edaravone and its Impurities
Edaravone is used to help people recover from stroke in Japan, and is used to treat ALS in the US and Japan. It is sold as under the brand names Radicava. Reference standards of Edaravone API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below


2,4-Dihydro-4,4-bis(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-5-methyl-2-phenyl-3H-pyrazol-3-one;
2,4-Dihydro-4,4-bis(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-5-methyl-2-phenyl-3H-pyrazol-3-one;
Catalogue No.:PA 32 06580
CAS :
124009-63-8
Molecular Formula : C30H26N6O3
Molecular Weight : 518.58


5,5"-dihydroxy-3,3",5'-trimethyl-1,1",2'-triphenyl-4,4",5,5"-tetrahydro-1H,1"H-[4,4':4',4"-terpyrazol]-3'(2'H)-one
5,5"-dihydroxy-3,3",5'-trimethyl-1,1",2'-triphenyl-4,4",5,5"-tetrahydro-1H,1"H-[4,4':4',4"-terpyrazol]-3'(2'H)-one
Catalogue No.:PA 32 0061000
CAS :
NA
Molecular Formula : C30H30N6O3
Molecular Weight : 522.61


5-Hydroxy-3,5',5"-trimethyl-1,2',2"-triphenyl-2",4,4",5-tetrahydro-1H,3"H-[4,4':4',4"-terpyrazole]-3',3"(2'H)-dione
5-Hydroxy-3,5',5"-trimethyl-1,2',2"-triphenyl-2",4,4",5-tetrahydro-1H,3"H-[4,4':4',4"-terpyrazole]-3',3"(2'H)-dione
Catalogue No.:PA 32 0061005
CAS :
NA
Molecular Formula : C30H28N6O3
Molecular Weight : 520.59


5'-(Hydroxymethyl)-4,5-dimethyl-2,2'-diphenyl-2,2',4,4'-tetrahydro-3H,3'H-[4,4'-bipyrazole]-3,3'-dione
5'-(Hydroxymethyl)-4,5-dimethyl-2,2'-diphenyl-2,2',4,4'-tetrahydro-3H,3'H-[4,4'-bipyrazole]-3,3'-dione
Catalogue No.:PA 32 0061008
CAS :
NA
Molecular Formula : C21H20N4O3
Molecular Weight : 376.42


3'-(Hydroxymethyl)-3"-methyl-5,5',5"-trioxo-1,1',1"-triphenyl-1',4,4",5,5',5"-hexahydro-1H,1"H-[4,4':4',4"-terpyrazole]-3-carboxylic Acid
3'-(Hydroxymethyl)-3"-methyl-5,5',5"-trioxo-1,1',1"-triphenyl-1',4,4",5,5',5"-hexahydro-1H,1"H-[4,4':4',4"-terpyrazole]-3-carboxylic Acid
Catalogue No.:PA 32 0061009
CAS :
NA
Molecular Formula : C30H24N6O6
Molecular Weight : 564.56


5-(Hydroxymethyl)-5',5"-dimethyl-2,2',2"-triphenyl-2,2",4,4"-tetrahydro-3H,3"H-[4,4':4',4"-terpyrazole]-3,3',3"(2'H)-trione
5-(Hydroxymethyl)-5',5"-dimethyl-2,2',2"-triphenyl-2,2",4,4"-tetrahydro-3H,3"H-[4,4':4',4"-terpyrazole]-3,3',3"(2'H)-trione
Catalogue No.:PA 32 0061010
CAS :
NA
Molecular Formula : C30H26N6O4
Molecular Weight : 534.58


1-Hydroxy-2-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)propane-2-sulfonic acid, Sodium Salt
1-Hydroxy-2-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)propane-2-sulfonic acid, Sodium Salt
Catalogue No.:PA 32 0061018
CAS :
1322767-62-3
Molecular Formula : C13H16N2NaO5S
Molecular Weight : 335.33


4-Hydroxy-5,5'-dimethyl-2,2'-diphenyl-2,2',4,4'-tetrahydro-3H,3'H-[4,4'-bipyrazole]-3,3'-dione
4-Hydroxy-5,5'-dimethyl-2,2'-diphenyl-2,2',4,4'-tetrahydro-3H,3'H-[4,4'-bipyrazole]-3,3'-dione
Catalogue No.:PA 32 0061026
CAS :
153952-07-9
Molecular Formula : C20H18N4O3
Molecular Weight : 362.39