Duocarmycin and its Impurities
Duocarmycins are members of a series of related natural products. An antibody-drug conjugate targeting GPR56 demonstrates efficacy in preclinical models of colorectal cancer. Reference standards of Duocarmycin API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
tert-butyl (S)-(4-((2-(1-(Chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)-1H-indol-5-yl)carbamoyl)phenyl)carbamate
tert-butyl (S)-(4-((2-(1-(Chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)-1H-indol-5-yl)carbamoyl)phenyl)carbamate
Catalogue No.:PA 04 3131002
CAS :
372954-15-9
Molecular Formula : C34H31ClN4O5
Molecular Weight : 611.1
