanamido)-1,6-diphenylhexan-2-yl)carbamate
Thiazol-5-ylmethyl ((2R,5R)-5-((S)-2-(3-(2-isopropylthiazole-4-carbonyl)-3-methylureido)-4-morpholinobutanamido)-1,6-diphenylhexan-2-yl)carbamate
Catalogue No.:PA 56 0911010
CAS :
NA
Molecular Formula : C40H51N7O6S2
Molecular Weight : 790.01


Thiazol-5-ylmethyl ((2R,5R)-5-(2-amino-4-morpholinobutanamido)-1,6-diphenylhexan-2-yl)carbamate trihydrochloride
Thiazol-5-ylmethyl ((2R,5R)-5-(2-amino-4-morpholinobutanamido)-1,6-diphenylhexan-2-yl)carbamate trihydrochloride
Catalogue No.:PA 56 0911013
CAS :
NA
Molecular Formula : C31H44Cl3N5O4S
Molecular Weight : 689.13


Thiazol-5-ylmethyl ((2R,5R)-5-(2-(3-((2-(2-hydroxypropan-2-yl)thiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanamido)-1,6-diphenylhexan-2-yl)carbamate
Thiazol-5-ylmethyl ((2R,5R)-5-(2-(3-((2-(2-hydroxypropan-2-yl)thiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanamido)-1,6-diphenylhexan-2-yl)carbamate
Catalogue No.:PA 56 0911014
CAS :
NA
Molecular Formula : C40H53N7O6S2
Molecular Weight : 792.03


Thiazol-5-Ylmethyl ((2R,5R)-5-((S)-2-Amino-4-morpholinobutanamido)-1,6-diphenylhexan-2-yl)Carbamate
Thiazol-5-Ylmethyl ((2R,5R)-5-((S)-2-Amino-4-morpholinobutanamido)-1,6-diphenylhexan-2-yl)Carbamate
Catalogue No.:PA 56 0911016
CAS :
1051463-15-0
Molecular Formula : C31H41N5O4S
Molecular Weight : 579.76


(S)-Ethyl 2-[3-(2-Isopropyl-thiazol-4-ylmethyl)-3-methylureido]-4-morpholin-4-yl-butanoate
(S)-Ethyl 2-[3-(2-Isopropyl-thiazol-4-ylmethyl)-3-methylureido]-4-morpholin-4-yl-butanoate
Catalogue No.:PA 56 0911017
CAS :
1247119-35-2
Molecular Formula : C19H32N4O4S
Molecular Weight : 412.55


Isopropyl ((S)-(((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
Isopropyl ((S)-(((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
Catalogue No.:PA 56 0911018
CAS :
1689524-82-0
Molecular Formula : C29H34FN4O9P
Molecular Weight : 632.58


Ethyl (S)-2-(((2-isopropylthiazol-4-yl)methyl)(methyl)amino)-5,6-dihydro-4H-1,3-oxazine-4-carboxylate
Ethyl (S)-2-(((2-isopropylthiazol-4-yl)methyl)(methyl)amino)-5,6-dihydro-4H-1,3-oxazine-4-carboxylate
Catalogue No.:PA 56 0911024
CAS :
NA
Molecular Formula : C15H23N3O3S
Molecular Weight : 325.43


(S)-4-Ethoxy-3-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-oxobutyl (S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate
(S)-4-Ethoxy-3-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-oxobutyl (S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate
Catalogue No.:PA 56 0911025
CAS :
NA
Molecular Formula : C32H51N7O7S2
Molecular Weight : 709.92