Elacestrant and its Impurities
Elacestrant, sold under the brand name Orserdu, is an anticancer medication. it is an estrogen receptor antagonist used to treat ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer with disease progression following at least one line of endocrine therapy. Reference standards of Elacestrant API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(R)-N-Ethyl-N-(4-((ethyl(2-(6-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-5-methoxyphenyl)amino)methyl)phenethyl)nitrous amide
(R)-N-Ethyl-N-(4-((ethyl(2-(6-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-5-methoxyphenyl)amino)methyl)phenethyl)nitrous amide
Catalogue No.:PA 05 2151002
CAS :
NA
Molecular Formula : C30H37N3O3
Molecular Weight : 487.64


(S)-N-Ethyl-N-(4-((ethyl(2-(6-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-5-methoxyphenyl)amino)methyl)phenethyl)nitrous amide
(S)-N-Ethyl-N-(4-((ethyl(2-(6-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-5-methoxyphenyl)amino)methyl)phenethyl)nitrous amide
Catalogue No.:PA 05 2151003
CAS :
NA
Molecular Formula : C30H37N3O3
Molecular Weight : 487.64


(R)-N-(4-(2-(Ethylamino)ethyl)benzyl)-N-(2-(6-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-5-methoxyphenyl)nitrous amide
(R)-N-(4-(2-(Ethylamino)ethyl)benzyl)-N-(2-(6-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-5-methoxyphenyl)nitrous amide
Catalogue No.:PA 05 2151004
CAS :
NA
Molecular Formula : C28H33N3O3
Molecular Weight : 459.59


(R)-6-(2-((4-(2-(Ethylamino)ethyl)benzyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol
(R)-6-(2-((4-(2-(Ethylamino)ethyl)benzyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol
Catalogue No.:PA 05 2151005
CAS :
NA
Molecular Formula : C28H34N2O2
Molecular Weight : 430.59


(R)-6-(2-((4-(2-(Ethylamino)-2-oxoethyl)benzyl)(nitroso)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl methanesulfonate
(R)-6-(2-((4-(2-(Ethylamino)-2-oxoethyl)benzyl)(nitroso)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl methanesulfonate
Catalogue No.:PA 05 2151007
CAS :
NA
Molecular Formula : C29H33N3O6S
Molecular Weight : 551.66


(R)-6-(2-((4-(2-(Ethyl(nitroso)amino)ethyl)benzyl)(nitroso)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl methanesulfonate
(R)-6-(2-((4-(2-(Ethyl(nitroso)amino)ethyl)benzyl)(nitroso)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl methanesulfonate
Catalogue No.:PA 05 2151008
CAS :
NA
Molecular Formula : C29H34N4O6S
Molecular Weight : 566.67


Methyl 2-(4-(((2-(6-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-5-methoxyphenyl)(nitroso)amino)methyl)phenyl)acetate
Methyl 2-(4-(((2-(6-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-5-methoxyphenyl)(nitroso)amino)methyl)phenyl)acetate
Catalogue No.:PA 05 2151012
CAS :
NA
Molecular Formula : C27H28N2O5
Molecular Weight : 460.53


2-(4-(((2-(6-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-5-methoxyphenyl)(nitroso)amino)methyl)phenyl)acetic Acid
2-(4-(((2-(6-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-5-methoxyphenyl)(nitroso)amino)methyl)phenyl)acetic Acid
Catalogue No.:PA 05 2151013
CAS :
NA
Molecular Formula : C26H26N2O5
Molecular Weight : 446.5


6-(2-(Ethyl(nitroso)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl methanesulfonate
6-(2-(Ethyl(nitroso)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl methanesulfonate
Catalogue No.:PA 05 2151014
CAS :
NA
Molecular Formula : C20H24N2O5S
Molecular Weight : 404.48


Methyl 2-(4-(((5-methoxy-2-(6-((methylsulfonyl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl)(nitroso)amino)methyl)phenyl)acetate
Methyl 2-(4-(((5-methoxy-2-(6-((methylsulfonyl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl)(nitroso)amino)methyl)phenyl)acetate
Catalogue No.:PA 05 2151015
CAS :
NA
Molecular Formula : C28H30N2O7S
Molecular Weight : 538.62


2-(4-(((5-Methoxy-2-(6-((methylsulfonyl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl)(nitroso)amino)methyl)phenyl)acetic Acid
2-(4-(((5-Methoxy-2-(6-((methylsulfonyl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl)(nitroso)amino)methyl)phenyl)acetic Acid
Catalogue No.:PA 05 2151016
CAS :
NA
Molecular Formula : C27H28N2O7S
Molecular Weight : 524.59