domperidone and its Impurities
A selective dopamine D2 and D3 receptor antagonist, Domperidone is used for the treatment of nausea, vomiting, gastroparesis, Parkinson's disease, as a lactation stimulant. It is administered orally or rectally.. Reference standards of Domperidone API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
5-Chloro-3-methylthiomethyl-1-[1-[3-(2-oxo-1-benzimidazolinyl)propyl]-4-piperidyl]-2-benzimidazolinone
5-Chloro-3-methylthiomethyl-1-[1-[3-(2-oxo-1-benzimidazolinyl)propyl]-4-piperidyl]-2-benzimidazolinone
Catalogue No.:PA 04 38560
CAS :
NA
Molecular Formula : C24H28ClN5O2S
Molecular Weight : 486.03
1,1'-[(1,3-dihydro-2-oxo-2H-benzimidazol-1,3-diyl)-3,1-propanediyldi-1,4-piperidinediyl]bis[5-chloro-1,3-dihydro-2Hbenzimidazol-2-one]
1,1'-[(1,3-dihydro-2-oxo-2H-benzimidazol-1,3-diyl)-3,1-propanediyldi-1,4-piperidinediyl]bis[5-chloro-1,3-dihydro-2Hbenzimidazol-2-one]
Catalogue No.:PA 04 38570
CAS :
NA
Molecular Formula : C34H36Cl2N8O3
Molecular Weight : 675.61
tert-Butyl 3-(3-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate
tert-Butyl 3-(3-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate
Catalogue No.:PAI 04 009030
CAS :
1353347-24-6
Molecular Formula : C27H32ClN5O4
Molecular Weight : 526.03
tert-butyl 3-(3-(4-(3-(3-(3-(tert-Butoxycarbonyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)-5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate
tert-butyl 3-(3-(4-(3-(3-(3-(tert-Butoxycarbonyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)-5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate
Catalogue No.:PAI 04 009040
CAS :
NA
Molecular Formula : C42H50ClN7O7
Molecular Weight : 800.34
1-(3-Chloropropyl)-3-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
1-(3-Chloropropyl)-3-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
Catalogue No.:PA 04 0381003
CAS :
NA
Molecular Formula : C20H21ClN4O2
Molecular Weight : 384.86
tert-Butyl 6-chloro-2-oxo-3-(1-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate
tert-butyl 6-chloro-2-oxo-3-(1-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate
Catalogue No.:PAI 04 009054
CAS :
1353347-23-5
Molecular Formula : C27H32ClN5O4
Molecular Weight : 526.03
Domperidone
tert-Butyl 6-chloro-2-oxo-3-(1-(3-(2-oxo-3-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate
Catalogue No.:PAI 04 009055
CAS :
NA
Molecular Formula : C37H42ClN7O5
Molecular Weight : 700.24
6-Chloro-2-oxo-3-(1-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-2,3-dihydro-1H-benzo[d]imidazole-1-carbaldehyde
6-Chloro-2-oxo-3-(1-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-2,3-dihydro-1H-benzo[d]imidazole-1-carbaldehyde
Catalogue No.:PA 04 0381006
CAS :
NA
Molecular Formula : C23H24ClN5O3
Molecular Weight : 453.93
1-(3-(4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-3-nitroso-1,3-dihydro-2H-benzo[d]imidazol-2-one
1-(3-(4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-3-nitroso-1,3-dihydro-2H-benzo[d]imidazol-2-one
Catalogue No.:PA 04 0381009
CAS :
NA
Molecular Formula : C22H23ClN6O3
Molecular Weight : 454.92
5-Chloro-3-nitroso-1-(1-(3-(3-nitroso-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
5-Chloro-3-nitroso-1-(1-(3-(3-nitroso-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
Catalogue No.:PA 04 0381010
CAS :
NA
Molecular Formula : C22H22ClN7O4
Molecular Weight : 483.91
1-(3-(4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-3-(3-(2-oxo-3-(prop-1-en-2-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
1-(3-(4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-3-(3-(2-oxo-3-(prop-1-en-2-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
Catalogue No.:PAI 04 009057
CAS :
NA
Molecular Formula : C35H38ClN7O3
Molecular Weight : 640.19
5-Chloro-3-(3-(2-oxo-3-(prop-1-en-2-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)-1-(1-(3-(2-oxo-3-(prop-1-en-2-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
5-Chloro-3-(3-(2-oxo-3-(prop-1-en-2-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)-1-(1-(3-(2-oxo-3-(prop-1-en-2-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
Catalogue No.:PAI 04 009058
CAS :
NA
Molecular Formula : C38H42ClN7O3
Molecular Weight : 680.25
5-Chloro-3-(3-(2-ethoxy-1H-benzo[d]imidazol-1-yl)propyl)-1-(1-(3-(2-ethoxy-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
5-Chloro-3-(3-(2-ethoxy-1H-benzo[d]imidazol-1-yl)propyl)-1-(1-(3-(2-ethoxy-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
Catalogue No.:PAI 04 009060
CAS :
NA
Molecular Formula : C36H42ClN7O3
Molecular Weight : 656.23
1-(3-(4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-4-hydroxy-1,3-dihydro-2H-benzo[d]imidazol-2-one
1-(3-(4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-4-hydroxy-1,3-dihydro-2H-benzo[d]imidazol-2-one
Catalogue No.:PA 04 0381011
CAS :
1214264-64-8
Molecular Formula : C22H24ClN5O3
Molecular Weight : 441.92
1-(3-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
1-(3-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
Catalogue No.:PA 04 0381016
CAS :
62781-23-1
Molecular Formula : C22H25N5O2
Molecular Weight : 391.48
