darunavir and its Impurities
A second-generation protease inhibitor, it is used for the treatment of HIV infections. It is administered along with ritonavir or cobicistat, to decrease metabolism and increase concentration.. Reference standards of Darunavir API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below


[(1S,2R)-1-Benzyl-2-hydroxy-3-[isobutyl-[(4-aminophenyl)sulfonyl]amino] propyl]carbamic Acid tert-Butyl Ester
[(1S,2R)-1-Benzyl-2-hydroxy-3-[isobutyl-[(4-aminophenyl)sulfonyl]amino] propyl]carbamic Acid tert-Butyl Ester
Catalogue No.:PA 04 06510
CAS :
183004-94-6
Molecular Formula : C25H37N3O5S
Molecular Weight : 491.64

![(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl-4-(N-( PA 04 06540](https://www.pharmaffiliates.com/pimages/PA0406540.jpg)
(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl-4-(N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylsulfamoyl)phenylcarbamate
(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl-4-(N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylsulfamoyl)phenylcarbamate
Catalogue No.:PA 04 06540
CAS :
NA
Molecular Formula : C27H37N3O7S
Molecular Weight : 547.66


Benzyl (2S,3R)-4-(4-(3-((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydrxy-1-phenylbutan-2-yl)ureido)-N-isobutylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
Benzyl (2S,3R)-4-(4-(3-((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydrxy-1-phenylbutan-2-yl)ureido)-N-isobutylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
Catalogue No.:PA 04 06610
CAS :
NA
Molecular Formula : C43H58N6O9S2
Molecular Weight : 867.09


[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-Carbamic Acid Phenylmethyl Ester
[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-Carbamic Acid Phenylmethyl Ester
Catalogue No.:PA 04 06620
CAS :
159005-61-5
Molecular Formula : C28H35N3O5S
Molecular Weight : 525.66


((2S,3R)-4-(4-(((((3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl)oxy)carbonyl)amino)-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamic Acid Phenylmethyl Ester
((2S,3R)-4-(4-(((((3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl)oxy)carbonyl)amino)-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamic Acid Phenylmethyl Ester
Catalogue No.:PA 04 06630
CAS :
NA
Molecular Formula : C35H43N3O9S
Molecular Weight : 681.8


4-Amino-N-(2-methylpropyl)-N-[[(4S,5R)-2-oxo-4-(phenylmethyl)-5-oxazolidinyl]methyl]-benzenesulfonamide
4-Amino-N-(2-methylpropyl)-N-[[(4S,5R)-2-oxo-4-(phenylmethyl)-5-oxazolidinyl]methyl]-benzenesulfonamide
Catalogue No.:PA 04 06670
CAS :
1418639-27-6
Molecular Formula : C21H27N3O4S
Molecular Weight : 417.52


[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenyl-methyl)propyl]carabamic Acid Methyl Ester
[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenyl-methyl)propyl]carabamic Acid Methyl Ester
Catalogue No.:PA 04 06680
CAS :
1526916-57-3
Molecular Formula : C22H31N3O5S
Molecular Weight : 449.56

![(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3 PA 04 06690](https://www.pharmaffiliates.com/pimages/PA0406690.jpg)
(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-(4-(3-((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)-1-isobutylureido)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-(4-(3-((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)-1-isobutylureido)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
Catalogue No.:PA 04 06690
CAS :
NA
Molecular Formula : C48H64N6O11S2
Molecular Weight : 965.19


Benzyl ((2S,3R)-4-((4-(3-((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)ureido)-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
Benzyl ((2S,3R)-4-((4-(3-((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)ureido)-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
Catalogue No.:PA 04 06830
CAS :
NA
Molecular Formula : C49H62N6O9S2
Molecular Weight : 943.19


