dabrafenib and its Impurities
Dabrafenib is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It is used alone or in combination with another medication to treat a type of skin cancer.. Reference standards of Dabrafenib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below


2-Amino-N-(3-(5-(2-aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-6-fluorobenzenesulfonamide
2-Amino-N-(3-(5-(2-aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-6-fluorobenzenesulfonamide
Catalogue No.:PA 31 0061000
CAS :
2017554-98-0
Molecular Formula : C23H22F2N6O2S2
Molecular Weight : 516.59


N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2-fluoro-6-methoxybenzenesulfonamide
N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2-fluoro-6-methoxybenzenesulfonamide
Catalogue No.:PA 31 0061012
CAS :
NA
Molecular Formula : C24H23F2N5O3S2
Molecular Weight : 531.6


N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)phenyl)-2,6-difluorobenzenesulfonamide
N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)phenyl)-2,6-difluorobenzenesulfonamide
Catalogue No.:PA 31 0061015
CAS :
NA
Molecular Formula : C23H21F2N5O2S2
Molecular Weight : 501.57


N-(3-(2-(Tert-butyl)-5-(2-(dimethylamino)pyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
N-(3-(2-(Tert-butyl)-5-(2-(dimethylamino)pyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
Catalogue No.:PA 31 0061016
CAS :
NA
Molecular Formula : C25H24F3N5O2S2
Molecular Weight : 547.62


1-(2-chloropyrimidin-4-yl)-2-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)-2-oxoethyl 2,2-dimethylpropanimidothioate
1-(2-chloropyrimidin-4-yl)-2-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)-2-oxoethyl 2,2-dimethylpropanimidothioate
Catalogue No.:PA 31 0061020
CAS :
NA
Molecular Formula : C23H20ClF3N4O3S2
Molecular Weight : 557


N-(3-(2-(tert-Butyl)-5-(2-hydroxypyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
N-(3-(2-(tert-Butyl)-5-(2-hydroxypyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
Catalogue No.:PA 31 0061022
CAS :
NA
Molecular Formula : C23H19F3N4O3S2
Molecular Weight : 520.55


N-(3-(2-(tert-Butyl)-4-hydroxy-5-(2-hydroxypyrimidin-4-yl)-4,5-dihydrothiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
N-(3-(2-(tert-Butyl)-4-hydroxy-5-(2-hydroxypyrimidin-4-yl)-4,5-dihydrothiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
Catalogue No.:PA 31 0061025
CAS :
NA
Molecular Formula : C23H21F3N4O4S2
Molecular Weight : 538.56


N-(3-(2-(Tert-butyl)-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
N-(3-(2-(Tert-butyl)-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
Catalogue No.:PA 31 0061026
CAS :
1195768-23-0
Molecular Formula : C23H18ClF3N4O2S2
Molecular Weight : 538.99


5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)-4-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)thiazole 3-oxide
5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)-4-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)thiazole 3-oxide
Catalogue No.:PA 31 0061031
CAS :
NA
Molecular Formula : C23H20F3N5O3S2
Molecular Weight : 535.56


2-Amino-4-(2-(tert-butyl)-4-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)thiazol-5-yl)pyrimidine 1-oxide
2-Amino-4-(2-(tert-butyl)-4-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)thiazol-5-yl)pyrimidine 1-oxide
Catalogue No.:PA 31 0061032
CAS :
NA
Molecular Formula : C23H20F3N5O3S2
Molecular Weight : 535.56


N-(3-(2-(2-Chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-N-((2,6-difluorophenyl)sulfonyl)-2,6-difluorobenzenesulfonamide
N-(3-(2-(2-Chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-N-((2,6-difluorophenyl)sulfonyl)-2,6-difluorobenzenesulfonamide
Catalogue No.:PA 31 0061036
CAS :
NA
Molecular Formula : C24H13ClF5N3O5S2
Molecular Weight : 617.95