Daprodustat and its Impurities
Daprodustat, sold under the brand name Duvroq among others, is a medication that is used for the treatment of anemia due to chronic kidney disease. Reference standards of Daprodustat API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


Ethyl (1,3-dicyclohexyl-5-((2-ethoxy-2-oxoethyl)amino)-2,4,6-trioxohexahydropyrimidine-5-carbonyl)glycinate
Ethyl (1,3-dicyclohexyl-5-((2-ethoxy-2-oxoethyl)amino)-2,4,6-trioxohexahydropyrimidine-5-carbonyl)glycinate
Catalogue No.:PA 04 2861007
CAS :
NA
Molecular Formula : C25H38N4O8
Molecular Weight : 522.6


Diethyl 2,2'-((1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5,5-dicarbonyl)bis(azanediyl))diacetate
Diethyl 2,2'-((1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5,5-dicarbonyl)bis(azanediyl))diacetate
Catalogue No.:PA 04 2861017
CAS :
NA
Molecular Formula : C26H38N4O9
Molecular Weight : 550.61


2,2'-((1,3-Dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5,5-dicarbonyl)bis(azanediyl))diacetic Acid
2,2'-((1,3-Dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5,5-dicarbonyl)bis(azanediyl))diacetic Acid
Catalogue No.:PA 04 2861018
CAS :
NA
Molecular Formula : C22H30N4O9
Molecular Weight : 494.5


(4-Hydroxy-1,3-bis((1r,4R)-4-hydroxycyclohexyl)-2,6-dioxohexahydropyrimidine-5-carbonyl)glycine
(4-Hydroxy-1,3-bis((1r,4R)-4-hydroxycyclohexyl)-2,6-dioxohexahydropyrimidine-5-carbonyl)glycine
Catalogue No.:PA 04 2861020
CAS :
NA
Molecular Formula : C19H29N3O8
Molecular Weight : 427.45


(4-Hydroxy-1-((1S,3S)-3-hydroxycyclohexyl)-3-((1r,4S)-4-hydroxycyclohexyl)-2,6-dioxohexahydropyrimidine-5-carbonyl)glycine
(4-Hydroxy-1-((1S,3S)-3-hydroxycyclohexyl)-3-((1r,4S)-4-hydroxycyclohexyl)-2,6-dioxohexahydropyrimidine-5-carbonyl)glycine
Catalogue No.:PA 04 2861021
CAS :
NA
Molecular Formula : C19H29N3O8
Molecular Weight : 427.45


1,3-Dicyclohexyl-N-(2-(1,3-dicyclohexyl-2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)-2-hydroxyethyl)-2,4,6-trioxohexahydropyrimidine-5-carboxamide
1,3-Dicyclohexyl-N-(2-(1,3-dicyclohexyl-2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)-2-hydroxyethyl)-2,4,6-trioxohexahydropyrimidine-5-carboxamide
Catalogue No.:PA 04 2861023
CAS :
NA
Molecular Formula : C35H49N5O8
Molecular Weight : 667.8