N-[(1R,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic Acid 1,1-Dimethylethyl Ester
N-[(1R,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic Acid 1,1-Dimethylethyl Ester
Catalogue No.:PA 04 0061002
CAS :
1005324-46-8
Molecular Formula : C25H35N3O7S
Molecular Weight : 521.63

![(3R,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3 PA 04 0061003](https://www.pharmaffiliates.com/pimages/PA040061003.jpg)
(3R,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate compound with Ethanol (1:1)
(3R,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate compound with Ethanol (1:1)
Catalogue No.:PA 04 0061003
CAS :
NA
Molecular Formula : C29H43N3O8S
Molecular Weight : 593.74

![(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3 PA 04 06750](https://www.pharmaffiliates.com/pimages/PA0406750.jpg)
(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3S)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3S)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
Catalogue No.:PA 04 06750
CAS :
850141-19-4
Molecular Formula : C27H37N3O7S
Molecular Weight : 547.67


(2R,3S)-3-Amino-1-((4-amino-N-isobutylphenyl)sulfonamido)-4-phenylbutan-2-yl ((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl) Carbonate
(2R,3S)-3-Amino-1-((4-amino-N-isobutylphenyl)sulfonamido)-4-phenylbutan-2-yl ((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl) Carbonate
Catalogue No.:PA 04 06770
CAS :
NA
Molecular Formula : C27H37N3O7S
Molecular Weight : 547.67


N-[(1S,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic Acid 1,1-Dimethylethyl Ester
N-[(1S,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic Acid 1,1-Dimethylethyl Ester
Catalogue No.:PA 04 0061009
CAS :
1133153-38-4
Molecular Formula : C25H35N3O7S
Molecular Weight : 521.63

![(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3 PA 04 0061010](https://www.pharmaffiliates.com/pimages/PA040061010.jpg)
(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-(((((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl)oxy)carbonyl)oxy)-1-phenylbutan-2-yl)carbamate
(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-(((((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl)oxy)carbonyl)oxy)-1-phenylbutan-2-yl)carbamate
Catalogue No.:PA 04 0061010
CAS :
1291087-81-4
Molecular Formula : C34H45N3O11S
Molecular Weight : 703.8


Tert-butyl ((2S,3R)-4-(4-acetamido-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
Tert-butyl ((2S,3R)-4-(4-acetamido-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
Catalogue No.:PA 04 0061011
CAS :
160230-47-7
Molecular Formula : C27H39N3O6S
Molecular Weight : 533.68


N-((2R,3S)-3-Amino-2-hydroxy-4-phenylbutyl)-n-isobutyl-4-nitrobenzene-1-sulfonamide Hydrochloride
N-((2R,3S)-3-Amino-2-hydroxy-4-phenylbutyl)-n-isobutyl-4-nitrobenzene-1-sulfonamide Hydrochloride
Catalogue No.:PA 04 0061014
CAS :
244634-31-9
Molecular Formula : C20H28ClN3O5S
Molecular Weight : 457.97


N-[(1S,2R)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic acid (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl ester
N-[(1S,2R)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic acid (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl ester
Catalogue No.:PA 04 0061016
CAS :
799241-76-2
Molecular Formula : C27H35N3O9S
Molecular Weight : 577.65

![(3R,3aS,6aS)-Hexahydrofuro[2,3-b]furan-3-yl (4-(N- PA 04 0061017](https://www.pharmaffiliates.com/pimages/PA040061017.jpg)
(3R,3aS,6aS)-Hexahydrofuro[2,3-b]furan-3-yl (4-(N-((2R,3S)-3-(((((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl)oxy)carbonyl)amino)-2-hydroxy-4-phenylbutyl)-N-isobutylsulfamoyl)phenyl)carbamate
(3R,3aS,6aS)-Hexahydrofuro[2,3-b]furan-3-yl (4-(N-((2R,3S)-3-(((((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl)oxy)carbonyl)amino)-2-hydroxy-4-phenylbutyl)-N-isobutylsulfamoyl)phenyl)carbamate
Catalogue No.:PA 04 0061017
CAS :
1971057-59-6
Molecular Formula : C34H45N3O11S
Molecular Weight : 703.8

