efavirenz and its Impurities
Efavirenz is a non-nucleoside reverse transcriptase inhibitor and is used as part of highly active antiretroviral therapy for the treatment of a human immunodeficiency virus type 1.. Reference standards of Efavirenz API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below


(R)-6-Chloro-4-(3-methylbut-3-en-1-yn-1-yl)-4-(trifluoromethyl)-1H-benzo[d][1,3]oxazin-2(4H)-one
(R)-6-Chloro-4-(3-methylbut-3-en-1-yn-1-yl)-4-(trifluoromethyl)-1H-benzo[d][1,3]oxazin-2(4H)-one
Catalogue No.:PA 05 53650
CAS :
NA
Molecular Formula : C14H9ClF3NO2
Molecular Weight : 315.67


6-Chloro-4-(cyclopropylethynyl)-1-(4-methoxybenzyl)-4-(trifluoromethyl)-1H-benzo[d][1,3]oxazin-2(4H)-one
6-Chloro-4-(cyclopropylethynyl)-1-(4-methoxybenzyl)-4-(trifluoromethyl)-1H-benzo[d][1,3]oxazin-2(4H)-one
Catalogue No.:PA 05 53670
CAS :
2990807-70-8
Molecular Formula : C22H17ClF3NO3
Molecular Weight : 435.82


(R)-N-(4-Chloro-2-(4-cyclopropyl-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl)phenyl)-4-methoxybenzamide
(R)-N-(4-Chloro-2-(4-cyclopropyl-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl)phenyl)-4-methoxybenzamide
Catalogue No.:PA 05 53680
CAS :
NA
Molecular Formula : C21H17ClF3NO3
Molecular Weight : 423.82


(S)-N-(4-Chloro-2-(4-cyclopropyl-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl)phenyl)-4-methoxybenzamide
(S)-N-(4-Chloro-2-(4-cyclopropyl-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl)phenyl)-4-methoxybenzamide
Catalogue No.:PA 05 53690
CAS :
353270-77-6
Molecular Formula : C21H17ClF3NO3
Molecular Weight : 423.81


(4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-1-[(4-methoxyphenyl)methyl]-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
(4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-1-[(4-methoxyphenyl)methyl]-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
Catalogue No.:PA 05 53710
CAS :
174819-21-7
Molecular Formula : C22H17ClF3NO3
Molecular Weight : 435.82


Efavirenz Racemic ((+/-)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-ben (1234114)
Efavirenz Racemic ((+/-)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-ben (1234114)
Catalogue No.:PA USP1234114
CAS :
177530-93-7
Molecular Formula : NA
Molecular Weight : NA


Efavirenz Related Compound A ((S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn- (1234125)
Efavirenz Related Compound A ((S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn- (1234125)
Catalogue No.:PA USP1234125
CAS :
209414-27-7
Molecular Formula : NA
Molecular Weight : NA


Efavirenz Related Compound B ((S,E)-6-Chloro-4-(2-Cyclopropylvinyl)-4-(trifluoromethyl)-2H-3,1-benz (1234147)
Efavirenz Related Compound B ((S,E)-6-Chloro-4-(2-Cyclopropylvinyl)-4-(trifluoromethyl)-2H-3,1-benz (1234147)
Catalogue No.:PA USP1234147
CAS :
440124-96-9
Molecular Formula : NA
Molecular Weight : NA


(Z)-6-Chloro-4-(pent-3-en-1-yn-1-yl)-4-(trifluoromethyl)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
(Z)-6-Chloro-4-(pent-3-en-1-yn-1-yl)-4-(trifluoromethyl)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
Catalogue No.:PA 05 53740
CAS :
NA
Molecular Formula : C14H9ClF3NO2
Molecular Weight : 315.68


(E)-6-Chloro-4-(pent-3-en-1-yn-1-yl)-4-(trifluoromethyl)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
(E)-6-Chloro-4-(pent-3-en-1-yn-1-yl)-4-(trifluoromethyl)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
Catalogue No.:PA 05 53750
CAS :
NA
Molecular Formula : C14H9ClF3NO2
Molecular Weight : 315.68


6-Chloro-4-(3-methylbut-3-en-1-yn-1-yl)-4-(trifluoromethyl)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
6-Chloro-4-(3-methylbut-3-en-1-yn-1-yl)-4-(trifluoromethyl)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
Catalogue No.:PA 05 53760
CAS :
NA
Molecular Formula : C14H9ClF3NO2
Molecular Weight : 315.68


rac N-[4-Chloro-2-[3-cyclopropyl-1-hydroxy-1-(trifluoromethyl)-2-propynyl]phenyl]-4-methoxybenzamide
rac N-[4-Chloro-2-[3-cyclopropyl-1-hydroxy-1-(trifluoromethyl)-2-propynyl]phenyl]-4-methoxybenzamide
Catalogue No.:PA 05 0531001
CAS :
1189491-03-9
Molecular Formula : C21H17ClF3NO3
Molecular Weight : 423.82


(4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-2-(4-methoxyphenyl)-4-(trifluoromethyl)-2H-3,1-benzoxazine (Mixture of 2 Diastereomers)
(4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-2-(4-methoxyphenyl)-4-(trifluoromethyl)-2H-3,1-benzoxazine (Mixture of 2 Diastereomers)
Catalogue No.:PA 05 0531005
CAS :
209414-26-6
Molecular Formula : C21H17ClF3NO2
Molecular Weight : 407.82


rac 5-Chloro-a-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino] -a-(trifluoromethyl)benzenemethanol
Rac 5-Chloro-a-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino] -a-(trifluoromethyl)benzenemethanol
Catalogue No.:PA 05 0531006
CAS :
221177-56-6
Molecular Formula : C21H19ClF3NO2
Molecular Weight : 409.83


6-chloro-4-(5-chloropent-1-yn-1-yl)-4-(trifluoromethyl)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
6-chloro-4-(5-chloropent-1-yn-1-yl)-4-(trifluoromethyl)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
Catalogue No.:PA 05 0531012
CAS :
202721-02-6
Molecular Formula : C14H10Cl2F3NO2
Molecular Weight : 352.13


(S)-5-Chloro-a-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino]-a-(trifluoromethyl)benzenemethanol
(S)-5-Chloro-a-(cyclopropylethynyl)-2-[[(4-methoxyphenyl)methyl]amino]-a-(trifluoromethyl)benzenemethanol
Catalogue No.:PA 05 0531013
CAS :
173676-60-3
Molecular Formula : C21H19ClF3NO2
Molecular Weight : 409.83