Doripenem and its Impurities
Doripenem is an antibiotic drug. It is used to treat serious infections of the urinary tract, kidney, and abdomen that are caused by bacteria. Reference standards of Doripenem API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(4R,5S,6S)-3-(((3S,5S)-5-(Aminomethyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid
(4R,5S,6S)-3-(((3S,5S)-5-(Aminomethyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid
Catalogue No.:PA 31 80510
CAS :
175845-95-1
Molecular Formula : C15H23N3O4S
Molecular Weight : 341.43


(4R,5R,E)-6-Ethylidene-4-methyl-7-oxo-3-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid
(4R,5R,E)-6-Ethylidene-4-methyl-7-oxo-3-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid
Catalogue No.:PA 31 80520
CAS :
NA
Molecular Formula : C15H22N4O5S2
Molecular Weight : 402.48


(2R,5S)-5-((1S,2R)-1-Carboxy-2-hydroxypropyl)-4-methyl-3-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-2,5-dihydro-1H-pyrrole-2-carboxylic Acid
(2R,5S)-5-((1S,2R)-1-Carboxy-2-hydroxypropyl)-4-methyl-3-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-2,5-dihydro-1H-pyrrole-2-carboxylic Acid
Catalogue No.:PA 31 80530
CAS :
NA
Molecular Formula : C15H26N4O7S2
Molecular Weight : 438.51


(2S,2'S,3R,3'R)-2,2'-((2R,3S,7R,8S)-2,7-Dimethyl-5,10-dioxo-1-(((3R,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-6-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-2,7,8,10-tetrahydro-3H,5H-dipyrrolo[1,2-a:1',2'-d]pyrazine-3,8-diyl)bis(3-hydroxybutanoic Acid)
(2S,2'S,3R,3'R)-2,2'-((2R,3S,7R,8S)-2,7-Dimethyl-5,10-dioxo-1-(((3R,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-6-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-2,7,8,10-tetrahydro-3H,5H-dipyrrolo[1,2-a:1',2'-d]pyrazine-3,8-diyl)bis(3-hydroxybutanoic Acid)
Catalogue No.:PA 31 80540
CAS :
NA
Molecular Formula : C30H48N8O12S4
Molecular Weight : 841


(2S,4R)-4-(Acetylthio)-2-[[(aminosulfonyl)[(1,1-dimethylethoxy)carbonyl]amino]methyl]-1-pyrrolidinecarboxylic Acid (4-Nitrophenyl) Ethyl Ester
(2S,4R)-4-(Acetylthio)-2-[[(aminosulfonyl)[(1,1-dimethylethoxy)carbonyl]amino]methyl]-1-pyrrolidinecarboxylic Acid (4-Nitrophenyl) Ethyl Ester
Catalogue No.:PA 31 80550
CAS :
571176-82-4
Molecular Formula : C20H28N4O9S2
Molecular Weight : 532.58


(4R,5S,6S)-3-(((3S,5S)-1-((2S,3R)-2-((2S,3R)-5-Carboxy-3-methyl-4-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-2,3-dihydro-1H-pyrrol-2-yl)-3-hydroxybutanoyl)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid
(4R,5S,6S)-3-(((3S,5S)-1-((2S,3R)-2-((2S,3R)-5-Carboxy-3-methyl-4-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-2,3-dihydro-1H-pyrrol-2-yl)-3-hydroxybutanoyl)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid
Catalogue No.:PA 31 80570
CAS :
NA
Molecular Formula : C30H48N8O12S4
Molecular Weight : 841


(4R,5S,6S)-3-(((3S,5S)-1-((3R)-2-((2S,3R)-5-Carboxy-3-hydroxy-4-(((3R,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-3,4-dihydro-2H-pyrrol-2-yl)-3-hydroxybutanoyl)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid
(4R,5S,6S)-3-(((3S,5S)-1-((3R)-2-((2S,3R)-5-Carboxy-3-hydroxy-4-(((3R,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-3,4-dihydro-2H-pyrrol-2-yl)-3-hydroxybutanoyl)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid
Catalogue No.:PA 31 80580
CAS :
NA
Molecular Formula : C29H46N8O13S4
Molecular Weight : 842.97


