Difelikefalin and its Impurities
Difelikefalin, sold under the brand name Korsuva, is an analgesic opioid peptide used for the treatment of moderate to severe itching. Reference standards of Difelikefalin API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


1-(N2-D-phenylalanyl-D-phenylalanyl-D-leucyl-N6-acetyl-D-lysyl)-4-aminopiperidine-4-carboxylic acid
1-(N2-D-phenylalanyl-D-phenylalanyl-D-leucyl-N6-acetyl-D-lysyl)-4-aminopiperidine-4-carboxylic acid
Catalogue No.:PA PEP 001133
CAS :
NA
Molecular Formula : C38H55N7O7
Molecular Weight : 721.9


1-(N2-D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-acetyl-D-lysyl)-4-acetamidopiperidine-4-carboxylic Acid
1-(N2-D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-acetyl-D-lysyl)-4-acetamidopiperidine-4-carboxylic Acid
Catalogue No.:PA PEP 001136
CAS :
NA
Molecular Formula : C40H57N7O8
Molecular Weight : 763.94


1-(N6-Acetyl-N2-acetyl-D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-aminopiperidine-4-carboxylic Acid
1-(N6-Acetyl-N2-acetyl-D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-aminopiperidine-4-carboxylic Acid
Catalogue No.:PA PEP 001137
CAS :
NA
Molecular Formula : C40H57N7O8
Molecular Weight : 763.94


4-Acetamido-1-(acetyl-D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)piperidine-4-carboxylic Acid
4-Acetamido-1-(acetyl-D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)piperidine-4-carboxylic Acid
Catalogue No.:PA PEP 001138
CAS :
NA
Molecular Formula : C40H57N7O8
Molecular Weight : 763.94


4-Acetamido-1-(N6-acetyl-N2-acetyl-D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)piperidine-4-carboxylic Acid
4-Acetamido-1-(N6-acetyl-N2-acetyl-D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)piperidine-4-carboxylic Acid
Catalogue No.:PA PEP 001139
CAS :
NA
Molecular Formula : C42H59N7O9
Molecular Weight : 805.97


4-Amino-1-((R)-2-((R)-2-((R)-2-((R)-2-amino-3-phenylpropanamido)-3-phenylpropanamido)-4-methylpentanamido)-6-oxohexanoyl)piperidine-4-carboxylic Acid
4-Amino-1-((R)-2-((R)-2-((R)-2-((R)-2-amino-3-phenylpropanamido)-3-phenylpropanamido)-4-methylpentanamido)-6-oxohexanoyl)piperidine-4-carboxylic Acid
Catalogue No.:PA PEP 001140
CAS :
NA
Molecular Formula : C36H50N6O7
Molecular Weight : 678.83


4-Amino-1-((R)-2-((R)-2-((R)-2-((R)-2-amino-3-phenylpropanamido)-3-phenylpropanamido)-4-methylpentanamido)-5-carboxypentanoyl)piperidine-4-carboxylic Acid
4-Amino-1-((R)-2-((R)-2-((R)-2-((R)-2-amino-3-phenylpropanamido)-3-phenylpropanamido)-4-methylpentanamido)-5-carboxypentanoyl)piperidine-4-carboxylic Acid
Catalogue No.:PA PEP 001141
CAS :
NA
Molecular Formula : C36H50N6O8
Molecular Weight : 694.83


1-(N2-D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-(1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-aminopiperidine-4-carbonyl)-D-lysyl)-4-aminopiperidine-4-carboxylic Acid
1-(N2-D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-(1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-aminopiperidine-4-carbonyl)-D-lysyl)-4-aminopiperidine-4-carboxylic Acid
Catalogue No.:PA PEP 001150
CAS :
NA
Molecular Formula : C72H104N14O11
Molecular Weight : 1341.71


1-(D-Phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-(1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-aminopiperidine-4-carboxamido)piperidine-4-carboxylic Acid
1-(D-Phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-(1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-aminopiperidine-4-carboxamido)piperidine-4-carboxylic Acid
Catalogue No.:PA PEP 001151
CAS :
NA
Molecular Formula : C72H104N14O11
Molecular Weight : 1341.71


1-(N2-D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-(1-(N2-D-phenylalanyl-D-phenylalanyl-D-leucyl-N6-(1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-aminopiperidine-4-carbonyl)-D-lysyl)-4-aminopiperidine-4-carbonyl)-D-lysyl)-4-aminopiperidine-4-carboxylic Acid
1-(N2-D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-(1-(N2-D-phenylalanyl-D-phenylalanyl-D-leucyl-N6-(1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-aminopiperidine-4-carbonyl)-D-lysyl)-4-aminopiperidine-4-carbonyl)-D-lysyl)-4-aminopiperidine-4-carboxylic Acid
Catalogue No.:PA PEP 001152
CAS :
NA
Molecular Formula : C108H155N21O16
Molecular Weight : 2003.56