dasatinib and its Impurities
A Bcr-Abl tyrosine kinase inhibitor, Dasatinib is an anti cancer drug. It is administered orally and used for the treatment of prostrate cancer and many other cancers. It is a Src family tyrosine kinase inhibitor used for treating leukemia.. Reference standards of Dasatinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below


N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
Catalogue No.:PA 04 07550
CAS :
302964-08-5
Molecular Formula : C16H13Cl2N5OS
Molecular Weight : 394.28


2,2-Dimethyl-propanoic Acid [2-[[(2-Amino-5-thiazolyl)carbonyl]amino]-3-chlorophenyl]methyl Ester
2,2-Dimethyl-propanoic Acid [2-[[(2-Amino-5-thiazolyl)carbonyl]amino]-3-chlorophenyl]methyl Ester
Catalogue No.:PA 04 07640
CAS :
910297-69-7
Molecular Formula : C16H18ClN3O3S
Molecular Weight : 367.85


2,2-Dimethyl-propanoic Acid [3-Chloro-2-[[[2-[(triphenylmethyl)amino]-5-thiazolyl]carbonyl]amino]phenyl]methyl Ester
2,2-Dimethyl-propanoic Acid [3-Chloro-2-[[[2-[(triphenylmethyl)amino]-5-thiazolyl]carbonyl]amino]phenyl]methyl Ester
Catalogue No.:PA 04 07650
CAS :
910298-41-8
Molecular Formula : C35H32ClN3O3S
Molecular Weight : 610.16


N-(2-chloro-6-methylphenyl)-2-((6-((2-hydroxyethyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-((6-((2-hydroxyethyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
Catalogue No.:PA 04 0071001
CAS :
302962-47-6
Molecular Formula : C18H19ClN6O2S
Molecular Weight : 418.9


2-(4-(6-((5-((2-Chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)piperazin-1-yl)ethyl acetate
2-(4-(6-((5-((2-Chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)piperazin-1-yl)ethyl acetate
Catalogue No.:PA 04 0071003
CAS :
1245157-85-0
Molecular Formula : C24H28ClN7O3S
Molecular Weight : 530.04


N-(2-Chloro-6-methylphenyl)-2-((6-((2-((2-hydroxyethyl)amino)ethyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
N-(2-Chloro-6-methylphenyl)-2-((6-((2-((2-hydroxyethyl)amino)ethyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
Catalogue No.:PA 04 0071004
CAS :
1025814-13-4
Molecular Formula : C20H24ClN7O2S
Molecular Weight : 461.97


N-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl-1,1,2,2-d4)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
N-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl-1,1,2,2-d4)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
Catalogue No.:PA 04 0071005
CAS :
1160297-08-4
Molecular Formula : C22H22D4ClN7O2S
Molecular Weight : 492.03


N-(2-Chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin-4-yl)amino)thiazole-5-carboxamide hydrochloride
N-(2-Chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin-4-yl)amino)thiazole-5-carboxamide hydrochloride
Catalogue No.:PA 04 0071006
CAS :
1852573-26-2
Molecular Formula : C20H23Cl2N7OS
Molecular Weight : 480.41


N-(2,4-Dichloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)-2-methylpiperazin-1-yl)pyrimidin-4-yl)amino)thiazole-5-carboxamide
N-(2,4-Dichloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)-2-methylpiperazin-1-yl)pyrimidin-4-yl)amino)thiazole-5-carboxamide
Catalogue No.:PA 04 0071007
CAS :
NA
Molecular Formula : C22H25Cl2N7O2S
Molecular Weight : 522.45


2,2'-((2-Methylpyrimidine-4,6-diyl)bis(azanediyl))bis(N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide)
2,2'-((2-Methylpyrimidine-4,6-diyl)bis(azanediyl))bis(N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide)
Catalogue No.:PA 04 0071008
CAS :
2468737-80-4
Molecular Formula : C27H22Cl2N8O2S2
Molecular Weight : 625.55


2-Amino-N-(6-chloro-2-methylpyrimidin-4-yl)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
2-Amino-N-(6-chloro-2-methylpyrimidin-4-yl)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Catalogue No.:PA 04 0071009
CAS :
2468737-81-5
Molecular Formula : C16H13Cl2N5OS
Molecular Weight : 394.27


2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-methyl-6-(2-(piperazin-1-yl)ethoxy)phenyl)thiazole-5-carboxamide
2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-methyl-6-(2-(piperazin-1-yl)ethoxy)phenyl)thiazole-5-carboxamide
Catalogue No.:PA 04 0071010
CAS :
2468737-82-6
Molecular Formula : C22H26ClN7O2S
Molecular Weight : 488.01


N-(2-Chloro-6-methylphenyl)-2-((2-methyl-6-(2-(piperazin-1-yl)ethoxy)pyrimidin-4-yl)amino)thiazole-5-carboxamide
N-(2-Chloro-6-methylphenyl)-2-((2-methyl-6-(2-(piperazin-1-yl)ethoxy)pyrimidin-4-yl)amino)thiazole-5-carboxamide
Catalogue No.:PA 04 0071011
CAS :
2468737-83-7
Molecular Formula : C22H26ClN7O2S
Molecular Weight : 488.01