(2S,3R,4S)-2-((1S,2R)-1-Carboxy-2-hydroxypropyl)-3-methyl-4-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-3,4-dihydro-2H-pyrrole-5-carboxylic Acid
(2S,3R,4S)-2-((1S,2R)-1-Carboxy-2-hydroxypropyl)-3-methyl-4-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-3,4-dihydro-2H-pyrrole-5-carboxylic Acid
Catalogue No.:PA 31 80590
CAS :
NA
Molecular Formula : C15H26N4O7S2
Molecular Weight : 438.51


(4R,5S,6S)-3-(((3S,5S)-5-(((N-(tert-Butyl)sulfamoyl)amino)methyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid
(4R,5S,6S)-3-(((3S,5S)-5-(((N-(tert-Butyl)sulfamoyl)amino)methyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid
Catalogue No.:PA 31 80600
CAS :
1973411-88-9
Molecular Formula : C19H32N4O6S2
Molecular Weight : 476.61


(4R,5S,6S)-3-(((3S,5S)-5-(((N-((E)-(Dimethylamino)methylene)sulfamoyl)amino)methyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid
(4R,5S,6S)-3-(((3S,5S)-5-(((N-((E)-(Dimethylamino)methylene)sulfamoyl)amino)methyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid
Catalogue No.:PA 31 80610
CAS :
NA
Molecular Formula : C18H29N5O6S2
Molecular Weight : 475.58


(1R,4S,5S,6R)-4-((R)-1-Hydroxyethyl)-8-((4R,5S,6S)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-3-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-1-azabicyclo[3.2.0]hept-2-ene-2-carbonyl)-6-methyl-3-oxo-7-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-2-oxa-8-azabicyclo[3.2.1]octane-1-carboxylic Acid
(1R,4S,5S,6R)-4-((R)-1-Hydroxyethyl)-8-((4R,5S,6S)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-3-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-1-azabicyclo[3.2.0]hept-2-ene-2-carbonyl)-6-methyl-3-oxo-7-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-2-oxa-8-azabicyclo[3.2.1]octane-1-carboxylic Acid
Catalogue No.:PA 31 80620
CAS :
NA
Molecular Formula : C30H48N8O12S4
Molecular Weight : 841


(4R,5S,6S)-6-((R)-1-Hydroxyethyl)-4-methyl-7-oxo-3-((S)-((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)sulfinyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid
(4R,5S,6S)-6-((R)-1-Hydroxyethyl)-4-methyl-7-oxo-3-((S)-((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)sulfinyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid
Catalogue No.:PA 31 80630
CAS :
NA
Molecular Formula : C15H24N4O7S2
Molecular Weight : 436.5


(4S,5S,6R)-4-((R)-1-Hydroxyethyl)-8-((4R,5S,6S)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-3-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-1-azabicyclo[3.2.0]hept-2-ene-2-carbonyl)-6-methyl-3-oxo-7-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-2-oxa-8-azabicyclo[3.2.1]octane-1-carboxylic Acid
(4S,5S,6R)-4-((R)-1-Hydroxyethyl)-8-((4R,5S,6S)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-3-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-1-azabicyclo[3.2.0]hept-2-ene-2-carbonyl)-6-methyl-3-oxo-7-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-2-oxa-8-azabicyclo[3.2.1]octane-1-carboxylic Acid
Catalogue No.:PA 31 0801000
CAS :
NA
Molecular Formula : C30H48N8O12S4
Molecular Weight : 841


(2S,3R)-2-((1S,2R)-1-Carboxy-2-hydroxypropyl)-3-methyl-4-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-3,4-dihydro-2H-pyrrole-5-carboxylic Acid
(2S,3R)-2-((1S,2R)-1-Carboxy-2-hydroxypropyl)-3-methyl-4-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-3,4-dihydro-2H-pyrrole-5-carboxylic Acid
Catalogue No.:PA 31 0801001
CAS :
2220995-13-9
Molecular Formula : C15H26N4O7S2
Molecular Weight : 438.51