![(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3 PA 04 0061018](https://www.pharmaffiliates.com/pimages/PA040061018.jpg)
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-((4-amino-N-(2-hydroxy-2-methylpropyl)phenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-((4-amino-N-(2-hydroxy-2-methylpropyl)phenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
Catalogue No.:PA 04 0061018
CAS :
1809154-88-8
Molecular Formula : C27H37N3O8S
Molecular Weight : 563.67

![(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3 PA 04 0061019](https://www.pharmaffiliates.com/pimages/PA040061019.jpg)
(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-((4-amino-3-hydroxy-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-((4-amino-3-hydroxy-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
Catalogue No.:PA 04 0061019
CAS :
1159613-24-7
Molecular Formula : C27H37N3O8S
Molecular Weight : 563.67

![(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3 PA 04 0061023](https://www.pharmaffiliates.com/pimages/PA040061023.jpg)
(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-3-hydroxy-4-((4-(isobutyl(methyl)amino)phenyl)sulfonamido)-1-phenylbutan-2-yl)carbamate
(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-3-hydroxy-4-((4-(isobutyl(methyl)amino)phenyl)sulfonamido)-1-phenylbutan-2-yl)carbamate
Catalogue No.:PA 04 0061023
CAS :
NA
Molecular Formula : C28H39N3O7S
Molecular Weight : 561.69

![(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3 PA 04 0061024](https://www.pharmaffiliates.com/pimages/PA040061024.jpg)
(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-3-chloro-4-((4-(isobutylamino)phenyl)sulfonamido)-1-phenylbutan-2-yl)carbamate
(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-3-chloro-4-((4-(isobutylamino)phenyl)sulfonamido)-1-phenylbutan-2-yl)carbamate
Catalogue No.:PA 04 0061024
CAS :
1005324-06-0
Molecular Formula : C27H36ClN3O6S
Molecular Weight : 566.11

![(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3 PA 04 0061027](https://www.pharmaffiliates.com/pimages/PA040061027.jpg)
(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-((4-acetamido-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-((4-acetamido-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
Catalogue No.:PA 04 0061027
CAS :
1546919-11-2
Molecular Formula : C29H39N3O8S
Molecular Weight : 589.7


tert-Butyl ((2S,3S)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
tert-Butyl ((2S,3S)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
Catalogue No.:PA 04 0061030
CAS :
NA
Molecular Formula : C25H37N3O5S
Molecular Weight : 491.65


tert-Butyl ((2R,3S)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
tert-Butyl ((2R,3S)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
Catalogue No.:PA 04 0061031
CAS :
NA
Molecular Formula : C25H37N3O5S
Molecular Weight : 491.65


rel-Tert-butyl ((2R,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
rel-Tert-butyl ((2R,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
Catalogue No.:PA 04 0061033
CAS :
2124272-21-3
Molecular Formula : C25H37N3O5S
Molecular Weight : 491.65

ami PA 04 0061034](https://www.pharmaffiliates.com/pimages/PA040061034.jpg)
[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](n-propyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl- ester
[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](n-propyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl- ester
Catalogue No.:PA 04 0061034
CAS :
NA
Molecular Formula : C26H35N3O7S
Molecular Weight : 533.64


Di-tert-butyl ((2S,2'S,3R,3'R)-(isobutylazanediyl)bis(3-hydroxy-1-phenylbutane-4,2-diyl))dicarbamate
Di-tert-butyl ((2S,2'S,3R,3'R)-(isobutylazanediyl)bis(3-hydroxy-1-phenylbutane-4,2-diyl))dicarbamate
Catalogue No.:PA 04 0061035
CAS :
2307745-62-4
Molecular Formula : C34H53N3O6
Molecular Weight : 599.81