N-(2-Methyl-6-(2-(piperazin-1-yl)ethoxy)phenyl)-2-((2-methyl-6-(2-(piperazin-1-yl)ethoxy)pyrimidin-4-yl)amino)thiazole-5-carboxamide
N-(2-Methyl-6-(2-(piperazin-1-yl)ethoxy)phenyl)-2-((2-methyl-6-(2-(piperazin-1-yl)ethoxy)pyrimidin-4-yl)amino)thiazole-5-carboxamide
Catalogue No.:PA 04 0071012
CAS :
2468737-84-8
Molecular Formula : C28H39N9O3S
Molecular Weight : 581.74


2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-(4-(2-hydroxyethyl)piperazin-1-yl)-6-methylphenyl)thiazole-5-carboxamide
2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-(4-(2-hydroxyethyl)piperazin-1-yl)-6-methylphenyl)thiazole-5-carboxamide
Catalogue No.:PA 04 0071013
CAS :
2048106-50-7
Molecular Formula : C22H26ClN7O2S
Molecular Weight : 488.01


2-((6-(4-(2-Hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-N-(2-(4-(2-hydroxyethyl)piperazin-1-yl)-6-methylphenyl)thiazole-5-carboxamide
2-((6-(4-(2-Hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-N-(2-(4-(2-hydroxyethyl)piperazin-1-yl)-6-methylphenyl)thiazole-5-carboxamide
Catalogue No.:PA 04 0071014
CAS :
2468737-87-1
Molecular Formula : C28H39N9O3S
Molecular Weight : 581.74


1-(6-((5-((2-Chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)-4-(2-hydroxyethyl)piperazine 1-oxide
1-(6-((5-((2-Chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)-4-(2-hydroxyethyl)piperazine 1-oxide
Catalogue No.:PA 04 0071016
CAS :
2468737-88-2
Molecular Formula : C22H26ClN7O3S
Molecular Weight : 504.01


1-(6-((5-((2-Chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)-4-(2-hydroxyethyl)piperazine 1,4-dioxide
1-(6-((5-((2-Chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)-4-(2-hydroxyethyl)piperazine 1,4-dioxide
Catalogue No.:PA 04 0071017
CAS :
910297-56-2
Molecular Formula : C22H26ClN7O4S
Molecular Weight : 520.01


(2S,3S,4S,5R,6R)-6-(2-(4-(6-((5-((2-Chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)piperazin-1-yl)ethoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
(2S,3S,4S,5R,6R)-6-(2-(4-(6-((5-((2-Chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)piperazin-1-yl)ethoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
Catalogue No.:PA 04 0071018
CAS :
1860069-15-3
Molecular Formula : C28H34ClN7O8S
Molecular Weight : 664.13


N-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)(nitroso)amino)thiazole-5-carboxamide
N-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)(nitroso)amino)thiazole-5-carboxamide
Catalogue No.:PA 04 0071022
CAS :
NA
Molecular Formula : C22H25ClN8O3S
Molecular Weight : 517.01


N1-(2-Chloro-6-methylphenyl)-N2-(5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)oxalamide
N1-(2-Chloro-6-methylphenyl)-N2-(5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)oxalamide
Catalogue No.:PA 04 0071024
CAS :
NA
Molecular Formula : C20H16Cl2N4O3S
Molecular Weight : 463.33


4-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)amino)-4-oxo-1-(piperidin-1-yl)butane-2-sulfonic Acid
4-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)amino)-4-oxo-1-(piperidin-1-yl)butane-2-sulfonic Acid
Catalogue No.:PA 04 0071026
CAS :
2641759-50-2
Molecular Formula : C24H27ClFN5O5S
Molecular Weight : 552.02


2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxylic acid
2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxylic acid
Catalogue No.:PA 04 0071028
CAS :
1245157-42-9
Molecular Formula : C15H20N6O3S
Molecular Weight : 364.42


2-(Bis(6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
2-(Bis(6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Catalogue No.:PA 04 0071027
CAS :
1180525-74-9
Molecular Formula : C21H16Cl3N7OS
Molecular Weight : 520.82


N-(6-Chloro-2-methylpyrimidin-4-yl)-2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
N-(6-Chloro-2-methylpyrimidin-4-yl)-2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Catalogue No.:PA 04 0071029
CAS :
1417651-54-7
Molecular Formula : C21H16Cl3N7OS
Molecular Weight : 520.82


2-((6-Chloro-2-methylpyrimidin-4-yl)(nitroso)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
2-((6-Chloro-2-methylpyrimidin-4-yl)(nitroso)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Catalogue No.:PA 04 0071030
CAS :
NA
Molecular Formula : C16H12Cl2N6O2S
Molecular Weight : 423.27